Appendix 1. Medline search strategy

1   exp Ovarian Failure, Premature/
2   (ovar* and (failure or function or damage)).mp.
3   exp Fertility/
4   fertility.mp.
5   1 or 2 or 3 or 4
6   chemotherap*.mp.
7   (gonadal toxicity or gonadotoxic*).mp.
8   exp Antineoplastic Agents/
9   exp Antineoplastic Combined Chemotherapy Protocols/
10 6 or 7 or 8 or 9
11 exp Gonadotropin‐Releasing Hormone/
12 GnRH.mp.
13 gonadotropin‐releasing hormone.mp.
14 LHRH.mp.
15 luteinizing‐hormone releasing hormone.mp.
16 11 or 12 or 13 or 14 or 15
17 5 and 10 and 16
18 "randomized controlled trial".pt.
19 "controlled clinical trial".pt.
20 randomized.ab.
21 placebo.ab.
22 drug therapy.fs.
23 randomly.ab.
24 trial.ab.
25 groups.ab.
26 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25
27 17 and 26
28 Animals/
29 Humans/
30 28 not (28 and 29)
31 27 not 30

Key: mp=title, original title, abstract, name of substance word, subject heading word

        ab=abstract

        fs=floating subheading