Кортикостероиды при простуде
Appendices
Appendix 1. MEDLINE and CENTRAL search strategy
1 Common Cold/ (3092)
2 common cold*.tw. (2266)
3 coryza.tw. (333)
4 Respiratory Tract Infections/ (27457)
5 upper respiratory tract infection*.tw. (3093)
6 upper respiratory infection*.tw. (1605)
7 (uri or urti).tw. (795)
8 Epiglottitis/ (826)
9 epiglottitis.tw. (1100)
10 Rhinitis/ (7046)
11 rhinitis.tw. (15548)
12 Nasopharyngitis/ (227)
13 (rhinopharyngitis or nasopharyngitis).tw. (354)
14 Nasal Obstruction/ (2895)
15 Sneezing/ (674)
16 (rhinorrhoea or rhinorrhoea).tw. (2839)
17 ((nasal or nose*) adj2 (runny or running or congest* or blocked or discharg*)).tw. (2790)
18 Rhinovirus/ (2389)
19 rhinovir*.tw. (2747)
20 coronavirus/ or coronavirus 229e, human/ or coronavirus nl63, human/ or coronavirus oc43, human/ (1001)
21 coronavir*.tw. (5880)
22 Adenoviruses, Human/ (5968)
23 adenoviridae infections/ or adenovirus infections, human/ (5437)
24 adenovir*.tw. (35954)
25 Picornaviridae Infections/ (1023)
26 Enterovirus Infections/ (3197)
27 Coxsackievirus Infections/ (3252)
28 Echovirus Infections/ (917)
29 enterovirus/ or enterovirus a, human/ or exp enterovirus b, human/ or enterovirus c, human/ or enterovirus d, human/ (8810)
30 (pircornavir* or enterovir* or echovir* or coxsackie*).tw. (10659)
31 respiratory syncytial viruses/ or respiratory syncytial virus, human/ (5432)
32 Respiratory Syncytial Virus Infections/ (3715)
33 (respiratory syncytial virus infection* or rsv).tw. (6792)
34 parainfluenza virus 2, human/ or parainfluenza virus 4, human/ (246)
35 parainfluenza virus 1, human/ or parainfluenza virus 3, human/ (3514)
36 parainfluenza*.tw. (4196)
37 Epstein‐Barr Virus Infections/ (4070)
38 (epstein‐barr or epstein barr or ebv).tw. (25436)
39 Orthomyxoviridae/ (9572)
40 Orthomyxoviridae Infections/ (5322)
41 exp Influenzavirus A/ (21562)
42 exp Influenzavirus B/ (2514)
43 Influenzavirus C/ (260)
44 (influenzavirus* or influenza virus*).tw. (18748)
45 orthomyxovir*.tw. (303)
46 Paramyxoviridae Infections/ (2177)
47 paramyxovir*.tw. (2411)
48 Cytomegalovirus Infections/ (17819)
49 cytomegalovir*.tw. (28732)
50 simplexvirus/ or herpesvirus 1, human/ (22653)
51 Herpesvirus 4, Human/ (18492)
52 or/1‐51 (238889)
53 exp Glucocorticoids/ (144252)
54 glucocorticoid*.tw,nm. (70536)
55 exp Hydroxycorticosteroids/ (114224)
56 hydroxycorticosteroid*.tw,nm. (6472)
57 exp Pregnenediones/ (151889)
58 pregnenedione*.tw,nm. (1896)
59 pregnenolone*.tw,nm. (6061)
60 hydrocortisone.tw,nm. (60234)
61 hydroxypregnenolone.tw,nm. (846)
62 tetrahydrocortisol.tw,nm. (424)
63 cortodoxone.tw,nm. (746)
64 cortisone.tw,nm. (17357)
65 corticosterone.tw,nm. (25049)
66 triamcinolone.tw,nm. (8007)
67 prednisone.tw,nm. (39528)
68 prednisolone.tw,nm. (33196)
69 paramethasone.tw,nm. (218)
70 methylprednisolone.tw,nm. (18039)
71 dexamethasone.tw,nm. (50373)
72 clobetasol.tw,nm. (1031)
73 beclomethasone.tw,nm. (3165)
74 betamethasone.tw,nm. (5764)
75 budesonide.tw,nm. (3773)
76 corticosteroid*.tw,nm. (61498)
77 steroid*.tw,nm. (223268)
78 (efcortesol or hydrocortone or solu‐cortef).tw,nm. (25)
79 (betnelan or betnesol).tw,nm. (25)
80 (deflazacort or calcort).tw,nm. (389)
81 (medrone or solu‐medrone or depo‐medrone).tw,nm. (12)
82 kenalog.tw,nm. (148)
83 (novolizer or pulmicort or symbicort).tw,nm. (248)
