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Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
Figuras y tablas -
Figure 1

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

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Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
Figuras y tablas -
Figure 2

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 1 Perinatal mortality.
Figuras y tablas -
Analysis 1.1

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 1 Perinatal mortality.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 2 Serious perinatal morbidity.
Figuras y tablas -
Analysis 1.2

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 2 Serious perinatal morbidity.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 3 Birth defects.
Figuras y tablas -
Analysis 1.3

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 3 Birth defects.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 4 Caesarean.
Figuras y tablas -
Analysis 1.4

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 4 Caesarean.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 5 Pregnancy‐induced hypertension.
Figuras y tablas -
Analysis 1.5

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 5 Pregnancy‐induced hypertension.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 6 Chronic hypertension.
Figuras y tablas -
Analysis 1.6

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 6 Chronic hypertension.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 7 Self‐monitored blood glucose (mean, mmol/L).
Figuras y tablas -
Analysis 1.7

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 7 Self‐monitored blood glucose (mean, mmol/L).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 8 Self‐monitored blood glucose tests/day.
Figuras y tablas -
Analysis 1.8

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 8 Self‐monitored blood glucose tests/day.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 9 HbA1c (%): first trimester.
Figuras y tablas -
Analysis 1.9

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 9 HbA1c (%): first trimester.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 10 HbA1c (%): second trimester.
Figuras y tablas -
Analysis 1.10

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 10 HbA1c (%): second trimester.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 11 HbA1c (%): third trimester.
Figuras y tablas -
Analysis 1.11

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 11 HbA1c (%): third trimester.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 12 Mean preprandial glucose (mmol/L).
Figuras y tablas -
Analysis 1.12

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 12 Mean preprandial glucose (mmol/L).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 13 Mean postprandial glucose (mmol/L).
Figuras y tablas -
Analysis 1.13

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 13 Mean postprandial glucose (mmol/L).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 14 Percent days below FBG threshold of ≥ 1 result less than:.
Figuras y tablas -
Analysis 1.14

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 14 Percent days below FBG threshold of ≥ 1 result less than:.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 15 More than 1 subjective hypoglycaemic episode (% of days).
Figuras y tablas -
Analysis 1.15

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 15 More than 1 subjective hypoglycaemic episode (% of days).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 16 Maternal weight gain during pregnancy (kg/week).
Figuras y tablas -
Analysis 1.16

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 16 Maternal weight gain during pregnancy (kg/week).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 17 Maternal hospitalisation (days).
Figuras y tablas -
Analysis 1.17

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 17 Maternal hospitalisation (days).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 18 Gestational age (weeks).
Figuras y tablas -
Analysis 1.18

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 18 Gestational age (weeks).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 19 Birthweight (g).
Figuras y tablas -
Analysis 1.19

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 19 Birthweight (g).

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 20 Apgar score.
Figuras y tablas -
Analysis 1.20

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 20 Apgar score.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 21 Fetal distress.
Figuras y tablas -
Analysis 1.21

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 21 Fetal distress.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 22 Asphyxia.
Figuras y tablas -
Analysis 1.22

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 22 Asphyxia.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 23 Neonatal hypocalcaemia.
Figuras y tablas -
Analysis 1.23

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 23 Neonatal hypocalcaemia.

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Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 24 Neonatal hypomagnesaemia.
Figuras y tablas -
Analysis 1.24

Comparison 1 Very tight versus tight‐moderate glycaemic control, Outcome 24 Neonatal hypomagnesaemia.

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Comparison 2 Tight versus moderate glycaemic control, Outcome 1 Perinatal mortality.
Figuras y tablas -
Analysis 2.1

Comparison 2 Tight versus moderate glycaemic control, Outcome 1 Perinatal mortality.

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Comparison 2 Tight versus moderate glycaemic control, Outcome 2 Pre‐eclampsia.
Figuras y tablas -
Analysis 2.2

Comparison 2 Tight versus moderate glycaemic control, Outcome 2 Pre‐eclampsia.

