This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

By meta‐analysis and systematic review of randomized controlled trials (RCTs), to evaluate the role of prokinetics in the treatment of functional dyspepsia (FD) as reflected by improvement of either individual or global dyspepsia symptom scores and quality of life scores. The primary comparisons will be as follows.

• Are prokinetic drugs in general better than placebo?

• Which of the individual prokinetic drugs is the most effective?