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Cochrane Database of Systematic Reviews

Pentoxifilina para la hepatitis alcohólica

Información

DOI:
https://doi.org/10.1002/14651858.CD007339.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 07 octubre 2009see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Hepatobiliar

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Contraer

Autores

  • Kate Whitfield

    Correspondencia a: Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

    [email protected]

  • Andrea Rambaldi

    Cochrane Hepato‐Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Jørn Wetterslev

    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Christian Gluud

    Cochrane Hepato‐Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Contributions of authors

CG and AR conceived the idea of the review and provided a clinical perspective. KW and AR screened the search results, selected publications for inclusion and exclusion according to the eligibility criteria, extracted data, and made the risk of bias judgements. KW drafted the review and performed the meta‐analyses. AR, JW and CG revised the review. JW performed the trial sequential analyses. KW, JW, CG interpreted the data and results. CG provided general advice on the review provided a methodological perspective.

Sources of support

Internal sources

  • The Copenhagen Trial Unit, Denmark.

External sources

  • No sources of support supplied

Declarations of interest

None known.

Acknowledgements

We thank the participants and investigators who took part in the clinical trials. We thank Dimitrinka Nikolova for her expertise and guidance. We thank Nader Salas and Styrbjørn Birch for invaluable IT assistance. Thank you to Didier Lebrec for clarifying information relating to the randomised clinical trial he participated in.

Peer Reviewers: H Tilg, Austria, IN Guha, S Stewart, UK.
Contact Editor: Rosa Simonetti, Italy.

Version history

Published

Title

Stage

Authors

Version

2009 Oct 07

Pentoxifylline for alcoholic hepatitis

Review

Kate Whitfield, Andrea Rambaldi, Jørn Wetterslev, Christian Gluud

https://doi.org/10.1002/14651858.CD007339.pub2

2009 Jul 08

Pentoxifylline for alcoholic hepatitis

Protocol

Kate Whitfield, Andrea Rambaldi, Christian Gluud

https://doi.org/10.1002/14651858.CD007339

Differences between protocol and review

The risk of bias descriptions (funding, early stopping) have been updated in the review, according to The Cochrane Hepato‐Biliary group module. In the review 'weighted mean difference' is now called 'mean difference'. We now describe the statistical tests we used for outcome measure data that are reported in only one trial. The secondary outcome measure that was described as 'Liver biochemistry and function' is now described as 'Liver and kidney biochemistry and function'. For the meta‐analyses we reported the results from the fixed‐effect model, unless there were discrepancies between the statistical significance in the results of the two models, in which case we report both. We removed the proposal to perform 'carry‐forward analysis' as a sensitivity analysis, because for the outcome measure mortality it would yield the same result as 'good outcome analysis'. We performed a post‐hoc outcome measure on the effect of pentoxifylline on TNF levels.