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Comparison 2 Tight versus moderate glycaemic control, Outcome 3 Caesarean section.
Figuras y tablas -
Analysis 2.3

Comparison 2 Tight versus moderate glycaemic control, Outcome 3 Caesarean section.

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Comparison 2 Tight versus moderate glycaemic control, Outcome 4 Maternal hypoglycaemia in first half of pregnancy.
Figuras y tablas -
Analysis 2.4

Comparison 2 Tight versus moderate glycaemic control, Outcome 4 Maternal hypoglycaemia in first half of pregnancy.

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Comparison 2 Tight versus moderate glycaemic control, Outcome 5 Transient maternal hypertension.
Figuras y tablas -
Analysis 2.5

Comparison 2 Tight versus moderate glycaemic control, Outcome 5 Transient maternal hypertension.

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Comparison 2 Tight versus moderate glycaemic control, Outcome 6 Respiratory distress syndrome.
Figuras y tablas -
Analysis 2.6

Comparison 2 Tight versus moderate glycaemic control, Outcome 6 Respiratory distress syndrome.

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Comparison 2 Tight versus moderate glycaemic control, Outcome 7 Birthweight > 90th centile.
Figuras y tablas -
Analysis 2.7

Comparison 2 Tight versus moderate glycaemic control, Outcome 7 Birthweight > 90th centile.

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Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 1 Perinatal mortality.
Figuras y tablas -
Analysis 3.1

Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 1 Perinatal mortality.

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Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 2 Pre‐eclampsia.
Figuras y tablas -
Analysis 3.2

Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 2 Pre‐eclampsia.

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Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 3 Caesarean section.
Figuras y tablas -
Analysis 3.3

Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 3 Caesarean section.

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Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 4 Maternal hypoglycaemia in first half of pregnancy.
Figuras y tablas -
Analysis 3.4

Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 4 Maternal hypoglycaemia in first half of pregnancy.

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Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 5 Transient maternal hypertension.
Figuras y tablas -
Analysis 3.5

Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 5 Transient maternal hypertension.

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Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 6 Respiratory distress syndrome.
Figuras y tablas -
Analysis 3.6

Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 6 Respiratory distress syndrome.

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Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 7 Birthweight > 90th centile.
Figuras y tablas -
Analysis 3.7

Comparison 3 Tight‐moderate versus loose glycaemic control, Outcome 7 Birthweight > 90th centile.

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Comparison 1. Very tight versus tight‐moderate glycaemic control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Perinatal mortality Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Serious perinatal morbidity Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Birth defects Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

3.57 [0.19, 66.61]

3.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

3.57 [0.19, 66.61]

4 Caesarean Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.49, 1.73]

4.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.49, 1.73]

5 Pregnancy‐induced hypertension Show forest plot

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

1.40 [0.60, 3.25]

5.1 FBG target < 4.44 v < 5.55 mmol/L

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

1.40 [0.60, 3.25]

6 Chronic hypertension Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.1 FBG target 3.33 to 5.0 mmol/L v 5.27 to 6.38 mmol/L

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Self‐monitored blood glucose (mean, mmol/L) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

7.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L: first trimester

1

22

Mean Difference (IV, Fixed, 95% CI)

‐1.23 [‐2.19, ‐0.27]

7.2 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L: second trimester

1

22

Mean Difference (IV, Fixed, 95% CI)

‐0.99 [‐1.64, ‐0.34]

7.3 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L: third trimester

1

22

Mean Difference (IV, Fixed, 95% CI)

‐0.66 [‐1.60, 0.28]

8 Self‐monitored blood glucose tests/day Show forest plot

1

22

Mean Difference (IV, Fixed, 95% CI)

1.60 [‐0.15, 3.35]

8.1 FBG target 3.33 to 5.0 v 5.27 to 6.39 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

1.60 [‐0.15, 3.35]

9 HbA1c (%): first trimester Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

9.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

‐1.20 [‐2.25, ‐0.15]

9.2 FBG target < 4.44 v < 5.55 mmol/L

1

137

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐0.62, 0.62]

