Antibiotic versus placebo for meconium‐stained amniotic fluid in labour for preventing maternal and neonatal infections

Population: Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks
Settings: A hospital, North Carolina, United States
Intervention: Antibiotic versus placebo for preventing maternal and neonatal infections

Neonatal sepsis

RR 1
(0.21 to 4.76)

120
(1 study)

⊕⊕⊝⊝
low¹

Chorioamnionitis

RR 0.36
(0.21 to 0.62)

362
(2 studies)

⊕⊕⊕⊝
moderate²

Postpartum endometritis

RR 0.5
(0.18 to 1.38)

120
(1 study)

⊕⊕⊝⊝
low¹

Mortality and morbidity prior to discharge (Neonatal intensive care admissions)

RR 0.83
(0.39 to 1.78)

120
(1 study)

⊕⊕⊝⊝
low¹

Side effects of treatment

0 (0 study)

See comment

This outcome was not reported in any of the included studies.

Duration of admission to neonatal intensive care unit

0 (0 study)

See comment

This outcome was not reported in any of the included studies.

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk ratio;

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.