1 Step frequency (8 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

4.91 [‐1.78, 11.61]

1.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

4.91 [‐1.78, 11.61]

2 Step frequency (9 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐10.23 [‐16.53, ‐3.93]

2.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐10.23 [‐16.53, ‐3.93]

3 Step frequency (10 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

7.72 [2.57, 12.86]

3.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

7.72 [2.57, 12.86]

4 Step frequency (11 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐1.63 [‐6.69, 3.42]

4.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐1.63 [‐6.69, 3.42]

5 Step frequency (12 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐9.20 [‐14.54, ‐3.86]

5.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐9.20 [‐14.54, ‐3.86]

6 Step frequency (13 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

7.53 [2.24, 12.82]

6.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

7.53 [2.24, 12.82]

7 Step frequency (14 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐6.60 [‐12.51, ‐0.69]

7.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐6.60 [‐12.51, ‐0.69]

8 Step frequency (15 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

7.90 [1.58, 14.22]

8.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

7.90 [1.58, 14.22]

9 Step frequency (16 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

4.36 [‐2.63, 11.35]

9.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

4.36 [‐2.63, 11.35]

10 Step quality (8 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

8.44 [0.46, 16.42]

10.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

8.44 [0.46, 16.42]

11 Step quality (9 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

2.69 [‐4.79, 10.17]

11.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

2.69 [‐4.79, 10.17]

12 Step quality (10 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐15.67 [‐21.69, ‐9.66]

12.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐15.67 [‐21.69, ‐9.66]

13 Step quality (11 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐20.98 [‐26.87, ‐15.08]

13.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐20.98 [‐26.87, ‐15.08]

14 Step quality (12 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐14.30 [‐20.57, ‐8.04]

14.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐14.30 [‐20.57, ‐8.04]

15 Step quality (13 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐34.67 [‐40.87, ‐28.47]

15.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐34.67 [‐40.87, ‐28.47]

16 Step quality (14 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐33.34 [‐40.33, ‐26.36]

16.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐33.34 [‐40.33, ‐26.36]

17 Step quality (15 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐24.92 [‐32.43, ‐17.42]

17.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐24.92 [‐32.43, ‐17.42]

18 Step quality (16 months) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐15.61 [‐23.96, ‐7.27]

18.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐15.61 [‐23.96, ‐7.27]

19 Age of onset of independent walking Show forest plot

2

58

Mean Difference (IV, Fixed, 95% CI)

‐1.47 [‐2.97, 0.03]

19.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐0.60 [‐2.34, 1.14]

19.2 Down syndrome

1

30

Mean Difference (IV, Fixed, 95% CI)

‐4.0 [‐6.96, ‐1.04]

20 Onset of walking with assistance [days in study] Show forest plot

1

30

Mean Difference (IV, Fixed, 95% CI)

‐74.0 [‐135.40, ‐12.60]

20.1 Down syndrome

1

30

Mean Difference (IV, Fixed, 95% CI)

‐74.0 [‐135.40, ‐12.60]

21 Gross motor function: GMFM Show forest plot

2

36

Mean Difference (IV, Fixed, 95% CI)

0.88 [‐4.54, 6.30]

21.1 Spastic cerebral palsy

1

8

Mean Difference (IV, Fixed, 95% CI)

7.60 [‐19.46, 34.66]

21.2 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

0.60 [‐4.93, 6.13]

22 Other gait parameters: velocity Show forest plot

1

8

Mean Difference (IV, Fixed, 95% CI)

0.39 [‐4.19, 4.97]

22.1 Spastic cerebral palsy

1

8

Mean Difference (IV, Fixed, 95% CI)

0.39 [‐4.19, 4.97]

23 Other gait parameters: velocity (follow‐up when walking independently) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

1.32 [‐0.53, 3.17]

23.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

1.32 [‐0.53, 3.17]

24 Other gait parameters: velocity (follow‐up 3 months later) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐1.92 [‐4.72, 0.88]

24.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐1.92 [‐4.72, 0.88]

25 Other gait parameters: velocity (follow‐up 6 months later) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐3.35 [‐7.44, 0.74]

25.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐3.35 [‐7.44, 0.74]

26 Other gait parameters: step length Show forest plot

1

8

Mean Difference (IV, Fixed, 95% CI)

0.37 [‐25.04, 25.78]

26.1 Spastic cerebral palsy

1

8

Mean Difference (IV, Fixed, 95% CI)

