Appendix 1. CRS Web search strategy

1. (Subpial AND transection*):AB,KW,MC,MH,TI AND CENTRAL:TARGET

2. MESH DESCRIPTOR Epilepsy EXPLODE ALL AND CENTRAL:TARGET

3. MESH DESCRIPTOR Seizures EXPLODE ALL AND CENTRAL:TARGET

4. (epilep* OR seizure* OR convuls*):AB,KW,MC,MH,TI AND CENTRAL:TARGET

5. #2 OR #3 OR #4 AND CENTRAL:TARGET

6. #1 AND #5 AND CENTRAL:TARGET

Appendix 2. MEDLINE search strategy

This strategy is based on the Cochrane Highly Sensitive Search Strategy for identifying randomized trials (Lefebvre 2011).

1. (Subpial and transection$).tw.

2. exp Epilepsy/

3. exp Seizures/

4. (epilep$ or seizure$ or convuls$).tw.

5. 2 or 3 or 4

6. exp *Pre‐Eclampsia/ or exp *Eclampsia/

7. 5 not 6

8. (randomized controlled trial or controlled clinical trial or pragmatic clinical trial).pt. or (randomi?ed or placebo or randomly).ab.

9. clinical trials as topic.sh.

10. trial.ti.

11. 8 or 9 or 10

12. exp animals/ not humans.sh.

13. 11 not 12

14. 1 and 7 and 13

15. remove duplicates from 14

Appendix 3. ClinicalTrials.gov search strategy

Interventional Studies | Epilepsy | subpial transection

Appendix 4. ICTRP search strategy

subpial transection AND epilepsy