Appendix 1. CENTRAL search strategy

#1 MeSH descriptor Carcinoma, Basal Cell
#2 basal near cell near carcino*
#3 BCC
#4 MeSH descriptor Eyelid Neoplasms
#5 MeSH descriptor Orbital Neoplasms
#6 (#1 OR #2 OR #3 OR #4 OR #5)
#7 MeSH descriptor Mohs Surgery
#8 micrograph* or moh* near surg*
#9 MMS
#10 (#7 OR #8 OR #9)
#11 (#6 AND #10)

Appendix 2. MEDLINE (OvidSP) search strategy

1. randomized controlled trial.pt.
2. (randomized or randomised).ab,ti.
3. placebo.ab,ti.
4. dt.fs.
5. randomly.ab,ti.
6. trial.ab,ti.
7. groups.ab,ti.
8. or/1‐7
9. exp animals/
10. exp humans/
11. 9 not (9 and 10)
12. 8 not 11
13. exp carcinoma, basal cell/
14. (basal$ adj2 cell$ adj2 carcino$).tw.
15. BCC.tw.
16. exp eyelid neoplasms/
17. exp orbital neoplasms/
18. or/13‐17
19. exp mohs surgery/
20. ((micrograph$ or moh$) adj3 surg$).tw.
21. MMS.tw.
22. or/19‐21
23. 18 and 22
24. 12 and 23

The search filter for trials at the beginning of the MEDLINE strategy is from the published paper by Glanville (Glanville 2006).

Appendix 3. EMBASE (OvidSP) search strategy

1. exp randomized controlled trial/
2. exp randomization/
3. exp double blind procedure/
4. exp single blind procedure/
5. random$.tw.
6. or/1‐5
7. (animal or animal experiment).sh.
8. human.sh.
9. 7 and 8
10. 7 not 9
11. 6 not 10
12. exp clinical trial/
13. (clin$ adj3 trial$).tw.
14. ((singl$ or doubl$ or trebl$ or tripl$) adj3 (blind$ or mask$)).tw.
15. exp placebo/
16. placebo$.tw.
17. random$.tw.
18. exp experimental design/
19. exp crossover procedure/
20. exp control group/
21. exp latin square design/
22. or/12‐21
23. 22 not 10
24. 23 not 11
25. exp comparative study/
26. exp evaluation/
27. exp prospective study/
28. (control$ or prospectiv$ or volunteer$).tw.
29. or/25‐28
30. 29 not 10
31. 30 not (11 or 23)
32. 11 or 24 or 31
33. exp basal cell carcinoma/
34. (basal$ adj2 cell$ adj2 carcino$).tw.
35. BCC.tw.
36. exp eyelid tumor/
37. exp orbit tumor/
38. or/33‐37
39. exp chemosurgery/
40. ((micrograph$ or moh$) adj3 surg$).tw.
41. MMS.tw.
42. or/39‐41
43. 38 and 42
44. 32 and 43

Appendix 4. metaRegister of Controlled Trials search strategy

Mohs micrographic surgery

Appendix 5. ClinicalTrials.gov search strategy

Mohs Micrographic Surgery

Appendix 6. ICTRP search strategy

Mohs Micrographic Surgery