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Cochrane Database of Systematic Reviews

Tratamiento combinado con artemisinina para el paludismo no complicado

Información

DOI:
https://doi.org/10.1002/14651858.CD007483.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 08 julio 2009see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Enfermedades infecciosas

Clasificada:
  1. Actualización no planificada

    Review superseded

    Please refer to the Cochrane Special Collection: Sinclair 2014 https://doi.org/10.1002/14651858.SC000007/full

    Evaluada: 23 April 2019

Copyright:
  1. Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • David Sinclair

    Correspondencia a: International Health Group, Liverpool School of Tropical Medicine, Liverpool, UK

    [email protected]

  • Babalwa Zani

    South African Cochrane Centre, Medical Research Council, Cape Town, South Africa

  • Sarah Donegan

    International Health Group, Liverpool School of Tropical Medicine, Liverpool, UK

  • Piero Olliaro

    Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland

  • Paul Garner

    International Health Group, Liverpool School of Tropical Medicine, Liverpool, UK

Contributions of authors

All authors were involved in the conception and design of the protocol. Data extraction and assessment of risk of bias was performed by David Sinclair and Babalwa Zani. David Sinclair, Piero Olliaro, and Paul Garner worked on the analysis of secondary outcomes. Data input and analysis was conducted by David Sinclair with input from Piero Olliaro and Paul Garner and statistical advice from Sarah Donegan. The text was drafted by David Sinclair with input from all other authors.

Declarations of interest

None known.

Acknowledgements

This document is an output from a project funded by the UK Department for International Development (DFID) for the benefit of developing countries. We thank Hasifa Bukirwa for assistance with data extraction.

Version history

Published

Title

Stage

Authors

Version

2009 Jul 08

Artemisinin‐based combination therapy for treating uncomplicated malaria

Review

David Sinclair, Babalwa Zani, Sarah Donegan, Piero Olliaro, Paul Garner

https://doi.org/10.1002/14651858.CD007483.pub2

2008 Oct 08

Artemisinin‐based combination therapy for treating uncomplicated malaria

Protocol

David Sinclair, Babalwa Zani, Hasifa Bukirwa, Sarah Donegan, Piero Olliaro, Paul Garner

https://doi.org/10.1002/14651858.CD007483

Differences between protocol and review

Gametocyte clearance has been removed as a secondary outcome as the effect of ACTs on gametocytes is adequately assessed using the remaining two outcomes.

The multiple treatment comparison methodology as described under 'data synthesis' in the protocol was not used and this description has been removed.

The clinical questions posed under 'quality of evidence' were not stated in the protocol. These were added as currently relevant questions regarding the use of ACTs.

We did not use funnel plots to assess for publication bias as there were too few trials under each comparison for meaningful analysis.