0.37 [‐25.04, 25.78]

27 Other gait parameters: step length (follow‐up when walking independently) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

8.0 [‐1.60, 17.60]

27.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

8.0 [‐1.60, 17.60]

28 Other gait parameters: step length (follow‐up 3 months later) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐5.0 [‐14.26, 4.26]

28.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐5.0 [‐14.26, 4.26]

29 Other gait parameters: step length (follow‐up 6 months later) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐6.0 [‐15.26, 3.26]

29.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐6.0 [‐15.26, 3.26]

30 Other gait parameters: gait double‐limb support Show forest plot

1

8

Mean Difference (IV, Fixed, 95% CI)

3.80 [‐21.52, 29.12]

30.1 Spastic cerebral palsy

1

8

Mean Difference (IV, Fixed, 95% CI)

3.80 [‐21.52, 29.12]

31 Other gait parameters: gait double‐limb support (follow‐up when walking independently) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

‐4.19 [‐10.02, 1.64]

31.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

‐4.19 [‐10.02, 1.64]

32 Other gait parameters: gait double‐limb support (follow‐up 3 months later) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

3.16 [‐0.22, 6.54]

32.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

3.16 [‐0.22, 6.54]

33 Other gait parameters: gait double‐limb support (follow‐up 6 months later) Show forest plot

1

28

Mean Difference (IV, Fixed, 95% CI)

3.17 [‐0.10, 6.44]

33.1 Risk of developmental delay

1

28

Mean Difference (IV, Fixed, 95% CI)

3.17 [‐0.10, 6.44]

1 Walking independently (1 month follow‐up) Show forest plot

1

17

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐5.96, 6.16]

1.1 Down syndrome

1

17

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐5.96, 6.16]

2 Gross motor function (GMFM 1 month follow‐up) Show forest plot

1

17

Mean Difference (IV, Fixed, 95% CI)

‐8.40 [‐14.55, ‐2.25]

2.1 Down syndrome

1

17

Mean Difference (IV, Fixed, 95% CI)

‐8.40 [‐14.55, ‐2.25]

1 Step frequency Show forest plot

1

30

Mean Difference (IV, Fixed, 95% CI)

‐11.0 [‐15.90, ‐6.10]

1.1 Down syndrome

1

30

Mean Difference (IV, Fixed, 95% CI)

‐11.0 [‐15.90, ‐6.10]

2 Age of onset of independent walking Show forest plot

1

30

Mean Difference (IV, Fixed, 95% CI)

‐2.13 [‐4.96, 0.70]

2.1 Down syndrome

1

30

Mean Difference (IV, Fixed, 95% CI)

‐2.13 [‐4.96, 0.70]

3 Onset of walking with assistance Show forest plot

1

30

Mean Difference (IV, Fixed, 95% CI)

‐1.86 [‐4.09, 0.37]

3.1 Down syndrome

1

30

Mean Difference (IV, Fixed, 95% CI)

‐1.86 [‐4.09, 0.37]

4 Chronological Age. Follow‐up (visit 1) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.60 [‐6.77, ‐0.43]

4.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.60 [‐6.77, ‐0.43]

5 Chronological Age. Follow‐up (visit 2) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐4.0 [‐6.86, ‐1.14]

5.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐4.0 [‐6.86, ‐1.14]

6 Chronological Age. Follow‐up (visit 3) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.20 [‐6.34, ‐0.06]

6.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.20 [‐6.34, ‐0.06]

7 Chronological Age. Follow‐up (visit 4) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.80 [‐5.89, 0.29]

7.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.80 [‐5.89, 0.29]

8 Other gait parameters: velocity follow‐up (visit1) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

0.05 [‐0.06, 0.16]

8.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

0.05 [‐0.06, 0.16]

9 Other gait parameters: velocity follow‐up (visit 2) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

0.16 [0.01, 0.31]

9.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

0.16 [0.01, 0.31]

10 Other gait parameters: velocity follow‐up (visit 3) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐0.07, 0.27]

10.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐0.07, 0.27]

11 Other gait parameters: velocity follow‐up (visit 4) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

0.16 [‐0.07, 0.39]

11.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

0.16 [‐0.07, 0.39]

12 Other gait parameters: step length follow‐up (visit 1) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

1.83 [‐0.89, 4.55]

12.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

1.83 [‐0.89, 4.55]

