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Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 1

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Comparison 1 Health status outcomes, Outcome 1 Pregnancy support.
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Analysis 1.1

Comparison 1 Health status outcomes, Outcome 1 Pregnancy support.

Comparison 1 Health status outcomes, Outcome 2 Pregnancy outcomes (dichotomous outcomes).
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Analysis 1.2

Comparison 1 Health status outcomes, Outcome 2 Pregnancy outcomes (dichotomous outcomes).

Comparison 1 Health status outcomes, Outcome 3 Pregnancy outcomes (continuous outcomes).
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Analysis 1.3

Comparison 1 Health status outcomes, Outcome 3 Pregnancy outcomes (continuous outcomes).

Comparison 2 Health behaviour outcomes, Outcome 1 Smoking cessation.
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Analysis 2.1

Comparison 2 Health behaviour outcomes, Outcome 1 Smoking cessation.

Comparison 2 Health behaviour outcomes, Outcome 2 Vitamin C: increased adherence (dichotomous).
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Analysis 2.2

Comparison 2 Health behaviour outcomes, Outcome 2 Vitamin C: increased adherence (dichotomous).

Comparison 2 Health behaviour outcomes, Outcome 3 Vitamin C: pills missed in the past week (continuous).
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Analysis 2.3

Comparison 2 Health behaviour outcomes, Outcome 3 Vitamin C: pills missed in the past week (continuous).

Comparison 2 Health behaviour outcomes, Outcome 4 Healthy behaviour in children.
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Analysis 2.4

Comparison 2 Health behaviour outcomes, Outcome 4 Healthy behaviour in children.

Comparison 3 User evaluation of intervention, Outcome 1 Acceptability.
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Analysis 3.1

Comparison 3 User evaluation of intervention, Outcome 1 Acceptability.

Comparison 4 Adverse outcomes of intervention, Outcome 1 Adverse outcomes.
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Analysis 4.1

Comparison 4 Adverse outcomes of intervention, Outcome 1 Adverse outcomes.

Summary of findings for the main comparison. Effect of mobile phone messaging interventions for preventive health care

Patient or population: Various (pregnant women; daily smokers aged 16 and older; university students; children aged 5‐13)

Settings: Various (antenatal clinics and postpartum wards in Thailand; outpatient settings in New Zealand, Canada and the USA)

Intervention: Information and support for healthy behaviours delivered by mobile phone messaging

Control: Usual care

Outcomes

Impact

No of Participants
(studies)

Quality of the evidence
(GRADE)

Health outcomes

Satisfaction, anxiety and confidence during pregnancy

Women who received mobile phone messages with information relating to abnormal symptoms during pregnancy showed significantly higher satisfaction scores in the antenatal and perinatal period. In the antenatal period their confidence level was also higher and their anxiety level lower, although in the perinatal period these differences were no longer statistically significant.

61
(1 study)

⊕⊕⊕⊝
moderate1

Pregnancy outcomes

Mobile phone messages with information relating to abnormal symptoms during pregnancy had no statistically significant impacts on gestational age at birth, infant birth weight, frequency of preterm delivery or route of delivery.

61
(1 study)

⊕⊕⊝⊝
low1,2

Health behaviour outcomes

Smoking cessation

Mobile phone messaging support for smoking cessation resulted in a significant increase of quit rates at 6 weeks (RR 2.20, 95% CI 1.79 to 2.70) and 12 weeks follow‐up (RR 1.55, 95% CI 1.30 to 1.84). The effect persisted at 26 weeks if last values were carried forward (RR 1.28, 95% CI 1.11 to 1.48). Continuous abstinence at 26 weeks, allowing three or fewer ‘lapses’ of two or fewer cigarettes per lapse, was also higher in the intervention group (RR 1.64, 95% CI 1.12 to 2.42), whereas there was no impact on continuous complete abstinence (RR 1.4, 95% CI 0.92 to 2.44).

1705
(1 study)

⊕⊕⊕⊕
high

Vitamin C adherence

Participants receiving mobile phone messaging reminders to take vitamin C tablets for preventive reasons showed significantly higher self‐reported adherence, and a marginal reduction in the number of missed tablets in the last 7 days compared to those who did not receive any reminders (MD ‐0.80, 95% CI ‐1.55 to ‐0.05).

99
(1 study)

⊕⊕⊕⊝
moderate1

Healthy behaviour in children

Tracking of healthy behaviours in children using mobile phone messages did not result in any significant differences on their level of physical activity, consumption of sugar‐sweetened beverages or screen time, compared to tracking using a paper diary or no tracking at all.

32
(1 study)

⊕⊝⊝⊝
very low1,3

User evaluation of the intervention

Acceptability

Children and their parents who used mobile phone messaging to track healthy behaviours in children reported no differences in acceptability of the intervention compared to groups using either paper diary reporting or no tracking.

