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'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 1

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
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Figure 2

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

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Forest plot of comparison: 1 Amitriptyline versus placebo, outcome: 1.1 Second‐tier efficacy.
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Figure 3

Forest plot of comparison: 1 Amitriptyline versus placebo, outcome: 1.1 Second‐tier efficacy.

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L'Abbé plot of second‐tier outcome for amitriptyline 25 or 50 mg and placebo in fibromyalgia. Each circle represents one study. Size of circle is proportional to size of study (inset scale).
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Figure 4

L'Abbé plot of second‐tier outcome for amitriptyline 25 or 50 mg and placebo in fibromyalgia. Each circle represents one study. Size of circle is proportional to size of study (inset scale).

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Bimodal distribution of benefits with amitriptyline and placebo in neuropathic pain and fibromyalgia
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Figure 5

Bimodal distribution of benefits with amitriptyline and placebo in neuropathic pain and fibromyalgia

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Relationship between NNT and total size of study
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Figure 6

Relationship between NNT and total size of study

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Comparison 1 Amitriptyline versus placebo, Outcome 1 Second‐tier efficacy.
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Analysis 1.1

Comparison 1 Amitriptyline versus placebo, Outcome 1 Second‐tier efficacy.

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Comparison 1 Amitriptyline versus placebo, Outcome 2 At least 1 adverse event.
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Analysis 1.2

Comparison 1 Amitriptyline versus placebo, Outcome 2 At least 1 adverse event.

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Comparison 1 Amitriptyline versus placebo, Outcome 3 All‐cause withdrawal.
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Analysis 1.3

Comparison 1 Amitriptyline versus placebo, Outcome 3 All‐cause withdrawal.

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Comparison 1 Amitriptyline versus placebo, Outcome 4 Adverse event withdrawal.
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Analysis 1.4

Comparison 1 Amitriptyline versus placebo, Outcome 4 Adverse event withdrawal.

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Comparison 1 Amitriptyline versus placebo, Outcome 5 Lack of efficacy withdrawal.
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Analysis 1.5

Comparison 1 Amitriptyline versus placebo, Outcome 5 Lack of efficacy withdrawal.

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Comparison 1. Amitriptyline versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Second‐tier efficacy Show forest plot

11

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 Painful diabetic neuropathy

2

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 Postherpetic neuralgia

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.3 Mixed neuropathic pain

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.4 Cancer‐related neuropathic pain

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.5 HIV‐related neuropathic pain

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.6 Post‐stroke pain

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.7 Fibromyalgia

4

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 At least 1 adverse event Show forest plot

10

837

Risk Ratio (M‐H, Fixed, 95% CI)

1.54 [1.37, 1.74]

3 All‐cause withdrawal Show forest plot

8

644

Risk Ratio (M‐H, Fixed, 95% CI)

1.00 [0.74, 1.36]

4 Adverse event withdrawal Show forest plot

6

575

Risk Ratio (M‐H, Fixed, 95% CI)

1.72 [1.01, 2.92]

5 Lack of efficacy withdrawal Show forest plot

4

440

Risk Ratio (M‐H, Fixed, 95% CI)

0.38 [0.19, 0.76]
Figuras y tablas -
Comparison 1. Amitriptyline versus placebo
Ir a la tabla de la revisión