Study ID

Participants

Intervention

Control

Outcomes

Note

Eberhart 2008

Ovarian cancer undergoing major abdominal surgery

The multimodal fast‐track algorithm group (N = 46)

The traditional algorithm group (N = 40)

• PPP33‐questionnaire (a quality of life tool)

• Recovery

• Postoperative complications

The full text could not be retrieved

Gerardi 2008

FIGO Stages II‐IV epithelial ovarian or primary peritoneal cancer undergoing primary cytoreductive surgery.

The postoperative management dictated by a prescribed clinical pathway (N = 19)

The postoperative management dictated by a prescribed clinical pathway (N = 45)

• Time to flatus

• Time to tolerance of diet

• ICU stay

• Postoperative complications

• Length of hospital stay

• Hospital cost

• 30‐day re‐admission rate

The clinical pathway included rapid diet advancement, early discontinuance of nasogastric suction, criteria‐based utilisation of parenteral nutrition, selective laboratory testing and deferring initiation of chemotherapy until after discharge

Marx 2006

Ovarian cancer undergoing surgery

Perioperative multimodal rehabilitation (N = 69)

Perioperative conventional care (N = 72)

• Postoperative complications

• Re‐operations

• Re‐admissions

• Mortality

• Primary hospital stay

Multimodal rehabilitation included: no preoperative sedatives, no bowel preparation, continuous epidural analgesia, no nasogastric tube, early oral feeding, early mobilisation

Outcomes

Eberhart 2008

Gerardi 2008

Marx 2006

Primary outcomes

Length of hospital stay (days)

‐

Intervention group: 7.0

(95% CI 3 to 27)
Control group: 10.0

(95% CI 5 to 30)
P = 0.010

Intervention group: 5

(95% CI 2 to 31)
Control group: 6

(95% CI 2 to 64)
P < 0.05

Postoperative complications

"rare and did not differ between both groups"

Intervention group: 57.9%
Control group: 62.2%
P = 0.746

Intervention group: 24.6%
Control group: 31.9%
P > 0.05

Early and late mortality

‐

Only 1 mortality in control group at day 17

Intervention group: 0%
Control group: 2.8%
P > 0.05

Secondary outcomes

Re‐admission rate

‐

Intervention group: 21.1%
Control group: 33.3%
P = 0.326

Intervention group: 2.9%
Control group: 12.5%
P > 0.05

Time to flatus (days)

"Patients in fast‐track group rated their recovery to be faster than patients treated by the traditional concept"

Intervention group: 6.0

(95% CI 4 to 20)
Control group: 6.0

(95% CI 2 to 15)
P = 0.630

‐

Time to tolerance of diet (days)

‐

Intervention group: 3.0

(95% CI 1 to 20)
Control group: 6.0

(95% CI 1 to 14)
P = 0.013

‐

QoL

"Several dimensions of the PPP33‐questionnaire ("autonomy", "physical complaints", and "postoperative pain") were improved by the multimodal "fast‐track" rehabilitation programme"

‐

‐

Cost

‐

Intervention group: 19,700

(95% CI 11,010 to 84,170)
Control group: 25,110

(95% CI 11,980 to 78,150)
P = 0.043 *

‐

Re‐operation

‐

‐

Intervention group: 4.3%
Control group: 12.5%
P > 0.05