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'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 1

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

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Forest plot of comparison: 1 Number of patients with > 50% pain relief over 4 hours, outcome: 1.1 Propacetamol or paracetamol versus p lacebo.
Figuras y tablas -
Figure 2

Forest plot of comparison: 1 Number of patients with > 50% pain relief over 4 hours, outcome: 1.1 Propacetamol or paracetamol versus p lacebo.

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Forest plot of comparison: 2 Number of patients with > 50% pain relief over 6 hours, outcome: 2.1 Propacetamol or paracetamol versus placebo.
Figuras y tablas -
Figure 3

Forest plot of comparison: 2 Number of patients with > 50% pain relief over 6 hours, outcome: 2.1 Propacetamol or paracetamol versus placebo.

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Forest plot of comparison: 15 Pain on infusion, outcome: 15.3 Propacetamol versus paracetamol.
Figuras y tablas -
Figure 4

Forest plot of comparison: 15 Pain on infusion, outcome: 15.3 Propacetamol versus paracetamol.

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Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 1 Propacetamol or paracetamol vs placebo.
Figuras y tablas -
Analysis 1.1

Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 1 Propacetamol or paracetamol vs placebo.

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Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 2 Propacetamol vs NSAIDs.
Figuras y tablas -
Analysis 1.2

Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 2 Propacetamol vs NSAIDs.

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Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 3 Propacetamol vs opioids.
Figuras y tablas -
Analysis 1.3

Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 3 Propacetamol vs opioids.

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Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 4 Propacetamol vs paracetamol.
Figuras y tablas -
Analysis 1.4

Comparison 1 Number of patients with > 50% pain relief over 4 hours, Outcome 4 Propacetamol vs paracetamol.

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Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 1 Propacetamol or paracetamol vs placebo.
Figuras y tablas -
Analysis 2.1

Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 1 Propacetamol or paracetamol vs placebo.

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Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 2 Propacetamol vs NSAIDs.
Figuras y tablas -
Analysis 2.2

Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 2 Propacetamol vs NSAIDs.

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Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 3 Propacetamol vs opioids.
Figuras y tablas -
Analysis 2.3

Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 3 Propacetamol vs opioids.

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Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 4 Propacetamol vs paracetamol.
Figuras y tablas -
Analysis 2.4

Comparison 2 Number of patients with > 50% pain relief over 6 hours, Outcome 4 Propacetamol vs paracetamol.

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Comparison 3 Number of patients requiring rescue medication, Outcome 1 Propacetamol or paracetamol vs placebo.
Figuras y tablas -
Analysis 3.1

Comparison 3 Number of patients requiring rescue medication, Outcome 1 Propacetamol or paracetamol vs placebo.

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Comparison 3 Number of patients requiring rescue medication, Outcome 2 Propacetamol vs NSAIDs.
Figuras y tablas -
Analysis 3.2

Comparison 3 Number of patients requiring rescue medication, Outcome 2 Propacetamol vs NSAIDs.

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Comparison 3 Number of patients requiring rescue medication, Outcome 3 Propacetamol vs opioids.
Figuras y tablas -
Analysis 3.3

Comparison 3 Number of patients requiring rescue medication, Outcome 3 Propacetamol vs opioids.

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Comparison 3 Number of patients requiring rescue medication, Outcome 4 Propacetamol vs paracetamol.
Figuras y tablas -
Analysis 3.4

Comparison 3 Number of patients requiring rescue medication, Outcome 4 Propacetamol vs paracetamol.

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Comparison 4 Time to rescue medication (minutes), Outcome 1 Propacetamol or paracetamol vs placebo.
Figuras y tablas -
Analysis 4.1

Comparison 4 Time to rescue medication (minutes), Outcome 1 Propacetamol or paracetamol vs placebo.

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Comparison 5 Opioid consumption (IV morphine equivalents) over 4 hours, Outcome 1 Propacetamol or paracetamol vs placebo.
Figuras y tablas -
Analysis 5.1

Comparison 5 Opioid consumption (IV morphine equivalents) over 4 hours, Outcome 1 Propacetamol or paracetamol vs placebo.

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Comparison 5 Opioid consumption (IV morphine equivalents) over 4 hours, Outcome 2 Propacetamol or paracetamol vs NSAIDs.
Figuras y tablas -
Analysis 5.2

Comparison 5 Opioid consumption (IV morphine equivalents) over 4 hours, Outcome 2 Propacetamol or paracetamol vs NSAIDs.

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Comparison 5 Opioid consumption (IV morphine equivalents) over 4 hours, Outcome 3 Propacetamol vs opioids.
Figuras y tablas -
Analysis 5.3

Comparison 5 Opioid consumption (IV morphine equivalents) over 4 hours, Outcome 3 Propacetamol vs opioids.

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Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 1 Propacetamol or paracetamol vs placebo.
Figuras y tablas -
Analysis 6.1

Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 1 Propacetamol or paracetamol vs placebo.

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Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 2 Propacetamol vs NSAIDs.
Figuras y tablas -
Analysis 6.2

Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 2 Propacetamol vs NSAIDs.

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Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 3 Propacetamol vs opioids.
Figuras y tablas -
Analysis 6.3

Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 3 Propacetamol vs opioids.

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Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 4 Propacetamol vs paracetamol.
Figuras y tablas -
Analysis 6.4

Comparison 6 Opioid consumption (IV morphine equivalents) over 6 hours, Outcome 4 Propacetamol vs paracetamol.

