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Interventions for treating osteochondral defects of the talus in adults

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Appendices

Appendix 1. Search strategies

MEDLINE (Ovid interface)

1. randomized controlled trial.pt.
2. controlled clinical trial.pt.
3. randomized.ab.
4. placebo.ab.
5. clinical trials as topic.sh.
6. randomly.ab.
7. trial.ti.
8. 1 or 2 or 3 or 4 or 5 or 6 or 7
9. exp animals/ not humans/
10. 8 not 9
11. Talus/ or Ankle/
12. (talus or talar or ankle or talotibia$ or talo‐tibia$ or tibiotal$ or tibio‐tal$ or talocrural).mp.
13. 11 or 12
14. Cartilage, Articular/ or exp Osteochondritis/
15. (osteochond$ or cartilage).mp.
16. 15 or 14
17. 10 and 13 and 16 

EMBASE (Ovid interface)

1. Talus/ or Ankle/
2. (talus or talar or ankle or talocrural or talotibia$ or talo‐tibia$ or tibiotal$ or tibio‐tal$).mp.
3. 1 or 2
4. Articular Cartilage/ or Osteochondritis Dissecans/ or Osteochondritis/
5. (osteochond$ or cartilage).mp.
6. 4 or 5
7. Clinical trial/
8. Randomized controlled trial/
9. Randomization/
10. Single blind procedure/
11. Double blind procedure/
12. Crossover procedure/
13. Placebo/
14. randomi?ed controlled trial$.tw.
15. rct.tw.
16. random allocation.tw.
17. randomly allocated.tw.
18. allocated randomly.tw.
19. (allocated adj2 random).tw.
20. single blind$.tw.
21. double blind$.tw.
22. ((treble or triple) adj blind$).tw.
23. placebo$.tw.
24. Prospective study/
25. or/7‐24
26. Case study/
27. case report.tw.
28. Abstract report/ or letter/
29. or/26‐28
30. 25 not 29
31. limit 30 to human
32. 3 and 6 and 31

The Cochrane Central Register of Controlled Trials (Wiley InterScience interface)

1. MeSH descriptor Talus, this term only
2. MeSH descriptor Ankle, this term only
3. (talus or talar or ankle or talocrural or talotibia* or talo‐tibia* or tibiotal* or tibio‐tal*):ti,ab,kw
4. (1 or 2 or 3)
5. MeSH descriptor Cartilage, Articular, this term only

CINAHL (Ebsco interface)

1. (MH "Talus") or (MH "Ankle") or (MH "Ankle Joint")
2. TX (talus or talar or ankle or talocrural or talotibia* or talo‐tibia* or tibiotal* or tibio‐tal*)
3. 1 or 2
4. (MH "Cartilage, Articular") or (MH "Osteochondritis+")
5. TX (osteochond* or cartilage)
6. 4 or 5
7. (MH "Clinical Trials+")
8. (MH "Evaluation Research+")
9. (MH "Comparative Studies")
10. (MH "Crossover Design")
11. PT Clinical trial
12. 7 or 8 or 9 or 10 or 11
13. TX (clinical or controlled or comparative or placebo or prospective or randomised or randomized) and TX (trial or study)
14. TX random* and TX (allocat* or allot* or assign* or basis* or divid* or order*)
15. TX (singl* or doubl* or trebl* or tripl*) and TX (blind* or mask*)
16. TX crossover* or cross‐over or "cross over"
17. TX (allocat* or allot* or assign* or divid*) and TX (condition* or experiment* or intervention* or treatment* or therap* or control* or group*)
18. 13 or 14 or 15 or 16 or 17
19. 12 or 18
20. 3 and 6 and 19