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Percent of participants with at least 50% pain relief over 4 to 6 hours. Size of circle is proportional to size of study (inset scale). Dental studies: yellow. Bunionectomy study: dark blue. Other non‐dental studies: light blue.
Figuras y tablas -
Figure 1

Percent of participants with at least 50% pain relief over 4 to 6 hours. Size of circle is proportional to size of study (inset scale). Dental studies: yellow. Bunionectomy study: dark blue. Other non‐dental studies: light blue.

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Forest plot of comparison: 3 Ketoprofen 50 mg versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Figure 2

Forest plot of comparison: 3 Ketoprofen 50 mg versus placebo, outcome: 3.1 Participants with at least 50% pain relief over 4 to 6 hours.

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Forest plot of comparison: 6 Dexketoprofen 20/25 mg versus placebo, outcome: 6.1 Participants with at least 50% pain relief over 4 to 6 hours.
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Figure 3

Forest plot of comparison: 6 Dexketoprofen 20/25 mg versus placebo, outcome: 6.1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 1 Ketoprofen 12.5 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
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Analysis 1.1

Comparison 1 Ketoprofen 12.5 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 1 Ketoprofen 12.5 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.
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Analysis 1.2

Comparison 1 Ketoprofen 12.5 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.

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Comparison 1 Ketoprofen 12.5 mg versus placebo, Outcome 3 Participants with any adverse event.
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Analysis 1.3

Comparison 1 Ketoprofen 12.5 mg versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 2 Ketoprofen 25 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 2.1

Comparison 2 Ketoprofen 25 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 2 Ketoprofen 25 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.
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Analysis 2.2

Comparison 2 Ketoprofen 25 mg versus placebo, Outcome 2 Participants using rescue medication over 6 hours.

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Comparison 2 Ketoprofen 25 mg versus placebo, Outcome 3 Participants with any adverse event.
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Analysis 2.3

Comparison 2 Ketoprofen 25 mg versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 3 Ketoprofen 50 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
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Analysis 3.1

Comparison 3 Ketoprofen 50 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 3 Ketoprofen 50 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.
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Analysis 3.2

Comparison 3 Ketoprofen 50 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.

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Comparison 3 Ketoprofen 50 mg versus placebo, Outcome 3 Participants with any adverse event.
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Analysis 3.3

Comparison 3 Ketoprofen 50 mg versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 4 Ketoprofen 100 mg versus placebo, Outcome 1 Patients with at least 50% pain relief.
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Analysis 4.1

Comparison 4 Ketoprofen 100 mg versus placebo, Outcome 1 Patients with at least 50% pain relief.

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Comparison 4 Ketoprofen 100 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.
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Analysis 4.2

Comparison 4 Ketoprofen 100 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.

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Comparison 4 Ketoprofen 100 mg versus placebo, Outcome 3 Participants with any adverse event.
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Analysis 4.3

Comparison 4 Ketoprofen 100 mg versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 5 Dexketoprofen 10/12.5 mg versus placebo, Outcome 1 Patients with at least 50% pain relief.
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Analysis 5.1

Comparison 5 Dexketoprofen 10/12.5 mg versus placebo, Outcome 1 Patients with at least 50% pain relief.

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Comparison 5 Dexketoprofen 10/12.5 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.
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Analysis 5.2

Comparison 5 Dexketoprofen 10/12.5 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.

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Comparison 5 Dexketoprofen 10/12.5 mg versus placebo, Outcome 3 Participants with any adverse event.
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Analysis 5.3

Comparison 5 Dexketoprofen 10/12.5 mg versus placebo, Outcome 3 Participants with any adverse event.

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Comparison 6 Dexketoprofen 20/25 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
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Analysis 6.1

Comparison 6 Dexketoprofen 20/25 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 6 Dexketoprofen 20/25 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.
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Analysis 6.2

Comparison 6 Dexketoprofen 20/25 mg versus placebo, Outcome 2 Participants using rescue medication over 6 to 8 hours.

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Comparison 6 Dexketoprofen 20/25 mg versus placebo, Outcome 3 Participants with any adverse event.
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Analysis 6.3

Comparison 6 Dexketoprofen 20/25 mg versus placebo, Outcome 3 Participants with any adverse event.