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Comparison 7 Global evaluation: propacetamol or paracetamol vs placebo, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.
Figuras y tablas -
Analysis 7.1

Comparison 7 Global evaluation: propacetamol or paracetamol vs placebo, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.

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Comparison 8 Global evaluation: propacetamol or paracetamol vs NSAIDs, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.
Figuras y tablas -
Analysis 8.1

Comparison 8 Global evaluation: propacetamol or paracetamol vs NSAIDs, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.

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Comparison 9 Global evaluation: propacetamol vs opioids, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.
Figuras y tablas -
Analysis 9.1

Comparison 9 Global evaluation: propacetamol vs opioids, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.

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Comparison 10 Global evaluation: propacetamol vs paracetamol, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.
Figuras y tablas -
Analysis 10.1

Comparison 10 Global evaluation: propacetamol vs paracetamol, Outcome 1 Global evaluation rated as good/satisfied or excellent/very satisfied.

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Comparison 11 Global evaluation using VAS (0 to 10), Outcome 1 Propacetamol vs placebo.
Figuras y tablas -
Analysis 11.1

Comparison 11 Global evaluation using VAS (0 to 10), Outcome 1 Propacetamol vs placebo.

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Comparison 11 Global evaluation using VAS (0 to 10), Outcome 2 Propacetamol vs opioids.
Figuras y tablas -
Analysis 11.2

Comparison 11 Global evaluation using VAS (0 to 10), Outcome 2 Propacetamol vs opioids.

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Comparison 12 Number of patients with adverse events: propacetamol or paracetamol vs placebo, Outcome 1 Adverse events.
Figuras y tablas -
Analysis 12.1

Comparison 12 Number of patients with adverse events: propacetamol or paracetamol vs placebo, Outcome 1 Adverse events.

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Comparison 13 Number of patients with adverse events: propacetamol vs NSAIDs, Outcome 1 Propacetamol vs NSAIDs.
Figuras y tablas -
Analysis 13.1

Comparison 13 Number of patients with adverse events: propacetamol vs NSAIDs, Outcome 1 Propacetamol vs NSAIDs.

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Comparison 14 Number of patients with adverse events: propacetamol vs opioids, Outcome 1 Propacetamol vs opioids.
Figuras y tablas -
Analysis 14.1

Comparison 14 Number of patients with adverse events: propacetamol vs opioids, Outcome 1 Propacetamol vs opioids.

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Comparison 15 Pain on infusion, Outcome 1 Propacetamol vs placebo.
Figuras y tablas -
Analysis 15.1

Comparison 15 Pain on infusion, Outcome 1 Propacetamol vs placebo.

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Comparison 15 Pain on infusion, Outcome 2 Paracetamol vs placebo.
Figuras y tablas -
Analysis 15.2

Comparison 15 Pain on infusion, Outcome 2 Paracetamol vs placebo.

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Comparison 15 Pain on infusion, Outcome 3 Propacetamol vs paracetamol.
Figuras y tablas -
Analysis 15.3

Comparison 15 Pain on infusion, Outcome 3 Propacetamol vs paracetamol.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 1 Nausea.
Figuras y tablas -
Analysis 16.1

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 1 Nausea.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 2 Vomiting.
Figuras y tablas -
Analysis 16.2

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 2 Vomiting.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 3 Nausea/vomiting.
Figuras y tablas -
Analysis 16.3

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 3 Nausea/vomiting.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 4 Headache.
Figuras y tablas -
Analysis 16.4

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 4 Headache.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 5 Pruritus.
Figuras y tablas -
Analysis 16.5

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 5 Pruritus.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 6 Respiratory depression.
Figuras y tablas -
Analysis 16.6

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 6 Respiratory depression.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 7 Sedation.
Figuras y tablas -
Analysis 16.7

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 7 Sedation.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 8 Vertigo/dizziness.
Figuras y tablas -
Analysis 16.8

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 8 Vertigo/dizziness.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 9 Fatigue.
Figuras y tablas -
Analysis 16.9

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 9 Fatigue.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 10 Fever.
Figuras y tablas -
Analysis 16.10

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 10 Fever.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 11 GI disorders: constipation, epigastric pain, abdominal distension.
Figuras y tablas -
Analysis 16.11

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 11 GI disorders: constipation, epigastric pain, abdominal distension.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 12 Urinary retention.
Figuras y tablas -
Analysis 16.12

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 12 Urinary retention.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 13 Allergy/skin rash/local reaction.
Figuras y tablas -
Analysis 16.13

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 13 Allergy/skin rash/local reaction.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 14 Heart rate disorders.
Figuras y tablas -
Analysis 16.14

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 14 Heart rate disorders.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 15 Malaise.
Figuras y tablas -
Analysis 16.15

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 15 Malaise.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 16 Bleeding.
Figuras y tablas -
Analysis 16.16

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 16 Bleeding.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 17 Liver function test abnormalities.
Figuras y tablas -
Analysis 16.17

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 17 Liver function test abnormalities.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 18 Hypotension.
Figuras y tablas -
Analysis 16.18

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 18 Hypotension.