84 (beclometasone or aerobec or asmabec or beclazone or becodisks or becotide or clenil modulite or qvar or becloforte).tw,nm. (221)
85 or/53‐84 (530327)
86 52 and 85 (8306)
87 randomized controlled trial.pt. (299024)
88 controlled clinical trial.pt. (81706)
89 randomized.ab. (206825)
90 placebo.ab. (121696)
91 clinical trials as topic.sh. (152139)
92 randomly.ab. (150335)
93 trial.ti. (88765)
94 87 or 88 or 89 or 90 or 91 or 92 or 93 (696129)
95 exp animals/ not humans.sh. (3533521)
96 94 not 95 (643057)
97 86 and 96 (1372)
Appendix 2. EMBASE.com search strategy
#58. #54 AND #57 3,854 25 Feb 2011
#57. #55 OR #56 912,654 25 Feb 2011
#56. random*:ab,ti OR placebo* OR factorial*:ab,ti OR crossover*:ab,ti OR 'cross over':ab,ti OR 'cross‐over':ab,ti OR volunteer*:ab,ti OR assign*:ab,ti OR allocat*:ab,ti OR ((singl* OR doubl*) NEAR/1 blind*):ab,ti AND [embase]/lim 881,603 25 Feb 2011
#55. 'randomized controlled trial'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover procedure'/exp AND [embase]/lim 237,517 25 Feb 2011
#54. #41 AND #53 18,703 25 Feb 2011
#53. #42 OR #43 OR #44 OR #45 OR #46 OR #47 OR #48 OR #49 OR #50 OR #51 OR #52 620,492 25 Feb 2011
#52. beclometasone:ab,ti OR aerobec:ab,ti OR asmabec:ab,ti OR beclazone:ab,ti OR becodisks:ab,ti OR becotide:ab,ti OR 'clenil modulite':ab,ti OR qvar:ab,ti OR becloforte:ab,ti AND [embase]/lim 421 25 Feb 2011
#51. novolizer:ab,ti OR pulmicort:ab,ti OR symbicort:ab,ti AND [embase]/lim 292 25 Feb 2011
#50. kenalog:ab,ti AND [embase]/lim 117 25 Feb 2011
#49. medrone:ab,ti OR 'solu‐medrone':ab,ti OR 'depo‐medrone':ab,ti AND [embase]/lim 14 25 Feb 2011
#48. deflazacort:ab,ti OR calcort:ab,ti AND [embase]/lim 394 25 Feb 2011
#47. efcortesol:ab,ti OR hydrocortone:ab,ti OR 'solu cortef':ab,ti OR betnelan:ab,ti OR betnesol:ab,ti AND [embase]/lim 49 25 Feb 2011
#46. steroid*:ab,ti OR hydrocortisone:ab,ti OR hydroxypregnenolone:ab,ti OR pregnenolone:ab,ti OR tetrahydrocortisol:ab,ti OR cortodoxone:ab,ti OR cortisone:ab,ti OR corticosterone:ab,ti OR
triamcinolone:ab,ti OR prednisone:ab,ti OR prednisolone:ab,ti OR paramethasone:ab,ti OR methylprednisolone:ab,ti OR dexamethasone:ab,ti OR clobetasol:ab,ti OR beclomethasone:ab,ti OR
beclometasone:ab,ti OR betamethasone:ab,ti OR budesonide:ab,ti AND [embase]/lim 255,337 25 Feb 2011
#45. 'cortodoxone'/de AND [embase]/lim 1,260 25 Feb 2011
#44. 'pregnane derivative'/de AND [embase]/lim 528 25 Feb 2011
#43. corticosteroid*:ab,ti OR glucocorticoid*:ab,ti OR hydrocorticosteroid*:ab,ti OR hyroxcorticosteroid*:ab,ti AND [embase]/lim 105,815 25 Feb 2011
#42. 'corticosteroid'/exp AND [embase]/lim 495,099 25 Feb 2011
#41. #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38 OR #39 OR #40 164,080 25 Feb 2011
#40. 'herpes simplex virus 1'/de AND [embase]/lim 12,865 25 Feb 2011
#39. 'simplexvirus'/de AND [embase]/lim 3 25 Feb 2011
#38. cytomegalovir*:ab,ti AND [embase]/lim 27,461 25 Feb 2011
#37. 'cytomegalovirus infection'/de AND [embase]/lim 16,718 25 Feb 2011
#36. paramyxovir*:ab,ti AND [embase]/lim 1,988 25 Feb 2011
#35. 'paramyxovirus infection'/de AND [embase]/lim 9 25 Feb 2011
#34. influenzavir*:ab,ti OR 'influenza virus':ab,ti OR 'influenza viruses':ab,ti AND [embase]/lim 9 25 Feb 2011
#33. 'influenza virus a'/exp OR 'influenza virus b'/de OR 'influenza virus c'/de AND [embase]/lim 15,442 25 Feb 2011