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Table 1. Summary of outcomes: analgesia and use of rescue medication

Analgesia

Rescue medication

Study ID

Treatment

PI or PR

Number with 50% PR

PGE: v good or excellent

Median time to use (hr)

% using

Arnold 1990

(1) ketoprofen 25 mg, n = 14

(2) Ketoprofen 100 mg, n = 16

(3) Ibuprofen 400 mg, n = 15

(4) Placebo, n = 14

TOTPAR 6:

(1) 6.0

(2) 9.8

(4) 1.5

(1) 3/14

(2) 7/16

(4) 0/14

at 6 h:

(1) 2/14

(2) 7/16

(4) 1/14

Mean:

(1) 4.8

(2) 4.4

(4) 2.4

at 6 h:

(1) 46

(2) 45

(4) 83

Cooper 1984

(1) Ketoprofen 25 mg, n = 30

(2) Ketoprofen 50 mg, n = 31

(3) Ketoprofen 100 mg, n = 31

(4) Aspirin 650 mg, n = 31

(5) Placebo, n = 31

TOTPAR 6:

(1) 13.6

(2) 15.5

(3) 17.1

(5) 4.63

(1) 18/30

(2) 23/31

(3) 26/31

(5) 4/31

No usable data

Mean:

(1) 4.8

(2) 4.8

(3) 4.9

(5) 2.6

No data

Cooper 1988

(1) Ketoprofen 25 mg, n = 42

(2) Ketoprofen 100 mg, n = 39

(3) Ibuprofen 400 mg, n = 37

(4) Placebo, n = 43

TOTPAR 6:

(1) 12.0

(2) 15.2

(4) 4.7

(1) 23/42

(2) 28/39

(4) 6/43

at 6 h:

(1) 17/42

(2) 21/39

(4) 2/43

Mean:

(1) 5.0

(2) 4.3

(4) 3.0

at 6 h:

(1) 69

(2) 36

(4) 79

Cooper 1998

(1) Dexketoprofen 25 mg, n = 50

(2) Dexketoprofen 100 mg, n = 51

(3) Paracetamol 1000 mg, n =50

(4) Placebo, n = 26

TOTPAR 6:

(1) 5.3

(2) 8.2

(4) 4.5

(1) 9/50

(2) 17/51

(4) 0/26

No data

(1) 2.1

(2) 3.3

(4) 1.7

at 6 h:

(1) 76

(2) 57

(4) 78

Gay 1996

(1) Dexketoprofen 5 mg, n = 41

(2) Dexketoprofen 10 mg, n = 42

(3) Dexketoprofen 20 mg, n = 41

(4) Ibuprofen 400 mg, n = 41

(5) Placebo, n = 41

TOTPAR 6:

(1) 9.8

(2) 10.5

(3) 11.3

(5) 5.2

(1) 18/41

(2) 20/42

(3) 24/41

(5) 7/39

No usable data

Mean:

(1) 5.0

(2) 4.82

(3) 5.0

(5) 3.65

at 6 h:

(1) 34

(2) 48

(3) 43

(5) 67

Harrison 1996

(1) Dexketoprofen 12.5 mg, n = 49

(2) Dexketoprofen 25 mg, n = 46

(3) Placebo, n = 46

TOTPAR 6:

(1) 10.6

(2) 12.4

(3) 5.2

(1) 23/48

(2) 26/45

(3) 8/44

No usable data

No data

at 6 h:

(1) 33

(2) 20

(3) 48

Jackson 2004

(1) Dexketoprofen 25 mg, n = 42

(2) Rofecoxib 50 mg, n = 38

(3) Placebo, n = 43

No usable data

No usable data

(1) 6.6

(3) 2.5

at 24 h:

(1) 83

(3) 88

McGurk 1998

(1) Ketoprofen 50 mg, n = 43

(2) Dexketopfofen 12.5 mg, n = 44

(3) Dexketopfofen 25 mg, n = 41

(4) Dexketopfofen 50 mg, n = 43

(5) Placebo, n = 39

TOTPAR 6:

(1) 10.2

(2) 12.6

(3) 12.3

(4) 12.2

(5) 3.2

(1) 22/40

(2) 18/41

(3) 23/40

(4) 24/42

(5) 2/37

No usable data

Mean:

(1) 5.5

(2) 4.9

(3) 5.3

(4) 5.4

(5) 3.6

at 6 h:

(1) 15

(2) 41

(3) 27

(4) 24

(5) 71

Mehlisch 1984

(1) Ketoprofen 25 mg, n = 24

(2) Ketoprofen 50 mg, n = 27

(3) Ketoprofen 100 mg, n = 27

(4) Codeine 90 mg, n = 27

(5) Placebo, n = 24

TOTPAR 6:

(1) 12.4

(2) 12.7

(3) 12.8

(5) 1.8

(1) 14/24

(2) 16/27

(3) 16/27

(4) 0/24

No usable data

No data

at 6 h:

(1) 54

(2) 72

(3) 51

(4) 96

Olson 1999

(1) Ketoprofen (liquid) 25 mg, n = 28

(2) Ketoprofen (liquid) 50 mg, n = 26

(3) Dipyrone (liquid) 500 mg, n = 27

(3) Placebo, n = 27

TOTPAR 6:

(1) 14.3

(2) 14.3

(4) 4.8

(1) 19/28

(2) 18/26

(4) 5/27

No data

Mean:

(1) >6

(2) 5.9

(3) 5.3

at 6 h:

(1) 0

(2) 4

(4) 33

Olson 2001

(1) Ketoprofen 25 mg, n = 67

(2) Ibuprofen liquigel 400 mg, n = 67

(3) Paracetamol 1000 mg, n = 66

(4) Placebo, n = 39

TOTPAR 6:

(1) 15.0

(4) 4.3

(1) 48/67

(4) 5/39

(1) 47/67

(4) 4/39

(1) >6

(4) 1.3

at 6 h:

(1) 20/67

(4) 31/39

Schreiber 1996

(1) Ketoprofen 50 mg, n = 54

(2) Dexketoprofen 12.5 mg, n = 52

(3) Dexketoprofen 25 mg, n = 52

(4) Placebo, n = 55

TOTPAR 4:

(1) 6.8

(2) 8.0

(3) 9.0

(4) 5.8

(1) 24/54

(2) 29/52

(3) 33/52

(4) 20/55

No usable data

No data

at 8 h:

(1) 31

(2) 27

(3) 23

(4) 55

Seymour 1996

(1) Ketoprofen 12.5mg, n = 42

(2) Ketoprofen 25 mg, n = 41

(3) Paracetamol 500 mg, n = 41

(4) Paracetamol 1000 mg, n = 41

(5) Placebo, n = 41

No usable data

at 6 h:

(1) 28/42

(2) 28/41

(5) 8/41

(1) 4.0

(2) 4.1

(5) 1.8

at 6 h:

(1) 75

(2) 76

(5) 97

Seymour 2000

(1) Buffered ketoprofen 12.5 mg, n = 61

(2) Ibuprofen 200 mg, n = 59

(3) Placebo, n = 60

TOTPAR 6:

(1) 9.8

(3) 4.1

(1) 26/61

(3) 7/60

No usable data

(1) 2.7

(3) 1.9

at 6 h:

(1) 87

(3) 98

Sunshine 1993

(1) Ketoprofen 50 mg, n = 48

(2) Ketoprofen 100 mg, n = 48

(3) Paracetamol 650 mg, n = 48

(4) Paracetamol + oxycodone 650/10 mg, n = 48

(5) Placebo, n = 48

TOTPAR 6:

(1) 11.3

(2) 12.9

(5) 8.8

(1) 25/48

(2) 29/48

(5) 18/48

No usable data

(1) 7.0

(2) 8.8

(5) 6.0

at 8 h:

(1) 69

(2) 46

(5) 73

Sunshine 1998

(1) Ketoprofen 6.25 mg, n = 35

(2) Ketoprofen 12.5 mg, n = 35

(3) Ketoprofen 25 mg, n = 35

(4) Ibuprofen 200 mg, n = 35

(5) Placebo, n = 35

TOTPAR 6:

(1) 7.2

(2) 13.7

(3) 13.0

(5) 3.6

(1) 10/35

(2) 23/35

(3) 21/35

(5) 3/35

No usable data

No usable data

No usable data

Turek 1988

(1) Ketoprofen 50 mg, n = 41

(2) Ketoprofen 150 mg, n = 39

(3) Paracetamol + codeine 650/60 mg, n = 39

(4) Placebo, n = 42

TOTPAR 6:

(1) 11.4

(2) 12.2

(4) 4.6

(1) 21/41

(2) 22/39

(4) 6/41

No usable data

Mean:

(1) 2.3

(2) 3.2

(4) 2.2

at 6 h:

(1) 41

(2) 46

(4) 83

Vidal 1999

(1) Ketoprofen 50 mg, n = 47

(2) Dexketoprofen 12.5 mg, n = 47

(3) Dexketoprofen 25 mg, n = 47

(4) Placebo, n = 47

TOTPAR 6:

(1) 2.7

(2) 7.4

(3) 7.4

(4) 2.5

(1) 2/47

(2) 14/47

(3) 14/47

(4) 1/47

No usable data

Mean:

(1) 1.76

(2) 2.31

(3) 2.2

(4) 1.68

at 6 h:

(1) 98

(2) 91

(3) 93

(4) 100
Figuras y tablas -
Table 1. Summary of outcomes: analgesia and use of rescue medication
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Table 2. Summary of outcomes: adverse events and withdrawals

Adverse events

Withdrawals

Study ID

Treatment

Any

Serious

Adverse event

Other

Arnold 1990

(1) ketoprofen 25 mg, n = 14

(2) Ketoprofen 100 mg, n = 16

(3) Ibuprofen 400 mg, n = 15

(4) Placebo, n = 14

at 6 h:

(1) 3/14

(2) 6/16

(4) 3/14

None

(1) 1/14 (nausea and dizziness after 1 h)

None reported

Cooper 1984

(1) Ketoprofen 25 mg, n = 30

(2) Ketoprofen 50 mg, n = 31

(3) Ketoprofen 100 mg, n = 31

(4) Aspirin 650 mg, n = 31

(5) Placebo, n = 31

at 6 h:

(1) 7/30

(2) 10/31

(3) 9/31

(5) 6/30

None

None

Exclusions due to not taking medication, protocol violations and loss to follow up:

(1) 6, (2) 5, (3) 5, (4) 6, (5) 6

Cooper 1988

(1) Ketoprofen 25 mg, n = 42

(2) Ketoprofen 100 mg, n = 39

(3) Ibuprofen 400 mg, n = 37

(4) Placebo, n = 43

at 6 h:

(1) 8/44

(2) 4/39

(4) 7/45

None reported

None reported

20 exclusions: 13 lost to follow up and 7 protocol violations

Cooper 1998

(1) Dexketoprofen 25 mg, n = 50

(2) Dexketoprofen 100 mg, n = 51

(3) Paracetamol 1000 mg, n = 50

(4) Placebo, n = 26

at 6 h:

(1) 22/50

(2) 16/51

(4) 4/26

None

None

None

Gay 1996

(1) Dexketoprofen 5 mg, n = 41

(2) Dexketoprofen 10 mg, n = 42

(3) Dexketoprofen 20 mg, n = 41

(4) Ibuprofen 400 mg, n = 41

(5) Placebo, n = 41

at 6 h:

(1) 3/41

(2) 2/42

(3) 5/41

(5) 4/39

None

None

2 exclusions in placebo group due to early remedication

Harrison 1996

(1) Dexketoprofen 12.5 mg, n = 49

(2) Dexketoprofen 25 mg, n = 46

(3) Placebo, n = 46

at 6 h:

(1) 6/49

(2) 7/46

(3) 6/46

None

(1) 0/49

(2) 1/46

(3) 1/46

6 exclusions due to protocol violations.

Jackson 2004

(1) Dexketoprofen 25 mg, n = 42

(2) Rofecoxib 50 mg, n = 38

(3) Placebo, n = 43

at 24 h:

(1) 5/42

(3) 4/41

None

None

3 participants excluded from analyses: 2 in placebo group lost to follow up, 1 in rofecoxib group did not take medication

McGurk 1998

(1) Ketoprofen 50 mg, n = 43

(2) Dexketopfofen 12.5 mg, n = 44

(3) Dexketopfofen 25 mg, n = 41

(4) Dexketopfofen 50 mg, n = 43

(5) Placebo, n = 39

at 6 h:

(1) 5/43

(2) 4/41

(3) 4/41

(4) 7/43

(5) 8/39

None

(1) 0/42

(2) 0/44

(3) 0/41

(4) 1/43

(5) 1/39

10 participants excluded from efficacy analyses due to early remedication or loss to follow up:

(1) 3, (2) 3, (3) 1, (4) 1, (5) 2

Mehlisch 1984

(1) Ketoprofen 25 mg, n = 24

(2) Ketoprofen 50 mg, n = 27

(3) Ketoprofen 100 mg, n = 27

(4) Codeine 90 mg, n = 27

(5) Placebo, n = 24

at 6 h:

54 participants in total

None reported

None reported

9 participants received medication but were not included in analysis. Reasons and groups not given.