10 HbA1c (%): second trimester Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

10.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

‐0.5 [‐1.09, 0.09]

10.2 FBG target < 4.44 v < 5.55 mmol/L

1

137

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐0.37, 0.57]

11 HbA1c (%): third trimester Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

11.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

‐0.30 [‐0.92, 0.32]

11.2 FBG target < 4.44 v < 5.55 mmol/L

1

137

Mean Difference (IV, Fixed, 95% CI)

‐0.10 [‐0.49, 0.29]

12 Mean preprandial glucose (mmol/L) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

12.1 FBG target < 4.44 v < 5.55 mmol/L: first trimester

1

137

Mean Difference (IV, Fixed, 95% CI)

‐0.39 [‐1.33, 0.55]

12.2 FBG target < 4.44 v < 5.55 mmol/L: second trimester

1

137

Mean Difference (IV, Fixed, 95% CI)

‐0.27 [‐1.19, 0.65]

12.3 FBG target < 4.44 v < 5.55 mmol/L: third trimester

1

137

Mean Difference (IV, Fixed, 95% CI)

‐0.34 [‐1.40, 0.72]

13 Mean postprandial glucose (mmol/L) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

13.1 FBG target < 4.44 v < 5.55 mmol/L: first trimester

1

137

Mean Difference (IV, Fixed, 95% CI)

‐0.94 [‐2.05, 0.17]

13.2 FBG target < 4.44 v < 5.55 mmol/L: second trimester

1

137

Mean Difference (IV, Fixed, 95% CI)

‐0.56 [‐1.38, 0.26]

13.3 FBG target < 4.44 v < 5.55 mmol/L: third trimester

1

137

Mean Difference (IV, Fixed, 95% CI)

‐0.11 [‐1.26, 1.04]

14 Percent days below FBG threshold of ≥ 1 result less than: Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

14.1 3.33 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

20.0 [7.00, 33.00]

14.2 2.78 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

17.0 [4.04, 29.96]

14.3 < 2.22 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

8.0 [‐3.56, 19.56]

15 More than 1 subjective hypoglycaemic episode (% of days) Show forest plot

1

22

Mean Difference (IV, Fixed, 95% CI)

22.0 [11.07, 32.93]

15.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

22.0 [11.07, 32.93]

16 Maternal weight gain during pregnancy (kg/week) Show forest plot

1

22

Mean Difference (IV, Fixed, 95% CI)

0.02 [‐0.23, 0.27]

16.1 FBG target 3.3 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

0.02 [‐0.23, 0.27]

17 Maternal hospitalisation (days) Show forest plot

1

137

Mean Difference (IV, Fixed, 95% CI)

10.60 [9.53, 11.67]

17.1 FBG target < 4.44 v < 5.55 mmol/L

1

137

Mean Difference (IV, Fixed, 95% CI)

10.60 [9.53, 11.67]

18 Gestational age (weeks) Show forest plot

2

159

Mean Difference (IV, Fixed, 95% CI)

0.43 [‐0.23, 1.08]

18.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

‐0.30 [‐2.44, 1.84]

18.2 FBG target < 4.44 v < 5.55 mmol/L

1

137

Mean Difference (IV, Fixed, 95% CI)

0.5 [‐0.19, 1.19]

19 Birthweight (g) Show forest plot

2

159

Mean Difference (IV, Fixed, 95% CI)

‐2.62 [‐179.83, 174.59]

19.1 FBG target 3.33 to 5.0 v 5.27 to 6.38 mmol/L

1

22

Mean Difference (IV, Fixed, 95% CI)

‐272.0 [‐803.99, 259.99]

19.2 FBG target < 4.44 v < 5.55 mmol/L

1

137

Mean Difference (IV, Fixed, 95% CI)

31.0 [‐156.95, 218.95]

20 Apgar score Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

20.1 < 7 at 1 minute: FBG target < 4.44 v < 5.55 mmol/L

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.40, 2.55]

20.2 < 7 at 5 minutes: FBG target < 4.44 v < 5.55 mmol/L

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

21 Fetal distress Show forest plot

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.63, 2.11]

