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Antibiotics for preventing recurrent sore throat

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Referencias

References to studies excluded from this review

Ir a:

Jensen 1991 {published data only}

Jensen J, Larsen S. Treatment of recurrent tonsillitis with clindamycin. An alternative to tonsillectomy?. Clinical Otolaryngology and Allied Sciences 1991;16:498‐500.

Liltholdt 2003 {published data only}

Lildholdt T, Doessing H, Lyster M, Oetzen KE. The natural history of recurrent acute tonsillitis and a clinical trial of azithromycin for antibiotic prophylaxis. Clinical Otolaryngology and Allied Sciences 2003;28(4):371‐3.

Mora 2003 {published and unpublished data}

Mora R, Salami A, Francesco M, Cordone M, Ottoboni S, Passali G, et al. Efficacy of cefpodoxime in the prophylaxis of recurrent pharyngotonsillitis. International Journal of Pediatric Otorhinolaryngology 2003;67 Suppl 1:S225‐8.

Sirimanna 1990 {published data only (unpublished sought but not used)}

Sirimana KS, Madden GJ, Miles SM. The use of long‐acting penicillin in the prophylaxis of recurrent tonsillitis. Journal of Otolaryngology 1990;100:343‐4.

Additional references

Ir a:

AAO‐HNS 2000

AAO‐HNS. Clinical indicators: tonsillectomy, adenoidectomy, adenotonsillectomy. Clinical Indicators Compendium () 2000 (accessed 1 November 2010).

AAO‐HNS 2011

Baugh RF, Archer SM, Mitchell RB, Rosenfeld RM, Amin R, Burns JJ, et al. Clinical practice guideline: tonsillectomy in children. Otolaryngology ‐ Head and Neck Surgery 2011;144:S1‐30. [DOI: 10.1177/0194599810389949]

Bisno 2002

Bisno AL, Gerber MA, Gwaltney JM, Kaplan EL, Schwartz RH. Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Clinical Infectious Diseases 2002;35(2):113‐25.

Blakley 2009

Blakley BW, Magit AE. The role of tonsillectomy in reducing recurrent pharyngitis: a systematic review. Otolaryngology – Head and Neck Surgery 2009;140:291‐7.

Burton 2014

Burton MJ, Glasziou PP, Chong LY, Venekamp RP. Tonsillectomy or adenotonsillectomy versus non‐surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database of Systematic Reviews 2014, Issue 11. [DOI: 10.1002/14651858.CD001802.pub3]

CONSORT Statement

Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT Statement 2010. http://www.consort‐statement.org.

DESCARTE

Little P. DEcision rule for severe Symptoms and Complications of Acute Red Throat in Everyday practice (DESCARTE). http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=2421 (accessed 18 April 2014).

Egger 1997

Egger M, Smith GD, Schneider M, Minder C. Bias in meta‐analysis detected by a simple, graphical test. BMJ 1997;315:629‐34.

eTG 2014

Pharyngitis and/or tonsillitis. eTG complete http://www.etg.hcn.net.au/ Revised October 2014 (accessed 22 February 2015).

Froom 1990

Froom J, Culpepper L, Grob P, Bartelds A, Bowers P, Bridges‐Webb C, et al. Diagnosis and antibiotic treatment of acute otitis media: report from International Primary Care Network. BMJ 1990;300:582‐6.

Handbook 2011

Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org.

Harbord 2006

Harbord RM, Egger M, Sterne JA. A modified test for small‐study effects in meta‐analyses of controlled trials with binary endpoints. Statistics in Medicine 2006;25:3443‐57.

Howie 1971

Howie JGR, Gill G, Durno D. Respiratory illness and antibiotic use in general practice. Journal of the Royal College of General Practitioners 1971;21:657‐61.

Ilyas 2008

Ilyas M, Tolaymat A. Changing epidemiology of acute post‐streptococcal glomerulonephritis in Northeast Florida: a comparative study. Pediatric Nephrology 2008;23(7):1101‐67.

Lildholdt 2003

Lildholdt, Doessing H, Lyster M, Outzen KE. The natural history of recurrent acute tonsillitis and a clinical trial of azithromycin for antibiotic prophylaxis. Clinical Otolaryngology 2003;28:371‐3.

Matthys 2007

Matthys J, De Meyere M, van Driel ML, De Sutter A. Differences among international pharyngitis guidelines: not just academic. Annals of Family Medicine 2007;5:436‐43.

RevMan 2014 [Computer program]

The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.

Roos 1995

Roos K, Claesson R, Persson U, Odegaard K. The economic cost of a streptococcal tonsillitis episode. Scandinavian Journal of Primary Health Care 1995;13:257‐60.

Sirimana 1990

Sirimanna KS, Madden GJ, Miles SM. The use of long‐acting penicillin in the prophylaxis of recurrent tonsillitis. Journal of Otolaryngology 1990;100:343‐4.

Spinks 2013

Spinks A, Glasziou PP, Del Mar CB. Antibiotics for sore throat. Cochrane Database of Systematic Reviews 2013, Issue 11. [DOI: 10.1002/14651858.CD000023.pub4]

St Sauver 2006

St Sauver JL, Weaver AL, Orvidas LJ, Jacobson RM, Jacobsen SJ. Population‐based prevalence of repeated group A β‐hemolytic streptococcal pharyngitis episodes. Mayo Clinic Proceedings 2006;81(9):1172‐6.

Characteristics of studies

Characteristics of excluded studies [ordered by study ID]

Study

Reason for exclusion

Jensen 1991

ALLOCATION:
Randomised controlled trial, non‐blinded

PARTICIPANTS:
54 patients with recurrent acute tonsillitis (> 3 episodes in the previous 2 years)

INTERVENTIONS:
150 mg clindamycin 4 times a day for 10 days versus no antibiotic treatment (no placebo used). 28 of the included patients in both arms had a tonsillectomy within the 1‐year period
Excluded because no placebo used and tonsillectomy was used for treatment before follow‐up was complete

Liltholdt 2003

ALLOCATION:
Randomised controlled trial, blinded

PARTICIPANTS:
110 patients (adults and children) with recurrent acute tonsillitis (> 3 episodes in the past 2 years)

INTERVENTIONS:
Azithromycin 500 mg or placebo once a week for 6 months. If any patient had confirmed acute tonsillitis, it was considered failed treatment and they were offered tonsillectomy
Excluded because tonsillectomy was used as treatment before follow‐up was complete

Mora 2003

ALLOCATION:
Randomised controlled trial

PARTICIPANTS:
180 children with recurrent pharyngotonsillitis (at least 3 episodes in the past year)

INTERVENTIONS:
Cefpodoxime proxetil (100 mg twice a day, 6 days a month for 6 months) versus placebo

OUTCOMES:
Authors reported that cefpodoxime may be effective in reducing symptoms of recurrent pharyngotonsillitis and preventing recurrences
Excluded because the results were uninterpretable; we made numerous attempts to contact the investigators but received no response

Sirimanna 1990

ALLOCATION:
Randomised controlled trial, non‐blinded

PARTICIPANTS:
Patients with recurrent tonsillitis (> 4 attacks in the past year)

INTERVENTIONS: intramuscular dose of benzathine penicillin each month for 6 months versus no treatment
Excluded because no treatment was used as a comparison

Process for sifting search results and selecting studies for inclusion
Figuras y tablas -
Figure 1

Process for sifting search results and selecting studies for inclusion

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