Single dose oral gabapentin for established acute postoperative pain in adults

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Figure 1

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

Figure 2

Forest plot of comparison: 1 Gabapentin 250 mg versus placebo, outcome: 1.1 Participants with ≥50% pain relief over 6 hours.

Figure 3

Forest plot of comparison: 1 Gabapentin 250 mg versus placebo, outcome: 1.2 Use of rescue medication within 6 hours.

Figure 4

Forest plot of comparison: 1 Gabapentin 250 mg versus placebo, outcome: 1.3 Participants with ≥ adverse event.

Analysis 1.1

Comparison 1 Gabapentin 250 mg versus placebo, Outcome 1 Participants with ≥50% pain relief over 6 hours.

Analysis 1.2

Comparison 1 Gabapentin 250 mg versus placebo, Outcome 2 Use of rescue medication within 6 hours.

Analysis 1.3

Comparison 1 Gabapentin 250 mg versus placebo, Outcome 3 Participants with ≥1 adverse event.

Comparison 1. Gabapentin 250 mg versus placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Participants with ≥50% pain relief over 6 hours Show forest plot	3	329	Risk Ratio (M‐H, Fixed, 95% CI)	2.46 [1.20, 5.03]

2 Use of rescue medication within 6 hours Show forest plot	3	329	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.72, 0.91]

3 Participants with ≥1 adverse event Show forest plot	3	329	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.66, 1.25]

Comparison 1. Gabapentin 250 mg versus placebo