Daclizumab for relapsing remitting multiple sclerosis
Appendices
Appendix 1. CENTRAL search strategy
#1MeSH descriptor Multiple Sclerosis explode all trees
#2MeSH descriptor Demyelinating Diseases, this term only
#3MeSH descriptor Myelitis, Transverse, this term only
#4MeSH descriptor Optic Neuritis explode all trees
#5MeSH descriptor Encephalomyelitis, Acute Disseminated, this term only
#6(multiple sclerosis)
#7(demyelinating disease*)
#8(transverse myelitis)
#9(neuromyelitis optica)
#10(optic neuritis)
#11(encephalomyelitis acute disseminated)
#12(devic)
#13(#1 OR #1 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12)
#14interferon* OR "glatiramer acetate" OR copolymer* OR avonex OR rebif OR betaferon OR betaseron OR copaxone OR corticosteroid* OR steroids OR methotrexate OR mitoxantrone OR azathioprine OR cyclophosphamide OR "disease modifying drugs" OR immunoglobulin*
#15 MeSH descriptor Immunoglobulins explode all trees
#16 daclizumab OR antigen OR zenapax
#17(#14 OR #15)
#18(#13 AND ( #16 AND #17 ))
Appendix 2. MEDLINE (PubMed) search strategy
(((interferon* OR "glatiramer acetate" OR copolymer*) OR ("Immunoglobulins"[Mesh]) OR (immunoglobulin*) OR (avonex OR rebif OR betaferon OR betaseron OR copaxone OR azathioprine OR corticosteroid* OR steroids OR methotrexate OR mitoxantrone OR cyclophosphamide OR "disease modifying drugs")) AND ((daclizumab OR antigen OR zenapax) OR ("daclizumab "[Substance Name]))) AND (((("Multiple Sclerosis"[mh]) OR ("Myelitis, Transverse"[mh:noexp]) OR ("Demyelinating Diseases"[mh:noexp]) OR ("Encephalomyelitis, Acute Disseminated"[mh:noexp]) OR ("Optic Neuritis"[mh])) OR ((("multiple sclerosis") OR ("neuromyelitis optica") OR ("transverse myelitis") OR (encephalomyelitis) OR (devic) OR ("optic neuritis")) OR ("demyelinating disease*") OR ("acute disseminated encephalomyelitis"))) AND (((randomized controlled trial[pt]) OR (controlled clinical trial[pt]) OR (randomized[tiab]) OR (placebo[tiab]) OR (drug therapy[sh]) OR (randomly[tiab]) OR (trial[tiab]) OR (groups[tiab])) NOT ((animals[mh]) NOT ((animals[mh]) AND (human[mh])))))
Appendix 3. EMBASE search strategy
('encephalomyelitis'/exp OR 'demyelinating disease'/exp OR 'multiple sclerosis'/exp OR 'myelooptic neuropathy'/exp OR 'multiple sclerosis':ab,ti OR 'neuromyelitis optica':ab,ti OR encephalomyelitis:ab,ti OR devic:ab,ti) AND ('crossover procedure'/exp OR 'double blind procedure'/exp OR 'controlled clinical trial'/exp OR 'single blind procedure'/exp OR 'randomized controlled trial'/exp OR random*:ab,ti OR factorial*:ab,ti OR crossover:ab,ti OR (cross:ab,ti AND over:ab,ti) OR placebo:ab,ti OR 'double blind':ab,ti OR 'single blind':ab,ti OR assign*:ab,ti OR allocat*:ab,ti OR volunteer*:ab,ti) AND ('daclizumab'/exp OR antegren:ab,ti OR zenapax:ab,ti OR daclizumab:ab,ti) AND (interferon*:ab,ti OR 'glatiramer acetate':ab,ti OR copolymer*:ab,ti OR 'immunoglobulins'/exp OR 'intravenous'/exp OR immunoglobulin*:ab,ti OR azathioprine:ab,ti OR avonex:ab,ti OR rebif:ab,ti OR copaxone:ab,ti OR betaseron:ab,ti OR betaferon:ab,ti OR corticosteroid*:ab,ti OR steroids:ab,ti OR methotrexate:ab,ti OR mitoxantrone:ab,ti OR cyclophosphamide:ab,ti OR 'disease modifying drugs':ab,ti) AND [humans]/lim AND [embase]/lim