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Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 19 AEs causing patient to withdraw from study.
Figuras y tablas -
Analysis 16.19

Comparison 16 Individual adverse events: propacetamol or paracetamol vs placebo, Outcome 19 AEs causing patient to withdraw from study.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 1 Nausea.
Figuras y tablas -
Analysis 17.1

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 1 Nausea.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 2 Vomiting.
Figuras y tablas -
Analysis 17.2

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 2 Vomiting.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 3 Nausea/vomiting.
Figuras y tablas -
Analysis 17.3

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 3 Nausea/vomiting.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 4 Headache.
Figuras y tablas -
Analysis 17.4

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 4 Headache.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 5 Pruritus.
Figuras y tablas -
Analysis 17.5

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 5 Pruritus.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 6 Hypotension.
Figuras y tablas -
Analysis 17.6

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 6 Hypotension.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 7 Sedation.
Figuras y tablas -
Analysis 17.7

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 7 Sedation.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 8 GI disorders.
Figuras y tablas -
Analysis 17.8

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 8 GI disorders.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 9 Urinary retention.
Figuras y tablas -
Analysis 17.9

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 9 Urinary retention.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 10 Allergy/skin rash/local reaction.
Figuras y tablas -
Analysis 17.10

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 10 Allergy/skin rash/local reaction.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 11 Heart rate disorders.
Figuras y tablas -
Analysis 17.11

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 11 Heart rate disorders.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 12 Liver function test abnormalities.
Figuras y tablas -
Analysis 17.12

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 12 Liver function test abnormalities.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 13 Malaise.
Figuras y tablas -
Analysis 17.13

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 13 Malaise.

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Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 14 Bleeding.
Figuras y tablas -
Analysis 17.14

Comparison 17 Individual adverse events: propacetamol or paracetamol vs NSAIDs, Outcome 14 Bleeding.

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Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 1 Nausea.
Figuras y tablas -
Analysis 18.1

Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 1 Nausea.

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Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 2 Vomiting.
Figuras y tablas -
Analysis 18.2

Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 2 Vomiting.

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Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 3 Nausea/vomiting.
Figuras y tablas -
Analysis 18.3

Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 3 Nausea/vomiting.

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Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 4 Pruritus.
Figuras y tablas -
Analysis 18.4

Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 4 Pruritus.

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Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 5 GI disorders.
Figuras y tablas -
Analysis 18.5

Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 5 GI disorders.

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Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 6 Heart rate disorders.
Figuras y tablas -
Analysis 18.6

Comparison 18 Individual adverse events: propacetamol vs opioids, Outcome 6 Heart rate disorders.

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Table 1. Efficacy outcomes: IV propacetamol and/or IV paracetamol vs placebo

Outcome

Statistical method

Intervention

Number of studies, total patients enrolled*

Overall estimate (95% confidence interval)†

At least 50% pain relief over 4 hours (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

8, 807

3, 367

9, 1072

2.4 (1.9 to 3.0)

12.1 (4.1 to 35.5)

2.9 (2.3 to 3.7)

At least 50% pain relief over 6 hours (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

6, 662

3, 367

7, 927

2.8 (1.9 to 4.0)

16.2 (4.2 to 62.0)

3.8 (2.7 to 5.4)

Requirement for additional analgesia (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

3, 204

3, 340

6, 544

0.5 (0.4 to 0.7)

0.7 (0.7 to 0.8)

0.6 (0.6 to 0.7)

Time to additional analgesia (mins)

Mean difference

Propacetamol

Paracetamol

Combined data

3, 316

1, 74

4, 390

23.7 (13.8 to 33.6)

56.0 (30.2 to 81.8)

27.9 (18.6 to 37.2)

Opioid consumption over 4 hours (IV morphine equivalents, mg)

Mean difference

Propacetamol

Paracetamol

Combined data

2, 114

1, 40

3, 154

‐2.0 (‐3.2 to ‐1.0)

‐1.2 (‐1.6 to ‐0.8)

‐1.3 (‐1.7 to ‐0.9)

Opioid consumption over 6 hours (IV morphine equivalents, mg)

Mean difference

Propacetamol

Paracetamol

Combined data

6, 399

2, 141

7, 488

‐2.9 (‐4.4 to ‐1.4)

‐2.0 (‐2.6 to ‐1.4)

‐2.1 (‐2.6 to ‐1.6)

Global evaluation: (“good/satisfied” or better, n/N)

Risk ratio

 

Propacetamol

Paracetamol

Combined data

8, 1114

4, 392

10, 1404

1.3 (1.3 to 1.5)

1.6 (1.3 to 2.1)

1.4 (1.3 to 1.5)

Global evaluation: VAS (0 to 10)

Mean difference

Propacetamol

Paracetamol

Combined data

2, 282

no data

NA

1.6 (1.0 to 2.2)

no data

NA

*Combined numbers may be less than individual totals due to studies including both propacetamol and IV paracetamol arms.

†Bolded data are statistically significant.

IV = intravenous; NA = not applicable; VAS = visual analog scale
Figuras y tablas -
Table 1. Efficacy outcomes: IV propacetamol and/or IV paracetamol vs placebo
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Table 2. Efficacy outcomes: IV propacetamol and/or IV paracetamol vs NSAIDs

Outcome

Statistical method

Intervention

Number of studies, total patients enrolled

Overall estimate (95% confidence interval)†

At least 50% pain relief over 4 hours (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

3, 223

No data

NA

1.1 (0.9 to 1.3)

No data

NA

At least 50% pain relief over 6 hours (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

2, 143

No data

NA

0.8 (0.6 to 1.0)

No data

NA

Requirement for additional analgesia (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

3, 189

No data

NA

1.2 (0.9 to 1.8)

No data

NA

Time to additional analgesia (mins)

Mean difference

Propacetamol

Paracetamol

Combined data

No data

No data

NA

No data

No data

NA

Opioid consumption over 4 hours (IV morphine equivalents, mg)

Mean difference

Propacetamol

Paracetamol

Combined data

1, 176

1, 78

2, 254

‐0.2 (‐0.4 to ‐0.0)

