Appendix 1. Search strategy for PubMed

1. For Craniopharingioma the following MeSH headings and text words will be used:

craniopharyngioma OR craniopharingiomas OR craniopharingioma* OR Neoplasm, Rathke's Cleft OR Neoplasm, Rathkes Cleft OR Rathke's Pouch Tumor OR Rathkes Pouch Tumor OR Tumor, Rathke's Pouch OR Rathke Pouch Tumor OR Tumor, Rathke Pouch OR Rathke's Cleft Neoplasm OR Rathkes Cleft Neoplasm OR Neoplasm, Rathke Cleft OR Rathke Cleft Neoplasm OR Craniopharyngioma, Papillary OR Craniopharyngiomas, Papillary OR Papillary Craniopharyngioma OR Papillary Craniopharyngiomas OR Craniopharyngioma, Child OR Child Craniopharyngioma OR Child Craniopharyngiomas OR Craniopharyngiomas, Child OR Craniopharyngioma, Adamantinous OR Adamantinous Craniopharyngioma OR Adamantinous Craniopharyngiomas OR Craniopharyngiomas, Adamantinous OR hypophyseal duct tumor OR hypophyseal duct tumors OR adamantinoma OR adamantinomas OR Craniopharyngeal duct tumour OR Adamantinomatous tumour OR Dysodontogenic epithelial tumour

2. For Bleomycin the following MeSH headings and text words will be used:

bleomycin OR bleomycins OR Bleomycin* OR bleo‐cell OR bleo cell OR bellocell OR cell pharm brand of bleomycin sulfate OR bleolem OR lemery brand of bleomycin sulfate OR bleomicina OR almirall brand of bleomycin sulfate OR lundbeck brand of bleomycin sulfate OR bleomycin b2 OR bleomycin b (2) OR bleomycin sulfate OR sulfate, bleomycin OR bull brand of bleomycin sulfate OR bleomycinum mack OR mack, bleomycinum OR mack brand of bleomycin sulfate OR bleomycin bellon OR bellon, bleomycin OR bellon brand of bleomycin sulfate OR blenoxane OR bristol‐myers squibb brand of bleomycin sulfate OR bristol myers squibb brand of bleomycin sulfate OR blenoxane OR bleomycin a2 OR bleomycin a (2) OR cleocin OR bleomycin OR 11056‐06‐7 OR 9041‐93‐4

Final search 1 and 2

[*]=zero to many characters

Appendix 2. Search strategy for Embase (OVID)

1. For craniopharyngioma the following Emtree terms and text words will be used:

1. craniopharyngioma.mp. or exp craniopharyngioma/
2. (craniopharingiomas or craniopharingioma$).mp.
3. Rathke's Pouch Tumor.mp.
4. (Rathkes Pouch Tumor or Rathke Pouch Tumor).mp.
5. (Rathke's Cleft Neoplasm or Rathkes Cleft Neoplasm or Rathke Cleft Neoplasm).mp.
6. exp Rathke cleft cyst/
7. (Papillary Craniopharyngioma or Papillary Craniopharyngiomas).mp.
8. (Child Craniopharyngioma or Child Craniopharyngiomas).mp.
9. (Adamantinous Craniopharyngioma or Adamantinous Craniopharyngiomas).mp.
10. (hypophyseal duct tumor or hypophyseal duct tumors).mp.
11. (adamantinoma or adamantinomas).mp.
12. (craniopharyngeal duct tumour OR adamantinomatous tumour OR dysodontogenic epithelial tumour).mp.
13. or/1‐12

2. For Bleomycin the following Emtree terms and text words will be used:

1. exp bleomycin/
2. (bleomycin or bleomycins or bleomycin$).mp.
3. (bleo‐cell or bleo cell or bellocell).mp.
4. (bleomycin sulfate or bleolem).mp.
5. bleomicina.mp.
6. (bleomycin b2 or bleomycin b 2).mp.
7. (bleomycinum mack or bleomycin bellon).mp.
8. (blenoxane or cleocin).mp.
9. (bleomycin a2 or bleomycin a 2).mp.
10. (11056‐06‐7 or 9041‐93‐4).rn.
11. or/1‐10

Final search: 1 and 2

[mp]=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name
[/]=Emtree term
[$]=zero to many characters
[rn]=registry number

Appendix 3. Search strategy for Central Register of Controlled Trials (CENTRAL)

1. For Craniopharyngioma the following text words will be used:

craniopharyngioma OR craniopharingiomas OR craniopharingioma* OR Rathke's Pouch Tumor OR Rathkes Pouch Tumor OR Rathke Pouch Tumor OR Rathke's Cleft Neoplasm OR Rathkes Cleft Neoplasm OR Rathke Cleft Neoplasm OR Papillary Craniopharyngioma OR Papillary Craniopharyngiomas OR Child Craniopharyngioma OR Child Craniopharyngiomas OR Adamantinous Craniopharyngioma OR Adamantinous Craniopharyngiomas OR hypophyseal duct tumor OR hypophyseal duct tumors OR adamantinoma OR adamantinomas OR craniopharyngeal duct tumour OR adamantinomatous tumour OR dysodontogenic epithelial tumour

2. For Bleomycin the following text words will be used:

bleomycin OR bleomycins OR Bleomycin* OR bleo‐cell OR bleo cell OR bellocell OR cell pharm brand of bleomycin sulfate OR bleolem OR lemery brand of bleomycin sulfate OR bleomicina OR almirall brand of bleomycin sulfate OR lundbeck brand of bleomycin sulfate OR bleomycin b2 OR bleomycin b (2) OR bleomycin sulfate OR sulfate, bleomycin OR bull brand of bleomycin sulfate OR bleomycinum mack OR mack, bleomycinum OR mack brand of bleomycin sulfate OR bleomycin bellon OR bellon, bleomycin OR bellon brand of bleomycin sulfate OR blenoxane OR bristol‐myers squibb brand of bleomycin sulfate OR bristol myers squibb brand of bleomycin sulfate OR blenoxane OR bleomycin a2 OR bleomycin a (2) OR cleocin OR bleomycin

[*]=zero to many characters

Final search: 1 and 2

The search will be performed in title, abstract or keywords