13 Other gait parameters: step length follow‐up (visit 2) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

2.55 [‐0.67, 5.77]

13.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

2.55 [‐0.67, 5.77]

14 Other gait parameters: step length follow‐up (visit 3) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

0.68 [‐1.96, 3.32]

14.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

0.68 [‐1.96, 3.32]

15 Other gait parameters: step length follow‐up (visit 4) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

2.68 [‐0.99, 6.35]

15.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

2.68 [‐0.99, 6.35]

16 Other gait parameters: step width follow‐up (visit 1) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

0.12 [‐2.37, 2.61]

16.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

0.12 [‐2.37, 2.61]

17 Other gait parameters: step width follow‐up (visit 2) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐1.23 [‐3.69, 1.23]

17.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐1.23 [‐3.69, 1.23]

18 Other gait parameters: step width follow‐up (visit 3) Show forest plot

1

24

Mean Difference (IV, Fixed, 95% CI)

‐0.54 [‐2.52, 1.44]

18.1 Down syndrome

1

24

Mean Difference (IV, Fixed, 95% CI)

‐0.54 [‐2.52, 1.44]

19 Other gait parameters: step width follow‐up (visit 4) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.58 [‐2.11, 0.95]

19.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.58 [‐2.11, 0.95]

20 Other gait parameters: gait double‐limb support follow‐up (visit 1) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.90 [‐8.07, 2.27]

20.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.90 [‐8.07, 2.27]

21 Other gait parameters: gait double‐limb support follow‐up (visit 2) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐4.0 [‐7.91, ‐0.09]

21.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐4.0 [‐7.91, ‐0.09]

22 Other gait parameters: gait double‐limb support follow‐up (visit 3) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.0 [‐6.29, 2.29]

22.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.0 [‐6.29, 2.29]

23 Other gait parameters: gait double‐limb support follow‐up (visit 4) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.80 [‐3.27, 1.67]

23.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.80 [‐3.27, 1.67]

24 Other gait parameters: gait ankle plantar flexion. Follow‐up (Visit 1) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.10 [‐7.34, 1.14]

24.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.10 [‐7.34, 1.14]

25 Other gait parameters: gait ankle plantar flexion. Follow‐up (Visit 2) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐4.80 [‐8.76, ‐0.84]

25.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐4.80 [‐8.76, ‐0.84]

26 Other gait parameters: gait ankle plantar flexion. Follow‐up (Visit 3) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.90 [‐6.28, 0.48]

26.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.90 [‐6.28, 0.48]

27 Other gait parameters: gait ankle plantar flexion. Follow‐up (Visit 4) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.40 [‐8.98, 2.18]

27.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐3.40 [‐8.98, 2.18]

28 Other gait parameters: gait ankle dorsiflexion. Follow‐up (Visit 1) Show forest plot

1

26

Mean Difference (IV, Fixed, 95% CI)

‐0.40 [‐3.47, 2.67]

28.1 Down syndrome

1

26

Mean Difference (IV, Fixed, 95% CI)

‐0.40 [‐3.47, 2.67]

29 Other gait parameters: gait ankle dorsiflexion. Follow‐up (Visit 2) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐1.5 [‐5.08, 2.08]

29.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐1.5 [‐5.08, 2.08]

30 Other gait parameters: gait ankle dorsiflexion. Follow‐up (Visit 3) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.10 [‐2.69, 2.49]

30.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.10 [‐2.69, 2.49]

31 Other gait parameters:gait ankle dorsiflexion. Follow‐up (Visit 4) Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.80 [‐5.96, 0.36]

31.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.80 [‐5.96, 0.36]

32 Other gait parameters: toe‐off follow‐up visit 1 Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.20 [‐6.17, 1.77]

32.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.20 [‐6.17, 1.77]

33 Other gait parameters: toe‐off; follow‐up visit 2 Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.30 [‐5.50, 0.90]

33.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐2.30 [‐5.50, 0.90]

34 Other gait parameters: toe‐off; follow‐up visit 3 Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐1.20 [‐3.95, 1.55]

34.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐1.20 [‐3.95, 1.55]

35 Other gait parameters: toe‐off follow‐up visit 4 Show forest plot

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.90 [‐5.49, 3.69]

35.1 Down syndrome

1

25

Mean Difference (IV, Fixed, 95% CI)

‐0.90 [‐5.49, 3.69]