0.1 (‐1.4 to 1.6)

‐0.2 (‐0.4 to ‐0.0)

Opioid consumption over 6 hours (IV morphine equivalents, mg)

Mean difference

Propacetamol

Paracetamol

Combined data

5, 380

No data

NA

‐0.1 (‐0.4 to 0.1)

No data

NA

Global evaluation: (“good/satisfied” or better, n/N)

Risk ratio

 

Propacetamol

Paracetamol

Combined data

5, 548

2, 65

7, 613

0.9 (0.8 to 1.0)

1.0 (0.9 to 1.1)

1.4 (1.3 to 1.5)

Global evaluation: VAS (0 to 10)

Mean difference

Propacetamol

Paracetamol

Combined data

No data

No data

NA

No data

No data

NA

†Bolded data are statistically significant.

IV = intravenous; NA = not applicable; VAS = visual analog scale
Figuras y tablas -
Table 2. Efficacy outcomes: IV propacetamol and/or IV paracetamol vs NSAIDs
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Table 3. Efficacy outcomes: IV propacetamol and/or IV paracetamol vs opioids

Outcome

Statistical method

Intervention

Number of studies, total patients enrolled

Overall estimate (95% confidence interval)†

At least 50% pain relief over 4 hours (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

1, 61

No data

NA

1.2 (0.8 to 1.6)

No data

NA

At least 50% pain relief over 6 hours (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

1, 40

No data

NA

1.0 (0.8 to 1.1)

No data

NA

Requirement for additional analgesia (n/N)

Risk ratios

Propacetamol

Paracetamol

Combined data

2, 139

No data

NA

1.8 (0.7 to 4.6)

No data

NA

Time to additional analgesia (mins)

Mean difference

Propacetamol

Paracetamol

Combined data

No data

No data

NA

No data

No data

NA

Opioid consumption over 4 hours (IV morphine equivalents, mg)

Mean difference

Propacetamol

Paracetamol

Combined data

1, 80

No data

NA

‐1.0 (‐3.1 to 1.1)

No data

NA

Opioid consumption over 6 hours (IV morphine equivalents, mg)

Mean difference

Propacetamol

Paracetamol

Combined data

1, 80

No data

NA

‐0.5 (‐3.1 to 2.0)

No data

NA

Global evaluation: (“good/satisfied” or better, n/N)

Risk ratio

 

Propacetamol

Paracetamol

Combined data

2, 116

No data

NA

0.9 (0.8 to 1.1)

No data

NA

Global evaluation: VAS (0 to 10)

Mean difference

Propacetamol

Paracetamol

Combined data

2, 141

No data

NA

0.4 (‐0.2 to 1.0)

No data

NA

†No data are statistically significant.

IV = intravenous; NA = not applicable; VAS = visual analog scale
Figuras y tablas -
Table 3. Efficacy outcomes: IV propacetamol and/or IV paracetamol vs opioids
Ir a la tabla de la revisión
Table 4. Efficacy outcomes: IV propacetamol vs IV paracetamol

Outcome

Statistical method

Number of studies, total patients enrolled

Overall estimate (95% confidence interval)†

At least 50% pain relief over 4 hours (n/N)

Risk ratios

3, 361

 

1.0 (0.8 to 1.2)

 

At least 50% pain relief over 6 hours (n/N)

Risk ratios

3, 361

 

0.9 (0.7 to 1.2)

 

Requirement for additional analgesia (n/N)

Risk ratios

1, 161

1.3 (0.8 to 2.2)

Time to additional analgesia (mins)

Mean difference

No data

 

No data

 

Opioid consumption over 4 hours (IV morphine equivalents, mg)

Mean difference

No data

 

No data

 

Opioid consumption over 6 hours (IV morphine equivalents, mg)

Mean difference

1, 98

 

‐0.4 (‐4.2 to 3.4)

 

Global evaluation: (“good/satisfied” or better, n/N)

Risk ratio

 

2, 263

 

1.0 (0.8 to 1.2)

 

Global evaluation: VAS (0 to 10)

Mean difference

No data

 

No data

†No data are statistically significant.

IV = intravenous; NA = not applicable; VAS = visual analog scale
Figuras y tablas -
Table 4. Efficacy outcomes: IV propacetamol vs IV paracetamol
Ir a la tabla de la revisión
Comparison 1. Number of patients with > 50% pain relief over 4 hours

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol or paracetamol vs placebo Show forest plot

9

1174

Risk Ratio (M‐H, Fixed, 95% CI)

2.92 [2.32, 3.67]

1.1 Propacetamol vs placebo

8

807

Risk Ratio (M‐H, Fixed, 95% CI)

2.37 [1.88, 2.97]

1.2 Paracetamol vs placebo

3

367

Risk Ratio (M‐H, Fixed, 95% CI)

12.11 [4.13, 35.47]

2 Propacetamol vs NSAIDs Show forest plot

3

223

Risk Ratio (M‐H, Fixed, 95% CI)

1.08 [0.86, 1.34]

3 Propacetamol vs opioids Show forest plot

1

61

Risk Ratio (M‐H, Fixed, 95% CI)

1.16 [0.85, 1.59]

4 Propacetamol vs paracetamol Show forest plot

3

361

Risk Ratio (M‐H, Fixed, 95% CI)

0.98 [0.77, 1.24]
Figuras y tablas -
Comparison 1. Number of patients with > 50% pain relief over 4 hours
Ir a la tabla de la revisión
Comparison 2. Number of patients with > 50% pain relief over 6 hours

