Appendix 1. CENTRAL search strategy

#1 MeSH descriptor Toxoplasmosis, Ocular
#2 MeSH descriptor Toxoplasmosis, Congenital
#3 MeSH descriptor Chorioretinitis
#4 (#1 OR #2 OR #3)
#5 toxoplasm*
#6 ocular or retinochoroiditi* or choroidoretiniti* or choroiditi* or T gondi or T gondii or retino‐choroiditi* or chorioretinal* or neuroretiniti* or chorioretiniti* or pars‐planiti* or scleriti* or papilliti* or uveiti* or iridocycliti* or vitriti*
#7 (#5 AND #6)
#8 (#5 OR #7)
#9 MeSH descriptor Adrenal Cortex Hormones
#10 MeSH descriptor Glucocorticoids
#11 *steroid*
#12 *corticoid*
#13 MeSH descriptor Prednisolone
#14 MeSH descriptor Prednisone
#15 prednisolone or prednisone
#16 (#9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15)
#17 (#8 AND #16)

Appendix 2. MEDLINE search strategy

1. randomized controlled trial.pt.
2. (randomized or randomised).ab,ti.
3. placebo.ab,ti.
4. dt.fs.
5. randomly.ab,ti.
6. trial.ab,ti.
7. groups.ab,ti.
8. or/1‐7
9. exp animals/
10. exp humans/
11. 9 not (9 and 10)
12. 8 not 11
13. exp Toxoplasmosis, Ocular/
14. exp Toxoplasmosis, Congenital/
15. exp chorioretinitis/
16. or/13‐15
17. toxoplasm$.tw.
18. (ocular or retinochoroiditi$ or choroidoretiniti$ or choroiditi$ or T gondi or T gondii or retino‐choroiditi$ or chorioretinal$ or neuroretiniti$ or chorioretiniti$ or pars‐planiti$ or scleriti$ or papilliti$ or uveiti$ or iridocycliti$ or vitriti$).tw.
19. 17 and 18
20. 16 or 19
21. exp corticosteroids/
22. exp glucocorticoids/
23. ?steroid$.tw.
24. ?corticoid$.tw.
25. exp prednisolone/
26. exp prednisone/
27. (prednisolone or prednisone).tw.
28. or/21‐27
29. 20 and 28

The search filter for trials at the beginning of the MEDLINE strategy is from the published paper by Glanville et al (Glanville 2006).

Appendix 3. EMBASE search strategy

1. exp randomized controlled trial/
2. exp randomization/
3. exp double blind procedure/
4. exp single blind procedure/
5. random$.tw.
6. or/1‐5
7. (animal or animal experiment).sh.
8. human.sh.
9. 7 and 8
10. 7 not 9
11. 6 not 10
12. exp clinical trial/
13. (clin$ adj3 trial$).tw.
14. ((singl$ or doubl$ or trebl$ or tripl$) adj3 (blind$ or mask$)).tw.
15. exp placebo/
16. placebo$.tw.
17. random$.tw.
18. exp experimental design/
19. exp crossover procedure/
20. exp control group/
21. exp latin square design/
22. or/12‐21
23. 22 not 10
24. 23 not 11
25. exp comparative study/
26. exp evaluation/
27. exp prospective study/
28. (control$ or prospectiv$ or volunteer$).tw.
29. or/25‐28
30. 29 not 10
31. 30 not (11 or 23)
32. 11 or 24 or 31
33. exp Toxoplasmosis/
34. exp Congenital Toxoplasmosis/
35. or/33‐34
36. toxoplasm$.tw.
37. (ocular or retinochoroiditi$ or choroidoretiniti$ or choroiditi$ or T gondi or T gondii or retino‐choroiditi$ or chorioretinal$ or neuroretiniti$ or chorioretiniti$ or pars‐planiti$ or scleriti$ or papilliti$ or uveiti$ or iridocycliti$ or vitriti$).tw.
38. 36 and 37
39. 35 or 38
40. exp corticosteroid/
41. exp glucocorticoids/
42. ?steroid$.tw.
43. ?corticoid$.tw.
44. exp prednisolone/
45. exp prednisolone acetate/
46. exp prednisone/
47. exp prednisone acetate/
48. (prednisolone or prednisone).tw.
49. or/40‐48
50. 39 and 49
51. 32 and 50

Appendix 4. LILACS search strategy

toxoplasm$ and ocular or retinochoroiditi$ or choroidoretiniti$ or choroiditi$ or T gondi or T gondii or retino‐choroiditi$ or chorioretinal$ or neuroretiniti$ or chorioretiniti$ or pars‐planiti$ or scleriti$ or papilliti$ or uveiti$ or iridocycliti$ or vitriti$ and steroid$ or cocorticoid$ or prednisolone or prednisone

Appendix 5. UK Clinical Trials Gateway search strategy

(steroid* or corticoid*) AND toxoplasm*