#32. orthomyxovir*:ab,ti AND [embase]/lim 249 25 Feb 2011
#31. 'orthomyxovirus infection'/de OR 'orthomyxovirus'/de AND [embase]/lim 638 25 Feb 2011
#30. 'epstein barr':ab,ti OR 'epstein‐barr':ab,ti OR ebv:ab,ti AND [embase]/lim 24,877 25 Feb 2011
#29. 'epstein barr virus infection'/de AND [embase]/lim 522 25 Feb 2011
#28. parainfluenza*:ab,ti AND [embase]/lim 3,453 25 Feb 2011
#27. 'parainfluenza virus'/exp AND [embase]/lim 4,200 25 Feb 2011
#26. 'respiratory syncytial virus':ab,ti OR 'respiratory syncytial viruses':ab,ti OR rsv:ab,ti AND [embase]/lim 9,130 25 Feb 2011
#25. 'respiratory syncytial pneumovirus'/de OR 'respiratory syncytial virus infection'/de AND [embase]/lim 8,874 25 Feb 2011
#24. picornavir*:ab,ti OR enterovir*:ab,ti OR echovir*:ab,ti OR coxsackie*:ab,ti AND [embase]/lim AND [2007‐2011]/py 2,146 25 Feb 2011
#23. 'picornavirus infection'/de OR 'enterovirus infection'/de OR 'coxsackie virus infection'/de OR 'echovirus infection'/de AND [embase]/lim AND [2007‐2011]/py 538 25 Feb 2011
#22. adenovir*:ab,ti AND [embase]/lim AND 8,654 25 Feb 2011 [2007‐2011]/py
#21. 'human adenovirus infection'/de AND [embase]/lim AND [2007‐2011]/py 19 25 Feb 2011
#20. 'human adenovirus'/exp AND [embase]/lim AND [2007‐2011]/py 290 25 Feb 2011
#19. coronavir*:ab,ti AND [embase]/lim AND [2007‐2011]/py 1,238 24 Feb 2011
#18. 'coronavirus'/de OR 'sars coronavirus'/de AND [embase]/lim AND [2007‐2011]/py 1,515 24 Feb 2011
#17. rhinovir*:ab,ti AND [embase]/lim AND [2007‐2011]/py 787 24 Feb 2011
#16. 'rhinovirus infection'/de OR 'human rhinovirus'/de AND [embase]/lim AND [2007‐2011]/py 389 24 Feb 2011
#15. sneez*:ab,ti OR rhinorrhea:ab,ti OR rhinorrhoea:ab,ti AND [embase]/lim AND [2007‐2011]/py 1,167 24 Feb 2011
#14. 'rhinorrhea'/de AND [embase]/lim AND [2007‐2011]/py 1,615 24 Feb 2011
#13. 'sneezing'/de AND [embase]/lim AND [2007‐2011]/py 999 24 Feb 2011
#12. ((nasal OR nose*) NEAR/2 (runny OR running OR congest* OR blocked OR discharg*)):ab,ti AND [2007‐2011]/py 1,001 24 Feb 2011
#11. 'nose obstruction'/de AND [embase]/lim 4,571 24 Feb 2011
#10. rhinitis:ab,ti OR nasopharyngitis:ab,ti OR rhinopharyngitis:ab,ti AND [embase]/lim 17,156 24 Feb 2011
#9. 'rhinitis'/de OR 'rhinopharyngitis'/de OR 'nose infection'/de AND [embase]/lim 13,616 24 Feb 2011
#8. epiglottitis:ab,ti AND [embase]/lim 944 24 Feb 2011
#7. 'epiglottitis'/exp AND [embase]/lim 1,349 24 Feb 2011
#6. uri:ab,ti OR urti:ab,ti AND [embase]/lim 879 24 Feb 2011
#5. 'upper respiratory tract infection':ab,ti OR 'upper respiratory tract infections':ab,ti OR 'upper respiratory infection':ab,ti OR 'upper respiratory infections':ab,ti AND [embase]/lim 4,873 24 Feb 2011
#4. 'upper respiratory tract infection'/de AND [embase]/lim 10,775 24 Feb 2011
#3. coryza:ab,ti AND [embase]/lim 196 24 Feb 2011
#2. 'common cold':ab,ti OR 'common colds':ab,ti AND [embase]/lim 2,062 24 Feb 2011
#1. 'common cold'/de AND [embase]/lim 3,684 24 Feb 2011
PRISMA flow chart.
'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
Comparison 1 Rhinovirus infection, Outcome 1 Number of patients with rhinovirus‐positive nasopharyngeal aspirates at day 7 of treatment.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Number of patients with rhinovirus‐positive nasopharyngeal aspirates at day 7 of treatment Show forest plot | 1 | 199 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.73, 1.34] |