Olson 1999

(1) Ketoprofen liquid 25 mg, n = 28

(2) Ketoprofen liquid 50 mg, n = 26

(3) Dipyrone liquid 500 mg, n = 27

(3) Placebo, n = 27

No adverse events reported

None

None

None

Olson 2001

(1) Ketoprofen 25 mg, n = 67

(2) Ibuprofen liquigel 400 mg, n = 67

(3) Paracetamol 1000 mg, n = 66

(4) Placebo, n = 39

at 6 h:

(1) 5/67

(4) 2/39

None

None

None

Schreiber 1996

(1) Ketoprofen 50 mg, n = 54

(2) Dexketoprofen 12.5 mg, n = 52

(3) Dexketoprofen 25 mg, n = 52

(4) Placebo, n = 55

No single dose data

None

Multiple dose :

(1) 0/54

(2) 1/52

(3) 2/52

(4) 1/55

Multiple dose (includes successful therapy) :

(1) 35/54

(2) 36/52

(3) 35/52

(4) 39/55

Seymour 1996

(1) Ketoprofen 12.5mg, n = 42

(2) Ketoprofen 25 mg, n = 41

(3) Paracetamol 500 mg, n = 41

(4) Paracetamol 1000 mg, n = 41

(5) Placebo, n = 41

at 6 h:

(1) 0/42

(2) 0/41

(5) 0/41

None

None

Excusions due to early remedication:

(1) 2, (3) 1, (4) 1, (5) 2

Seymour 2000

(1) Buffered ketoprofen 12.5 mg, n = 61

(2) Ibu 200 mg, n = 59

(3) Placebo, n = 60

at 6 h:

(1) 2/61

(3) 3/60

None

None

Exclusions due to protocol violations:

(2) 1, (3) 1

Sunshine 1993

(1) Ketoprofen 50 mg, n = 48

(2) Ketoprofen 100 mg, n = 48

(3) Paracetamol 650 mg, n = 48

(4) Paracetamol + oxycodone 650/10 mg, n = 48

(5) Placebo, n = 48

No single dose data

"No cases of possible clinical concern" (multiple dose included)

None

None

Sunshine 1998

(1) Ketoprofen 6.25 mg, n = 35

(2) Ketoprofen 12.5 mg, n = 35

(3) Ketoprofen 25 mg, n = 35

(4) Ibuprofen 200 mg, n = 35

(5) Placebo, n = 35

at 6 h:

(1) 3/35

(2) 6/35

(3) 3/35

(5) 3/35

None

None

Exclusions due to early remedication, protocol violation:

(2) 1, (3) 1, (5) 2

Turek 1988

(1) Ketoprofen 50 mg, n = 41

(2) Ketoprofen 150 mg, n = 39

(3) Paracetamol + codeine 650/60 mg, n = 39

(5) Placebo, n = 42

at 6 h:

(1) 14/41

(2) 8/39

(3) 4/41

None

None

1 exclusion in placebo group due to protocol violation.

Vidal 1999

(1) Ketoprofen 50 mg, n = 47

(2) Dexketoprofen 12.5 mg, n = 47

(3) Dexketoprofen 25 mg, n = 47

(3) Placebo, n = 47

No single dose data

None

Multiple dose:

(1) 0/43

(2) 1/45

(3) 1/41

(4) 2/43

Multiple dose :

(1) 0/43

(2) 2/45

(3) 2/41

(4) 3/43
Figuras y tablas -
Table 2. Summary of outcomes: adverse events and withdrawals
Ir a la tabla de la revisión
Comparison 1. Ketoprofen 12.5 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

3

274

Risk Ratio (M‐H, Fixed, 95% CI)

4.21 [2.68, 6.63]

2 Participants using rescue medication over 6 hours Show forest plot

2

198

Risk Ratio (M‐H, Fixed, 95% CI)

0.81 [0.74, 0.90]

3 Participants with any adverse event Show forest plot

3

274

Risk Ratio (M‐H, Fixed, 95% CI)

1.33 [0.48, 3.64]
Figuras y tablas -
Comparison 1. Ketoprofen 12.5 mg versus placebo
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Comparison 2. Ketoprofen 25 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

8

535

Risk Ratio (M‐H, Fixed, 95% CI)

4.88 [3.48, 6.85]

1.1 Dental surgery

6

452

Risk Ratio (M‐H, Fixed, 95% CI)

5.07 [3.50, 7.36]

1.2 Other surgery

2

83

Risk Ratio (M‐H, Fixed, 95% CI)

3.96 [1.77, 8.86]

2 Participants using rescue medication over 6 hours Show forest plot

6

402

Risk Ratio (M‐H, Fixed, 95% CI)