21.1 FBG target < 4.44 v < 5.55 mmol/L

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.63, 2.11]

22 Asphyxia Show forest plot

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.58, 1.78]

22.1 FBG target < 4.44 v < 5.55 mmol/L

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.58, 1.78]

23 Neonatal hypocalcaemia Show forest plot

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

0.55 [0.30, 1.03]

23.1 FBG target < 4.44 v < 5.55 mmol/L

1

137

Risk Ratio (M‐H, Fixed, 95% CI)

0.55 [0.30, 1.03]

24 Neonatal hypomagnesaemia Show forest plot

1

127

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.25, 1.68]

24.1 FBG target < 4.44 v < 5.55 mmol/L

1

127

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.25, 1.68]
Figuras y tablas -
Comparison 1. Very tight versus tight‐moderate glycaemic control
Ir a la tabla de la revisión
Comparison 2. Tight versus moderate glycaemic control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Perinatal mortality Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.1 FBG target ≤ 5.6 v 5.6 to 6.7 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Pre‐eclampsia Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

5.29 [0.23, 122.91]

2.1 FBG target ≤ 5.6 mmol/L v 5.6 to 6.7 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

5.29 [0.23, 122.91]

3 Caesarean section Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [0.22, 6.50]

3.1 FBG target ≤ 5.6 v 5.6 to 6.7 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [0.22, 6.50]

4 Maternal hypoglycaemia in first half of pregnancy Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

26.47 [1.61, 435.38]

4.1 FBG target ≤ 5.6 v 5.6 to 6.7 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

26.47 [1.61, 435.38]

5 Transient maternal hypertension Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.59 [0.03, 13.66]

5.1 FBG target ≤ 5.6 v 5.6 to 6.7 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.59 [0.03, 13.66]

6 Respiratory distress syndrome Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.09, 9.24]

6.1 FBG target ≤ 5.6 v 5.6 to 6.7 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.09, 9.24]

7 Birthweight > 90th centile Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.1 FBG target ≤ 5.6 v 5.6 to 6.7 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 2. Tight versus moderate glycaemic control
Ir a la tabla de la revisión
Comparison 3. Tight‐moderate versus loose glycaemic control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Perinatal mortality Show forest plot

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.07 [0.00, 1.37]

1.1 FBG target ≤ 6.7 v 6.7 to 8.9 mmol/L

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.07 [0.00, 1.37]

2 Pre‐eclampsia Show forest plot

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.11 [0.01, 0.99]

2.1 FBG ≤ 6.7 mmol/L v 6.7 to 8.9 mmol/L

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.11 [0.01, 0.99]

3 Caesarean section Show forest plot

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.28 [0.10, 0.78]

3.1 FBG target ≤ 6.7 v 6.7 to 8.9 mmol/L

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.28 [0.10, 0.78]

4 Maternal hypoglycaemia in first half of pregnancy Show forest plot

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

5.22 [0.32, 86.28]

4.1 FBG target ≤ 6.7 v 6.7 to 8.9 mmol/L

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

5.22 [0.32, 86.28]

5 Transient maternal hypertension Show forest plot

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

1.81 [0.12, 27.07]

5.1 FBG target ≤ 6.7 v 6.7 to 8.9 mmol/L

1

45

Risk Ratio (M‐H, Fixed, 95% CI)

1.81 [0.12, 27.07]

6 Respiratory distress syndrome Show forest plot

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.17 [0.05, 0.59]

6.1 FBG target ≤ 6.7 v 6.7 to 8.9 mmol/L

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.17 [0.05, 0.59]

7 Birthweight > 90th centile Show forest plot

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.01 [0.00, 0.20]

7.1 FBG target ≤ 6.7 v 6.7 to 8.9 mmol/L

1

60

Risk Ratio (M‐H, Fixed, 95% CI)

0.01 [0.00, 0.20]
Figuras y tablas -
Comparison 3. Tight‐moderate versus loose glycaemic control
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