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Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 1

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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Forest plot of comparison: 1 Vitamin D versus placebo, outcome: 1.2 Serum calcium (absolute final) [mmol/L].
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Figure 2

Forest plot of comparison: 1 Vitamin D versus placebo, outcome: 1.2 Serum calcium (absolute final) [mmol/L].

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Forest plot of comparison: 1 Vitamin D versus placebo, outcome: 1.3 25(OH)D [ng/ml].
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Figure 3

Forest plot of comparison: 1 Vitamin D versus placebo, outcome: 1.3 25(OH)D [ng/ml].

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Forest plot of comparison: 1 Vitamin D versus placebo, outcome: 1.5 PTH levels (absolute final) [pmol/L].
Figuras y tablas -
Figure 4

Forest plot of comparison: 1 Vitamin D versus placebo, outcome: 1.5 PTH levels (absolute final) [pmol/L].

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Comparison 1 Vitamin D versus placebo, Outcome 1 Serum calcium change (mmol/L).
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Analysis 1.1

Comparison 1 Vitamin D versus placebo, Outcome 1 Serum calcium change (mmol/L).

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Comparison 1 Vitamin D versus placebo, Outcome 2 Serum calcium (absolute final).
Figuras y tablas -
Analysis 1.2

Comparison 1 Vitamin D versus placebo, Outcome 2 Serum calcium (absolute final).

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Comparison 1 Vitamin D versus placebo, Outcome 3 25(OH)D.
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Analysis 1.3

Comparison 1 Vitamin D versus placebo, Outcome 3 25(OH)D.

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Comparison 1 Vitamin D versus placebo, Outcome 4 1,25(OH)2D (absolute final).
Figuras y tablas -
Analysis 1.4

Comparison 1 Vitamin D versus placebo, Outcome 4 1,25(OH)2D (absolute final).

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Comparison 1 Vitamin D versus placebo, Outcome 5 PTH levels (absolute final).
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Analysis 1.5

Comparison 1 Vitamin D versus placebo, Outcome 5 PTH levels (absolute final).

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Comparison 1 Vitamin D versus placebo, Outcome 6 PTH levels (change from baseline).
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Analysis 1.6

Comparison 1 Vitamin D versus placebo, Outcome 6 PTH levels (change from baseline).

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Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 1 Whole body bone mineral content change (g).
Figuras y tablas -
Analysis 2.1

Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 1 Whole body bone mineral content change (g).

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Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 2 Lumbar spine z score.
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Analysis 2.2

Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 2 Lumbar spine z score.

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Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 3 Lumbar spine bone mineral density (% change).
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Analysis 2.3

Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 3 Lumbar spine bone mineral density (% change).

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Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 4 Hip bone mineral density (% change).
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Analysis 2.4

Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 4 Hip bone mineral density (% change).

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Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 5 Distal forearm bone mineral density (% change).
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Analysis 2.5

Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 5 Distal forearm bone mineral density (% change).

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Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 6 Hip bone mineral density (change).
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Analysis 2.6

Comparison 2 Post‐hoc analysis: Vitamin D versus placebo, Outcome 6 Hip bone mineral density (change).

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Comparison 1. Vitamin D versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Serum calcium change (mmol/L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

1.1 Up to 12 months

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Serum calcium (absolute final) Show forest plot

2

51

Mean Difference (IV, Fixed, 95% CI)

0.02 [‐0.02, 0.06]

2.1 Up to 3 months

1

30

Mean Difference (IV, Fixed, 95% CI)

0.02 [‐0.04, 0.08]

2.2 Up to 6 months

1

21

Mean Difference (IV, Fixed, 95% CI)

0.02 [‐0.03, 0.07]

3 25(OH)D Show forest plot

3

81

Mean Difference (IV, Fixed, 95% CI)

7.24 [5.01, 9.46]

3.1 Up to 3 months (final values)

1

30

Mean Difference (IV, Fixed, 95% CI)

8.70 [6.24, 11.16]

3.2 Up to 6 months (final values)

1

21

Mean Difference (IV, Fixed, 95% CI)

1.20 [‐4.56, 6.96]

3.3 Up to 12 months (change from baseline)

1

30

Mean Difference (IV, Fixed, 95% CI)

‐2.60 [‐15.41, 10.21]

4 1,25(OH)2D (absolute final) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Up to 6 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 PTH levels (absolute final) Show forest plot

2

51

Mean Difference (IV, Fixed, 95% CI)

‐0.93 [‐5.22, 3.36]

5.1 Up to 3 months

1

21

Mean Difference (IV, Fixed, 95% CI)

‐7.60 [‐20.51, 5.31]

5.2 Up to 6 months

1

30

Mean Difference (IV, Fixed, 95% CI)

‐0.10 [‐4.65, 4.45]

6 PTH levels (change from baseline) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

6.1 Up to 12 months

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Vitamin D versus placebo
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Comparison 2. Post‐hoc analysis: Vitamin D versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Whole body bone mineral content change (g) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Up to 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Lumbar spine z score Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Up to 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Lumbar spine bone mineral density (% change) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3.1 Up to 12 months

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Hip bone mineral density (% change) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4.1 Up to 12 months

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Distal forearm bone mineral density (% change) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5.1 Up to 12 months

1

Mean Difference (Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Hip bone mineral density (change) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 Up to 12 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 2. Post‐hoc analysis: Vitamin D versus placebo
Ir a la tabla de la revisión