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol or paracetamol vs placebo Show forest plot

7

1029

Risk Ratio (M‐H, Fixed, 95% CI)

3.81 [2.66, 5.44]

1.1 Propacetamol vs placebo

6

662

Risk Ratio (M‐H, Fixed, 95% CI)

2.76 [1.92, 3.97]

1.2 Paracetamol vs placebo

3

367

Risk Ratio (M‐H, Fixed, 95% CI)

16.22 [4.25, 61.96]

2 Propacetamol vs NSAIDs Show forest plot

2

143

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.56, 1.02]

3 Propacetamol vs opioids Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.95 [0.83, 1.09]

4 Propacetamol vs paracetamol Show forest plot

3

361

Risk Ratio (M‐H, Fixed, 95% CI)

0.94 [0.73, 1.20]
Figuras y tablas -
Comparison 2. Number of patients with > 50% pain relief over 6 hours
Ir a la tabla de la revisión
Comparison 3. Number of patients requiring rescue medication

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol or paracetamol vs placebo Show forest plot

6

544

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.58, 0.74]

1.1 Propacetamol vs placebo

3

204

Risk Ratio (M‐H, Fixed, 95% CI)

0.49 [0.35, 0.69]

1.2 Paracetamol vs placebo

3

340

Risk Ratio (M‐H, Fixed, 95% CI)

0.73 [0.66, 0.82]

2 Propacetamol vs NSAIDs Show forest plot

3

189

Risk Ratio (M‐H, Fixed, 95% CI)

1.23 [0.86, 1.77]

3 Propacetamol vs opioids Show forest plot

2

139

Risk Ratio (M‐H, Fixed, 95% CI)

1.83 [0.72, 4.64]

4 Propacetamol vs paracetamol Show forest plot

1

161

Risk Ratio (M‐H, Fixed, 95% CI)

1.33 [0.82, 2.17]
Figuras y tablas -
Comparison 3. Number of patients requiring rescue medication
Ir a la tabla de la revisión
Comparison 4. Time to rescue medication (minutes)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol or paracetamol vs placebo Show forest plot

4

390

Mean Difference (IV, Fixed, 95% CI)

27.89 [18.62, 37.16]

1.1 Propacetamol vs placebo

3

316

Mean Difference (IV, Fixed, 95% CI)

23.72 [13.79, 33.65]

1.2 Paracetamol vs placebo

1

74

Mean Difference (IV, Fixed, 95% CI)

56.00 [30.19, 81.81]
Figuras y tablas -
Comparison 4. Time to rescue medication (minutes)
Ir a la tabla de la revisión
Comparison 5. Opioid consumption (IV morphine equivalents) over 4 hours

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol or paracetamol vs placebo Show forest plot

3

154

Mean Difference (IV, Fixed, 95% CI)

‐1.32 [‐1.72, ‐0.91]

1.1 Propacetamol vs placebo

2

114

Mean Difference (IV, Fixed, 95% CI)

‐2.05 [‐3.15, ‐0.95]

1.2 Paracetamol vs placebo

1

40

Mean Difference (IV, Fixed, 95% CI)

‐1.20 [‐1.64, ‐0.76]

2 Propacetamol or paracetamol vs NSAIDs Show forest plot

2

254

Mean Difference (IV, Fixed, 95% CI)

‐0.20 [‐0.37, ‐0.02]

2.1 Propacetamol vs NSAIDs

1

176

Mean Difference (IV, Fixed, 95% CI)

‐0.20 [‐0.38, ‐0.02]

2.2 Paracetamol vs NSAIDs

1

78

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐1.41, 1.61]

3 Propacetamol vs opioids Show forest plot

1

80

Mean Difference (IV, Fixed, 95% CI)

‐1.0 [‐3.09, 1.09]
Figuras y tablas -
Comparison 5. Opioid consumption (IV morphine equivalents) over 4 hours
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Comparison 6. Opioid consumption (IV morphine equivalents) over 6 hours

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol or paracetamol vs placebo Show forest plot

7

540

Mean Difference (IV, Fixed, 95% CI)

‐2.10 [‐2.65, ‐1.55]

1.1 Propacetamol vs placebo

6

399

Mean Difference (IV, Fixed, 95% CI)

‐2.88 [‐4.39, ‐1.37]

1.2 Paracetamol vs placebo

2

141

Mean Difference (IV, Fixed, 95% CI)

‐1.98 [‐2.57, ‐1.38]

2 Propacetamol vs NSAIDs Show forest plot

5

380

Mean Difference (IV, Fixed, 95% CI)

‐0.14 [‐0.39, 0.11]

3 Propacetamol vs opioids Show forest plot

1

80

Mean Difference (IV, Fixed, 95% CI)

‐0.5 [‐3.01, 2.01]

4 Propacetamol vs paracetamol Show forest plot

1

98

Mean Difference (IV, Fixed, 95% CI)

‐0.40 [‐4.15, 3.35]
Figuras y tablas -
Comparison 6. Opioid consumption (IV morphine equivalents) over 6 hours
Ir a la tabla de la revisión
Comparison 7. Global evaluation: propacetamol or paracetamol vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Global evaluation rated as good/satisfied or excellent/very satisfied Show forest plot

10

1506

Risk Ratio (M‐H, Fixed, 95% CI)

1.37 [1.26, 1.49]

1.1 Propacetamol vs placebo

8

1114

Risk Ratio (M‐H, Fixed, 95% CI)

1.32 [1.21, 1.44]