0.60 [0.52, 0.69]

3 Participants with any adverse event Show forest plot

7

490

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.68, 1.96]
Figuras y tablas -
Comparison 2. Ketoprofen 25 mg versus placebo
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Comparison 3. Ketoprofen 50 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

8

624

Risk Ratio (M‐H, Fixed, 95% CI)

2.67 [2.06, 3.46]

1.1 Dental surgery

3

190

Risk Ratio (M‐H, Fixed, 95% CI)

9.04 [4.23, 19.30]

1.2 Other surgery

5

434

Risk Ratio (M‐H, Fixed, 95% CI)

1.82 [1.38, 2.41]

2 Participants using rescue medication over 6 to 8 hours Show forest plot

7

554

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.57, 0.73]

2.1 6 hours

5

349

Risk Ratio (M‐H, Fixed, 95% CI)

0.59 [0.51, 0.68]

2.2 8 hours

2

205

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.61, 0.98]

3 Participants with any adverse event Show forest plot

4

278

Risk Ratio (M‐H, Fixed, 95% CI)

1.55 [0.91, 2.62]
Figuras y tablas -
Comparison 3. Ketoprofen 50 mg versus placebo
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Comparison 4. Ketoprofen 100 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Patients with at least 50% pain relief Show forest plot

5

321

Risk Ratio (M‐H, Fixed, 95% CI)

3.72 [2.62, 5.28]

1.1 Dental surgery

3

195

Risk Ratio (M‐H, Fixed, 95% CI)

6.93 [3.85, 12.48]

1.2 Other surgery

2

126

Risk Ratio (M‐H, Fixed, 95% CI)

1.94 [1.26, 3.00]

2 Participants using rescue medication over 6 to 8 hours Show forest plot

4

259

Risk Ratio (M‐H, Fixed, 95% CI)

0.54 [0.44, 0.67]

2.1 6 hours

3

163

Risk Ratio (M‐H, Fixed, 95% CI)

0.49 [0.38, 0.65]

2.2 8 hours

1

96

Risk Ratio (M‐H, Fixed, 95% CI)

0.63 [0.44, 0.89]

3 Participants with any adverse event Show forest plot

3

175

Risk Ratio (M‐H, Fixed, 95% CI)

1.19 [0.65, 2.16]
Figuras y tablas -
Comparison 4. Ketoprofen 100 mg versus placebo
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Comparison 5. Dexketoprofen 10/12.5 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Patients with at least 50% pain relief Show forest plot

5

452

Risk Ratio (M‐H, Fixed, 95% CI)

2.68 [1.95, 3.68]

1.1 Dental surgery

3

251

Risk Ratio (M‐H, Fixed, 95% CI)

3.29 [2.05, 5.31]

1.2 Other surgery

2

201

Risk Ratio (M‐H, Fixed, 95% CI)

2.14 [1.40, 3.27]

2 Participants using rescue medication over 6 to 8 hours Show forest plot

5

446

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.59, 0.80]

2.1 6 hours

4

339

Risk Ratio (M‐H, Fixed, 95% CI)

0.73 [0.63, 0.85]

2.2 8 hours

1

107

Risk Ratio (M‐H, Fixed, 95% CI)

0.49 [0.30, 0.82]

3 Participants with any adverse event Show forest plot

3

258

Risk Ratio (M‐H, Fixed, 95% CI)

0.63 [0.32, 1.26]
Figuras y tablas -
Comparison 5. Dexketoprofen 10/12.5 mg versus placebo
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Comparison 6. Dexketoprofen 20/25 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

6

523

Risk Ratio (M‐H, Fixed, 95% CI)

3.27 [2.40, 4.46]

1.1 Dental surgery

4

322

Risk Ratio (M‐H, Fixed, 95% CI)

4.32 [2.72, 6.88]

1.2 Other surgery

2

201

Risk Ratio (M‐H, Fixed, 95% CI)

2.34 [1.56, 3.53]

2 Participants using rescue medication over 6 to 8 hours Show forest plot

7

597

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.62, 0.78]

2.1 6 hours

5

407

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.59, 0.79]

2.2 8 hours

2

190

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.57, 0.89]

3 Participants with any adverse event Show forest plot

5

413

Risk Ratio (M‐H, Fixed, 95% CI)

1.30 [0.82, 2.08]
Figuras y tablas -
Comparison 6. Dexketoprofen 20/25 mg versus placebo
Ir a la tabla de la revisión