Clever 1995

Group A (n = 20): Hydrocolloid (polyurethane matrix) dressing

Group B (n = 20): Foam dressing

Number of ulcers healed:
Group A: 16

Group B: 14
Mean time to healing in days (SD)
Group A: 25.19 (23.52)

Group B: 20.43 (14.74)
Median time to healing in days
Group A: 15.5 (range 4 to 76)

Group B: 16.5 (range 4 to 52)
Wound size at 4 weeks mm2 (SD):
Group A: 32.37 (54.12)

Group B: 33.46 (75.22)

n/r

n/r

(Reasons not reported separately for 2 groups):
Group A: 1

Group B: 5

Mean number of dressing changes between clinical visits (SD):
Group A: 2.23 (2.19)

Group B: 2.37 (2.18)

n/r

Jeffcoate 2009

Group A (n = 103): Fibrous‐hydrocolloid

(hydrofibre) dressing

Group B (n = 108): Iodine‐impregnated dressing
Group C (n = 106): non‐adherent dressing, viscose filament gauze

Number of ulcers healed at 24 weeks:
Group A: 46

Group B: 48
Group C: 41
Mean time to healing in days (SD) (fixed at max of 168 days)
Group A: 125.8 (55.9)

Group B: 127.8 (54.2)
Group C  130.7 (52.4)

Mean Cardiff Wound Impact Schedule score at 24 weeks (SD)

Group A: Physical functioning: 71.4 (19.5).  Social functioning: 70.3 (25.4). Well being: 53.1 (19.9)
Group B: Physical functioning: 67.1 (23.6).  Social functioning: 69.7 (24.1). Well being: 51.0 (22.3) 
Group C: Physical functioning: 68.9 (19.1).  Social functioning: 69.8 (23.5). Well being: 50.2 (21.1) 
Other
Study also reports mean and SD for each of the eight domains of the SF‐36. No significant different between the groups for any domain.

Minor amputations (Below ankle):
Group A: 3
Group B: 1
Group C: 1
Major amputations (Above knee)
Group A: 1
Group B: 0
Group C: 1

Non‐serious adverse events
Group A: 227

Group B: 239
Group C: 244
Serious adverse events
Group A: 28

Group B: 37
Group C: 35

Cost in GBP per patient for dressing management:
Mean (95% CI)

Group A: 191.33 (148.41 to 234.25)
Group B: 183.60 (128.92 to 238.21)
Group C: 141.18 (108.18 to 174.17)
Cost in GBP of professional time in managing foot ulcers: Mean (95% CI)

Group A: 459.87 (354.78 to 564.97)
Group B: 556.90 (422.32 to 691.48)
Group C: 448.86 (348.68 to 549.03
Cost in GBP of generating a healed ulcer using non‐adherent dressing (Group C): 362.

Cost in GBP of generating an additional healed ulcer:

Group A: 836

Group B: 848

At same site
Group A: 3
Group B: 7
Group C: 3

Jude 2007

Group A (n = 67): Fibrous‐hydrocolloid (hydrofibre) dressing with 1.2% ionic silver  
Group B (n = 67): Calcium‐alginate dressing

Number of ulcers healed in 8 weeks
Group A: 21
Group B: 15
Velocity of healing cm2/week (SD):
Group A: 0.29 (0.33) (n = 61)
Group B: 0.26 (0.90) (n = 61)
Velocity of healing as % per week (SD):
Group A: 11.6 (17.7) (n = 61)   
Group B: 10.0 (15.5)  (n = 61)                 
Mean time in days to healing (SD):
Group A: 52.6 (1.8)       
Group B: 57.7 (1.7)                                                                
Reduction in ulcer area in 8 weeks:
Group A: 58.1 (53.1).
Group B: 60.5 (42.7). 
Reduction in ulcer depth (cm) at 8 weeks (SD):
Group A:  0.25 (0.49)   
Group B:  0.13 (0.37)   


                              

n/r

n/r

Group A: 25 participants experienced one or more events. Death = 1; Infection = 14. 8 participants discontinued treatment due to AE.                                            
Group B: 26 participants experienced adverse event. Death = 1; Infection = 8. 13 participants discontinued treatment due to AE.                 

Mean number of dressing changes during study:
Group A: 21.9    
Group B: 20.8   

n/r

Kuo 2012

Group A (n = 12): fibrous‐hydrocolloid (hydrofibre) dressing
Group B (n = 12): cream contained extracts from two botanical raw materials, P. amboinicus and C. asiatica.

Percent change in wound size (from baseline ‐ assumed to 14 days).

Median and (IQR)

Group A: ‐22.64 (‐36.90 to ‐3.20)

Group B: ‐ 27.18(‐38.86 to 36.10)

Reported in paper as not statistically significant from Mann‐Whitney U test. P = 0.673

n/r

n/r

Number of people with one or more adverse events

Group A: 5/12 (41.7%)

Group B: 5/12 (41.7%)

Piaggesi 2001

Group A (n = 10): Fibrous‐hydrocolloid

(hydrofibre) dressing
Group B (n = 10): Saline‐moistened gauze dressing

Number of ulcers healed (during period of study):
Group A: 9
Group B: 10
Healing time in days (mean) (SD)
Group A: 127 (46 days)
Group B: 234 (61 days) 
Median % reduction in lesion volume at 8 weeks follow up (interquartile range):
Group A: 50 (26)           
Group B: 35 (15) 
Median % of granulation tissue at 8 weeks follow up (interquartile range)
Group A: 60 (40)               
Group B: 32.5 (10)                       

    

n/r

Group A: Amputation of a lesser toe = 3; Amputation of 2 lesser toes = 1; Metatarsal resection = 1
Group B: Amputation of a lesser toe = 2; Metatarsal resection = 1

Group A: Maceration of peri‐lesional skin = 1; Infective complications = 1
Group B: Maceration of peri‐lesional skin = 2; Infective complications = 3    

Average number of days between dressings changes (SD)
Group A: 2.1 (0.6)
Group B: 2.4 (0.3)

n/r