1.2 Paracetamol vs placebo

4

392

Risk Ratio (M‐H, Fixed, 95% CI)

1.64 [1.30, 2.07]
Figuras y tablas -
Comparison 7. Global evaluation: propacetamol or paracetamol vs placebo
Ir a la tabla de la revisión
Comparison 8. Global evaluation: propacetamol or paracetamol vs NSAIDs

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Global evaluation rated as good/satisfied or excellent/very satisfied Show forest plot

7

613

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.84, 1.01]

1.1 Propacetamol vs NSAIDs

5

548

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.82, 1.01]

1.2 Paracetamol vs NSAIDs

2

65

Risk Ratio (M‐H, Fixed, 95% CI)

1.0 [0.92, 1.08]
Figuras y tablas -
Comparison 8. Global evaluation: propacetamol or paracetamol vs NSAIDs
Ir a la tabla de la revisión
Comparison 9. Global evaluation: propacetamol vs opioids

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Global evaluation rated as good/satisfied or excellent/very satisfied Show forest plot

2

116

Risk Ratio (M‐H, Fixed, 95% CI)

0.94 [0.79, 1.11]
Figuras y tablas -
Comparison 9. Global evaluation: propacetamol vs opioids
Ir a la tabla de la revisión
Comparison 10. Global evaluation: propacetamol vs paracetamol

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Global evaluation rated as good/satisfied or excellent/very satisfied Show forest plot

2

263

Risk Ratio (M‐H, Fixed, 95% CI)

0.98 [0.83, 1.15]
Figuras y tablas -
Comparison 10. Global evaluation: propacetamol vs paracetamol
Ir a la tabla de la revisión
Comparison 11. Global evaluation using VAS (0 to 10)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol vs placebo Show forest plot

2

282

Mean Difference (IV, Fixed, 95% CI)

1.64 [1.04, 2.25]

2 Propacetamol vs opioids Show forest plot

2

141

Mean Difference (IV, Fixed, 95% CI)

0.40 [‐0.18, 0.98]
Figuras y tablas -
Comparison 11. Global evaluation using VAS (0 to 10)
Ir a la tabla de la revisión
Comparison 12. Number of patients with adverse events: propacetamol or paracetamol vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Adverse events Show forest plot

13

1977

Risk Ratio (M‐H, Fixed, 95% CI)

1.16 [1.03, 1.30]

1.1 Propacetamol vs placebo

10

1460

Risk Ratio (M‐H, Fixed, 95% CI)

1.19 [1.04, 1.36]

1.2 Paracetamol vs placebo

5

517

Risk Ratio (M‐H, Fixed, 95% CI)

1.07 [0.86, 1.33]
Figuras y tablas -
Comparison 12. Number of patients with adverse events: propacetamol or paracetamol vs placebo
Ir a la tabla de la revisión
Comparison 13. Number of patients with adverse events: propacetamol vs NSAIDs

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol vs NSAIDs Show forest plot

3

223

Risk Ratio (M‐H, Fixed, 95% CI)

0.93 [0.62, 1.37]
Figuras y tablas -
Comparison 13. Number of patients with adverse events: propacetamol vs NSAIDs
Ir a la tabla de la revisión
Comparison 14. Number of patients with adverse events: propacetamol vs opioids

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol vs opioids Show forest plot

1

61

Risk Ratio (M‐H, Fixed, 95% CI)

0.60 [0.29, 1.23]
Figuras y tablas -
Comparison 14. Number of patients with adverse events: propacetamol vs opioids
Ir a la tabla de la revisión
Comparison 15. Pain on infusion

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Propacetamol vs placebo Show forest plot

6

645

Risk Ratio (M‐H, Fixed, 95% CI)

13.07 [5.35, 31.98]

2 Paracetamol vs placebo Show forest plot

2

266

Risk Ratio (M‐H, Fixed, 95% CI)

1.51 [0.24, 9.60]

3 Propacetamol vs paracetamol Show forest plot

3

362

Risk Ratio (M‐H, Fixed, 95% CI)

8.31 [4.20, 16.46]
Figuras y tablas -
Comparison 15. Pain on infusion
Ir a la tabla de la revisión
Comparison 16. Individual adverse events: propacetamol or paracetamol vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Nausea Show forest plot

6

525

Risk Ratio (M‐H, Fixed, 95% CI)

1.13 [0.84, 1.52]

1.1 Propacetamol vs placebo

3

256

Risk Ratio (M‐H, Fixed, 95% CI)

1.54 [0.96, 2.48]

1.2 Paracetamol vs placebo

4

269

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.60, 1.28]

2 Vomiting Show forest plot

6

672

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.58, 1.25]

2.1 Propacetamol vs placebo

3

403

Risk Ratio (M‐H, Fixed, 95% CI)

1.46 [0.71, 3.00]

2.2 Paracetamol vs placebo

4

269

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.41, 1.04]

3 Nausea/vomiting Show forest plot

7

949

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.75, 1.11]

3.1 Propacetamol vs placebo

6

873

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.72, 1.08]

3.2 Paracetamol vs placebo

1

76

Risk Ratio (M‐H, Fixed, 95% CI)

1.43 [0.61, 3.36]

4 Headache Show forest plot

6

778

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.53, 2.01]

4.1 Propacetamol vs placebo

3

398

Risk Ratio (M‐H, Fixed, 95% CI)

1.31 [0.37, 4.57]

4.2 Paracetamol vs placebo

4

380

Risk Ratio (M‐H, Fixed, 95% CI)

