Appendix 1. MEDLINE search strategy

Database: Ovid MEDLINE(R)

Search Strategy:

‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐‐

1     exp Angiotensin‐Converting Enzyme Inhibitors/

2     ((angiotensin or dipeptidyl) adj3 (convert$ or enzyme or inhibit$ or recept$ or block$)).tw.

3     ((ace or renin) adj3 inhibit$).tw.

4     acei.tw.

5     captopril/

6     cilazapril/

7     exp enalapril/

8     fosinopril/

9     lisinopril/

10     perindopril/

11     ramipril/

12     (alacepril or altiopril or benazepril or captopril or ceronapril or cilazapril or delapril or enalapril or fosinopril or idapril or imidapril or lisinopril or moexipril or moveltipril or pentopril or perindopril or quinapril or ramipril or spirapril or temocapril or trandolapril or zofenopril).mp.

13     exp losartan/

14     (KT3‐671 or candesartan or eprosartan or irbesartan or losartan or olmesartan or tasosartan or telmisartan or valsartan or aliskiren or remikiren).mp.

15     or/1‐14

16     (calcium channel block$ or amlodipine or amrinone or bencyclane or bepridil or cinnarizine or conotoxins or diltiazem or felodipine or fendiline or flunarizine or gallopamil or isradipine or lidoflazine or magnesium sulfate or mibefradil or nicardipine or nifedipine or nimodipine or nisoldipine or nitrendipine or perhexiline or prenylamine or verapamil or omega‐agatoxin iva or omega‐conotoxin gvia or omega‐conotoxins).mp.

17     (calcium adj2 (inhibit$ or antagonist? or block$)).tw.

18     16 or 17  

19     (methyldopa or alphamethyldopa or amodopa or dopamet or dopegyt or dopegit or dopegite or emdopa or hyperpax or hyperpaxa or methylpropionic acid or dopergit or meldopa or methyldopate or medopa or medomet or sembrina or aldomet or aldometil or aldomin or hydopa or methyldihydroxyphenylalanine or methyl dopa or mulfasin or presinol or presolisin or sedometil or sembrina or taquinil or dihydroxyphenylalanine or methylphenylalanine or methylalanine or alpha methyl dopa).mp.

20     (reserpine or serpentina or rauwolfia or serpasil).mp.

21     (clonidine or adesipress or arkamin or caprysin or catapres$ or catasan or chlofazolin or chlophazolin or clinidine or clofelin$ or clofenil or clomidine or clondine or clonistada or clonnirit or clophelin$ or dichlorophenylaminoimidazoline or dixarit or duraclon or gemiton or haemiton or hemiton or imidazoline or isoglaucon or klofelin or klofenil or m‐5041t or normopresan or paracefan or st‐155 or st 155 or tesno timelets).mp.

22     exp hydralazine/

23     (hydralazin$ or hydrallazin$ or hydralizine or hydrazinophtalazine or hydrazinophthalazine or hydrazinophtalizine or dralzine or hydralacin or hydrolazine or hypophthalin or hypoftalin or hydrazinophthalazine or idralazina or 1‐hydrazinophthalazine or apressin or nepresol or apressoline or apresoline or apresolin or alphapress or alazine or idralazina or lopress or plethorit or praeparat).mp.

24     or/19‐23

25     exp adrenergic beta‐antagonists/

26     adrenergic beta antagonist?.tw.

27     (acebutolol or adimolol or afurolol or alprenolol or amosulalol or arotinolol or atenolol or befunolol or betaxolol or bevantolol or bisoprolol or bopindolol or bornaprolol or brefonalol or bucindolol or bucumolol or bufetolol or bufuralol or bunitrolol or bunolol or bupranolol or butofilolol or butoxamine or carazolol or carteolol or carvedilol or celiprolol or cetamolol or chlortalidone cloranolol or cyanoiodopindolol or cyanopindolol or deacetylmetipranolol or diacetolol or dihydroalprenolol or dilevalol or epanolol or esmolol or exaprolol or falintolol or flestolol or flusoxolol or hydroxybenzylpinodolol or hydroxycarteolol or hydroxymetoprolol or indenolol or iodocyanopindolol or iodopindolol or iprocrolol or isoxaprolol or labetalol or landiolol or levobunolol or levomoprolol or medroxalol or mepindolol or methylthiopropranolol or metipranolol or metoprolol or moprolol or nadolol or oxprenolol or penbutolol or pindolol or nadolol or nebivolol or nifenalol or nipradilol or oxprenolol or pafenolol or pamatolol or penbutolol or pindolol or practolol or primidolol or prizidilol or procinolol or pronetalol or propranolol or proxodolol or ridazolol or salcardolol or soquinolol or sotalol or spirendolol or talinolol or tertatolol or tienoxolol or tilisolol or timolol or tolamolol or toliprolol or tribendilol or xibenolol).mp.

28     (beta adj2 (antagonist? or receptor? or adrenergic? block$)).tw.

29     or/25‐28  

30     exp adrenergic alpha antagonists/

31     (alfuzosin or bunazosin or doxazosin or metazosin or neldazosin or prazosin or silodosin or tamsulosin or terazosin or tiodazosin or trimazosin).mp.

32     (andrenergic adj2 (alpha or antagonist?)).tw.

33     ((andrenergic or alpha or receptor?) adj2 block$).tw.

34     or/30‐33

35     exp thiazides/

36     exp sodium potassium chlorid symporter inhibitors/

37     ((loop or ceiling) adj diuretic?).mp.

38     (amiloride or benzothiadiazine or bendroflumethiazide or bumetanide or chlorothiazide or cyclopenthiazide or furosemide or hydrochlorothiazide or hydroflumethiazide or methyclothiazide or metolazone or polythiazide or trichlormethiazide or veratide or thiazide?).mp.

39     (chlorthalidone or chlortalidone or phthalamudine or chlorphthalidolone or oxodoline or thalitone or hygroton or indapamide or metindamide or s‐1520 or s1520 or se‐1520 or se1520).mp.

40     or/35‐39

41     exp hypertension/

42     hypertens$.tw.

43     exp blood pressure/

44     blood pressure.mp.

45     bloodpressure.tw.

46     or/41‐45

47     randomized controlled trial.pt.

48     controlled clinical trial.pt.

49     random$.mp.

50     parallel.tw.

51     trial.tw.

52     groups.ab.

53     dt.fs.

54     (doubl$ adj3 blind$).mp.

55     or/47‐54

56     animals/ not (humans/ and animals/)

57     55 not 56

58     15 and 46 and 57 and (18 or 24 or 29 or 34 or 40)

59     (versus or compar$ or between or either).tw.

60     58 and 59

61     limit 60 to yr="2005 ‐ 2009"