PROSTATIC NEOPLASMS/

(prostat* adj6 (cancer* or carcinom* or tumor* or tumour* or neoplasm* or adenocarcinom*)).ab,ti.

or/1‐2

BRACHYTHERAPY/

brachytherap*.ab,ti.

((interstit* or implant*) adj6 (radiation* or radiotherapy*)).ab,ti.

((seed* or permanent*) adj6 implant*).ab,ti.

or/4‐7

3 and 8

RANDOMIZED CONTROLLED TRIAL.pt.

CONTROLLED CLINICAL TRIAL.pt.

RANDOMIZED CONTROLLED TRIALS AS TOPIC/

RANDOM ALLOCATION/

DOUBLE BLIND METHOD/

SINGLE BLIND METHOD/

or/10‐15

ANIMAL/ not HUMAN/

16 not 17

CLINICAL TRIAL.pt.

exp CLINICAL TRIALS AS TOPIC/

(clinic* adj25 trial*).tw.

((singl* or doubl* or trebl* or tripl*) adj (blind* or mask*)).tw.

PLACEBOS/

placebo*.tw.

random*.tw.

RESEARCH DESIGN/

(latin adj square).tw.

or/19‐27

28 not 17

29 not 18

COMPARATIVE STUDY.pt.

exp EVALUATION STUDIES/

FOLLOW UP STUDIES/

PROSPECTIVE STUDIES/

(control* or prospectiv* or volunteer*).tw.

CROSS‐OVER STUDIES/

or/31‐36

37 not 17

38 not (18 or 30)

18 or 30 or 39

Exp CASE‐CONTROL STUDIES/

exp COHORT STUDIES/

((compare* or comparison* or versus or evaluation or follow up or case‐control*) adj8 (stud* or trial* or analy*)).ab,ti.

((cohort* or observation* or intervention*) adj3 (stud* or trial* or analy*)).ab,ti.

exp CONTROL GROUPS/

exp MULTICENTER STUDIES/

(multi center adj3 stud*).ab,ti.

or/41‐47

40 or 48

search*.tw. or meta analysis.mp,pt. or review.pt.

9 and (49 or 50)

Search prostat* [TIAB] AND (cancer*[TIAB] OR carcinom*[TIAB] OR tumor*[TIAB] OR tumour*[TIAB] OR neoplasm*[TIAB] OR adenocarcinom*[TIAB])

Search brachytherap*

Search (interstit*[TIAB] OR implant* [TIAB]) AND (radiation*[TIAB] OR radiotherapy*[TIAB])

Search (seed*[TIAB] OR permanent* [TIAB]) AND implant*[TIAB]

Search #1 AND (#2 OR #3 OR #4)

Search in process[sb] OR publisher[sb]

Search #5 AND #6