0.94 [0.43, 2.08]

5 Pruritus Show forest plot

4

479

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.34, 1.11]

5.1 Propacetamol vs placebo

3

324

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.31, 1.40]

5.2 Paracetamol vs placebo

2

155

Risk Ratio (M‐H, Fixed, 95% CI)

0.57 [0.22, 1.46]

6 Respiratory depression Show forest plot

3

640

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.28, 2.60]

6.1 Propacetamol vs placebo

3

640

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.28, 2.60]

7 Sedation Show forest plot

6

339

Risk Ratio (M‐H, Fixed, 95% CI)

1.12 [0.71, 1.78]

7.1 Propacetamol vs placebo

4

225

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.65, 1.69]

7.2 Paracetamol vs placebo

2

114

Risk Ratio (M‐H, Fixed, 95% CI)

1.71 [0.41, 7.07]

8 Vertigo/dizziness Show forest plot

4

394

Risk Ratio (M‐H, Fixed, 95% CI)

1.12 [0.58, 2.16]

8.1 Propacetamol vs placebo

3

253

Risk Ratio (M‐H, Fixed, 95% CI)

1.23 [0.51, 2.96]

8.2 Paracetamol vs placebo

2

141

Risk Ratio (M‐H, Fixed, 95% CI)

0.99 [0.37, 2.65]

9 Fatigue Show forest plot

3

442

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.43, 1.78]

9.1 Propacetamol vs placebo

2

176

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.22, 1.79]

9.2 Paracetamol vs placebo

2

266

Risk Ratio (M‐H, Fixed, 95% CI)

1.14 [0.43, 3.00]

10 Fever Show forest plot

1

203

Risk Ratio (M‐H, Fixed, 95% CI)

0.18 [0.04, 0.76]

10.1 Propacetamol vs placebo

1

102

Risk Ratio (M‐H, Fixed, 95% CI)

0.17 [0.02, 1.39]

10.2 Paracetamol vs placebo

1

101

Risk Ratio (M‐H, Fixed, 95% CI)

0.18 [0.02, 1.42]

11 GI disorders: constipation, epigastric pain, abdominal distension Show forest plot

2

162

Risk Ratio (M‐H, Fixed, 95% CI)

2.04 [0.59, 7.10]

11.1 Propacetamol vs placebo

2

162

Risk Ratio (M‐H, Fixed, 95% CI)

2.04 [0.59, 7.10]

12 Urinary retention Show forest plot

3

677

Risk Ratio (M‐H, Fixed, 95% CI)

1.04 [0.65, 1.66]

12.1 Propacetamol vs placebo

3

677

Risk Ratio (M‐H, Fixed, 95% CI)

1.04 [0.65, 1.66]

13 Allergy/skin rash/local reaction Show forest plot

4

787

Risk Ratio (M‐H, Fixed, 95% CI)

2.32 [0.70, 7.65]

13.1 Propacetamol vs placebo

4

787

Risk Ratio (M‐H, Fixed, 95% CI)

2.32 [0.70, 7.65]

14 Heart rate disorders Show forest plot

1

76

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.93]

14.1 Propacetamol vs placebo

1

76

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.93]

15 Malaise Show forest plot

2

135

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.15, 6.95]

15.1 Propacetamol vs placebo

2

135

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.15, 6.95]

16 Bleeding Show forest plot

3

318

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.61, 2.16]

16.1 Propacetamol vs placebo

1

79

Risk Ratio (M‐H, Fixed, 95% CI)

1.3 [0.50, 3.40]

16.2 Paracetamol vs placebo

2

239

Risk Ratio (M‐H, Fixed, 95% CI)

1.04 [0.45, 2.41]

17 Liver function test abnormalities Show forest plot

3

342

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.36, 2.16]

17.1 Propacetamol vs placebo

2

177

Risk Ratio (M‐H, Fixed, 95% CI)

0.89 [0.35, 2.27]

17.2 Paracetamol vs placebo

1

165

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.03, 18.41]

18 Hypotension Show forest plot

3

217

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.24, 4.39]

18.1 Propacetamol vs placebo

2

177

Risk Ratio (M‐H, Fixed, 95% CI)

3.16 [0.33, 29.74]

18.2 Paracetamol vs placebo

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.01, 3.92]

19 AEs causing patient to withdraw from study Show forest plot

2

263

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.29, 3.72]

19.1 Propacetamol vs placebo

2

162

Risk Ratio (M‐H, Fixed, 95% CI)

1.36 [0.32, 5.89]

19.2 Paracetamol vs placebo

1

101

Risk Ratio (M‐H, Fixed, 95% CI)

0.35 [0.01, 8.47]
Figuras y tablas -
Comparison 16. Individual adverse events: propacetamol or paracetamol vs placebo
Ir a la tabla de la revisión
Comparison 17. Individual adverse events: propacetamol or paracetamol vs NSAIDs

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Nausea Show forest plot

4

472

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.92, 1.44]

1.1 Propacetamol vs NSAIDs

3

432

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.92, 1.44]

1.2 Paracetamol vs NSAIDs

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

1.0 [0.07, 14.90]

2 Vomiting Show forest plot

4

472

Risk Ratio (M‐H, Fixed, 95% CI)

1.27 [0.85, 1.88]

2.1 Propacetamol vs NSAIDs

3

432

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [0.81, 1.81]

2.2 Paracetamol vs NSAIDs

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

5.0 [0.26, 98.00]

3 Nausea/vomiting Show forest plot

5

278

Risk Ratio (M‐H, Fixed, 95% CI)