32
(1 study)

⊕⊝⊝⊝
very low1,3

Adverse effects of the intervention

Adverse effects

A mobile phone messaging intervention to support smoking cessation did not have any significant impact on the rates of pain in the thumb or finger joints (RR 1.08, 95% CI 0.74 to 1.59), or on car crash rates (RR 0.88, 95% CI 0.58 to 1.35) at 26 weeks of follow‐up.

1705
(1 study)

⊕⊕⊕⊝
moderate4

Other outcomes

Health service utilisation

None of the included studies report on the impact of the intervention on health services utilisation

Cost

None of the included studies report on the cost or cost‐effectiveness of the intervention

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Low number of participants.

2 It is unlikely that the intervention would impact pregnancy outcomes such as gestational age, birth weight or duration of gestation. Although it is similarly unlikely that the intervention would directly impact emergency cesarean section rates, it is feasible that prenatal support would influence women's decision for mode of delivery.

3 Moderate risk of bias.

4 Very low number of adverse events reported in both groups.

Figuras y tablas -
Summary of findings for the main comparison. Effect of mobile phone messaging interventions for preventive health care
Comparison 1. Health status outcomes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pregnancy support Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

1.1 Satisfaction during pregnancy

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

1.2 Confidence during pregnancy

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

1.3 Less anxiety during pregnancy

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2 Pregnancy outcomes (dichotomous outcomes) Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only

2.1 Preterm delivery

1

61

Risk Ratio (M‐H, Random, 95% CI)

0.18 [0.01, 3.64]

2.2 Cesarean section delivery

1

61

Risk Ratio (M‐H, Random, 95% CI)

1.09 [0.37, 3.19]

3 Pregnancy outcomes (continuous outcomes) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Subtotals only

3.1 Birth weight (gm)

1

61

Mean Difference (IV, Random, 95% CI)

‐137.0 [‐412.87, 138.87]

3.2 Gestational age in delivery (weeks)

1

61

Mean Difference (IV, Random, 95% CI)

0.10 [‐0.45, 0.65]

Figuras y tablas -
Comparison 1. Health status outcomes
Comparison 2. Health behaviour outcomes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Smoking cessation Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only

1.1 No smoking in the past week at 6 wk follow‐up

1

1705

Risk Ratio (M‐H, Random, 95% CI)

2.20 [1.79, 2.70]

1.2 No smoking in the past week at 12 wk follow‐up

1

1705

Risk Ratio (M‐H, Random, 95% CI)

1.55 [1.30, 1.84]

1.3 No smoking in the past week at 26 wk follow‐up

1

1705

Risk Ratio (M‐H, Random, 95% CI)

1.07 [0.91, 1.26]

1.4 No smoking in the past week at 26 wk follow‐up (LVCF)

1

1705

Risk Ratio (M‐H, Random, 95% CI)

1.28 [1.11, 1.48]

1.5 Number abstaining (with < 3 lapses of 2 or fewer cigarettes)

1

1705

Risk Ratio (M‐H, Random, 95% CI)

1.64 [1.12, 2.42]

1.6 Number abstaining completely

1

1705

Risk Ratio (M‐H, Random, 95% CI)

1.50 [0.92, 2.44]

2 Vitamin C: increased adherence (dichotomous) Show forest plot

1

99

Risk Ratio (M‐H, Random, 95% CI)

1.41 [1.14, 1.74]

3 Vitamin C: pills missed in the past week (continuous) Show forest plot

1

99

Mean Difference (IV, Random, 95% CI)

‐0.80 [‐1.55, ‐0.05]

4 Healthy behaviour in children Show forest plot

1

Std. Mean Difference (IV, Random, 95% CI)

Totals not selected

4.1 Exercise

1

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4.2 Sugar‐sweetened beverage servings

1

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4.3 Screen time

1

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

Figuras y tablas -
Comparison 2. Health behaviour outcomes
Comparison 3. User evaluation of intervention

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Acceptability Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Subtotals only

1.1 Parent (SMS vs PD)

1

63

Mean Difference (IV, Random, 95% CI)

‐0.00 [‐1.08, 1.08]

1.2 Child (SMS vs PD)

1

63

Mean Difference (IV, Random, 95% CI)

0.15 [‐0.32, 0.62]

1.3 Parent (SMS vs C)

1

72

Mean Difference (IV, Random, 95% CI)

‐0.45 [‐1.84, 0.94]

1.4 Child (SMS vs C)

1

72

Mean Difference (IV, Random, 95% CI)

0.46 [‐0.07, 1.00]

Figuras y tablas -
Comparison 3. User evaluation of intervention
Comparison 4. Adverse outcomes of intervention

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Adverse outcomes Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only

Figuras y tablas -
Comparison 4. Adverse outcomes of intervention