1.08 [0.52, 2.24]

3.1 Propacetamol vs NSAIDs

4

200

Risk Ratio (M‐H, Fixed, 95% CI)

1.2 [0.55, 2.60]

3.2 Paracetamol vs NSAIDs

1

78

Risk Ratio (M‐H, Fixed, 95% CI)

0.5 [0.05, 5.29]

4 Headache Show forest plot

2

232

Risk Ratio (M‐H, Fixed, 95% CI)

1.78 [0.76, 4.16]

4.1 Propacetamol vs NSAIDs

2

232

Risk Ratio (M‐H, Fixed, 95% CI)

1.78 [0.76, 4.16]

5 Pruritus Show forest plot

4

312

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.42, 1.73]

5.1 Propacetamol vs NSAIDs

3

272

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.37, 1.60]

5.2 Paracetamol vs NSAIDs

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.13, 69.52]

6 Hypotension Show forest plot

4

204

Risk Ratio (M‐H, Fixed, 95% CI)

0.22 [0.06, 0.85]

6.1 Propacetamol vs NSAIDs

2

139

Risk Ratio (M‐H, Fixed, 95% CI)

0.34 [0.05, 2.11]

6.2 Paracetamol vs NSAIDs

2

65

Risk Ratio (M‐H, Fixed, 95% CI)

0.15 [0.02, 1.12]

7 Sedation Show forest plot

2

70

Risk Ratio (M‐H, Fixed, 95% CI)

3.67 [0.63, 21.22]

7.1 Propacetamol vs NSAIDs

2

70

Risk Ratio (M‐H, Fixed, 95% CI)

3.67 [0.63, 21.22]

8 GI disorders Show forest plot

1

200

Risk Ratio (M‐H, Fixed, 95% CI)

0.6 [0.28, 1.31]

8.1 Propacetamol vs NSAIDs

1

200

Risk Ratio (M‐H, Fixed, 95% CI)

0.6 [0.28, 1.31]

9 Urinary retention Show forest plot

2

212

Risk Ratio (M‐H, Fixed, 95% CI)

1.14 [0.47, 2.78]

9.1 Propacetamol vs NSAIDs

2

212

Risk Ratio (M‐H, Fixed, 95% CI)

1.14 [0.47, 2.78]

10 Allergy/skin rash/local reaction Show forest plot

3

134

Risk Ratio (M‐H, Fixed, 95% CI)

0.35 [0.06, 2.12]

10.1 Propacetamol vs NSAIDs

2

109

Risk Ratio (M‐H, Fixed, 95% CI)

0.34 [0.04, 3.16]

10.2 Paracetamol vs NSAIDs

1

25

Risk Ratio (M‐H, Fixed, 95% CI)

0.36 [0.02, 8.05]

11 Heart rate disorders Show forest plot

3

266

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.38, 1.56]

11.1 Propacetamol vs NSAIDs

2

241

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.38, 2.23]

11.2 Paracetamol vs NSAIDs

1

25

Risk Ratio (M‐H, Fixed, 95% CI)

0.54 [0.17, 1.70]

12 Liver function test abnormalities Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

1.5 [0.46, 4.91]

12.1 Propacetamol vs NSAIDs

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

1.5 [0.46, 4.91]

13 Malaise Show forest plot

1

182

Risk Ratio (M‐H, Fixed, 95% CI)

1.02 [0.26, 3.96]

13.1 Propacetamol vs NSAIDs

1

182

Risk Ratio (M‐H, Fixed, 95% CI)

1.02 [0.26, 3.96]

14 Bleeding Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.01, 3.97]

14.1 Propacetamol vs NSAIDs

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.01, 3.97]
Figuras y tablas -
Comparison 17. Individual adverse events: propacetamol or paracetamol vs NSAIDs
Ir a la tabla de la revisión
Comparison 18. Individual adverse events: propacetamol vs opioids

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Nausea Show forest plot

2

107

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.32, 1.91]

1.1 Propacetamol vs opioids

2

107

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.32, 1.91]

2 Vomiting Show forest plot

2

107

Risk Ratio (M‐H, Fixed, 95% CI)

0.51 [0.10, 2.62]

2.1 Propacetamol vs opioids

2

107

Risk Ratio (M‐H, Fixed, 95% CI)

0.51 [0.10, 2.62]

3 Nausea/vomiting Show forest plot

1

30

Risk Ratio (M‐H, Fixed, 95% CI)

0.5 [0.15, 1.64]

3.1 Propacetamol vs opioids

1

30

Risk Ratio (M‐H, Fixed, 95% CI)

0.5 [0.15, 1.64]

4 Pruritus Show forest plot

2

107

Risk Ratio (M‐H, Fixed, 95% CI)

0.34 [0.10, 1.19]

4.1 Propacetamol vs opioids

2

107

Risk Ratio (M‐H, Fixed, 95% CI)

0.34 [0.10, 1.19]

5 GI disorders Show forest plot

2

91

Risk Ratio (M‐H, Fixed, 95% CI)

0.26 [0.10, 0.63]

5.1 Propacetamol vs opioids

2

91

Risk Ratio (M‐H, Fixed, 95% CI)

0.26 [0.10, 0.63]

6 Heart rate disorders Show forest plot

2

91

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.04, 3.03]

6.1 Propacetamol vs opioids

2

91

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.04, 3.03]
Figuras y tablas -
Comparison 18. Individual adverse events: propacetamol vs opioids
Ir a la tabla de la revisión