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Interventions musicales pour les patients ventilés mécaniquement

Appendices

Appendix 1. MEDLINE search strategy (OvidSP)

1 music/

2 music therapy/

3 (music$ or rhythm$ or melod$).tw.

4 (singing or sing or song$ or compos$ or improvis$).tw.

5 or/1‐4

6 Respiration artificial/

7 (artificial adj5 ventil$).tw.

8 (Ventilat$ adj5 mechanical).tw.

9 Intubation, intratracheal/

10 exp respiratory insufficiency/

11 (respiratory failure or (respiratory adj5 failure)).tw.

12 Suction/

13 or/6‐12

14 randomized controlled trial.pt.

15 controlled clinical trial.pt.

16 randomized controlled trial.sh.

17 random allocation.sh.

18 double blind method.sh.

19 single blind method.sh.

20 or/14‐19

21 (animals not human).sh.

22 20 not 21

23 clinical trial.pt.

24 exp clinical trial/

25 (clin$ adj25 trial$).ti,ab.

26 ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$)).ti,ab.

27 placebos.sh.

28 placebo$.ti,ab.

29 random$.ti,ab.

30 research design.sh.

31 or/23‐30

32 31 not 21

33 22 or 32

34 5 and 13

35 33 and 34

Appendix 2. PsycINFO search strategy (OvidSP)

1. empirical study.md. or followup study.md. or longitudinal study.md. or prospective study.md. or quantitative study.md. or treatment effectiveness evaluation/ or exp hypothesis testing/ or repeated measures/ or exp experimental design/ or placebo$.ti,ab. Or random$.ti,ab. Or (clin$ adj25 trial$).ti,ab. Or ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).ti,ab
2. artificial respiration/ or artificial near ventil$.tw. or Ventilat$ near mechanical.tw. or exp Trachea/ or intubation.tw. or respiratory failure.mp. or respiratory failure.tw. or suction.mp.
3. ( empirical study or followup study or longitudinal study or prospective study or quantitative study).md. or treatment effectiveness evaluation/ or exp hypothesis testing/ or repeated measures/ or exp experimental design/ or placebo$.ti,ab. or random$.ti,ab. or (clin$ adj25 trial$).ti,ab. or ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).ti,ab.
4. 1 and 2 and 3

Appendix 3. CENTRAL search strategy

#1 MeSH descriptor Music, this term only

#2 MeSH descriptor Music Therapy explode all trees

#3 music* or rhythm* or melod*

#4 singing or sing or song* or compos* or listening or improvis*

#5 (#1 OR #2 OR #3 OR #4)

#6 MeSH descriptor Respiration, Artificial, this term only

#7 artificial near ventil*

#8 Ventilat* near mechanical

#9  MeSH descriptor Intubation, Intratracheal, this term only

#10 MeSH descriptor Respiratory Insufficiency explode all trees

#11 (respiratory failure) or (respiratory near failure)

#12  MeSH descriptor Suction explode all trees

#13  (#6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12)

#14  (#5 AND #13)

Appendix 4. EMBASE search strategy (OvidSP)

1 exp MUSIC THERAPY/ or exp MUSIC/

2 (music$ or rhythm$ or melod$).tw.

3 (singing or sing or song$ or compos$ or listening or improvis$).tw.

4  or/1‐3

5  Respiration artificial/

6  (artificial adj10 ventilat$).mp. 

7  (Ventilat$ adj10 mechanical).tw.

8  exp Endotracheal Intubation/

9  exp Respiratory Failure/

10 respiratory failure.mp. or (respiratory adj10 failure).tw.

11  Suction.mp. or SUCTION/

12  or/5‐11

13   4 and 12

14  Randomized Controlled Trial/

15  RANDOMIZATION/

16  Controlled Study/

17  Multicenter Study/

18   Phase 3 Clinical Trial/

19   Phase 4 Clinical Trial/

20   Double Blind Procedure/

21   Single Blind Procedure/

22   (RANDOM* or CROSS?OVER* or FACTORIAL* or PLACEBO* or VOLUNTEER*).ti,ab.

23   ((SINGL* or DOUBL* or TREBL* or TRIPL*) adj5 (BLIND* or MASK*)).ti,ab.

24   or/14‐23

25  HUMAN.sh,hw.

26   25 and 24

27   26 and 13

Appendix 5. CINAHL search strategy (EBSCOhost)

S1 TX compos* or TX singing or TX sing or TX song* or TX music* or TX rhythm* or TX melod* or MH music or MH music therapy 
S2 (MH "Intubation, Intratracheal") or (MH "Extubation") or (MH "Suction") or (MH "Suctioning, Endotracheal") or (MH "Airway Suctioning") or TX ventilator N5 weaning or TX respiratory N5 failure or (respiratory failure) or (MH "Respiratory Failure") or (MH "Ventilator Weaning") or TX Ventilat* N5 mechanical or TX artificial N5 ventil* or respiratory insufficiency or (artificial respiration) or (MH "Ventilation, Mechanical+") or (MH "Ventilators, Mechanical") 
S3 (S1 and S2) not animal*

Appendix 6. LILACS search strategy (Virtual Health Library))

(music$) and ((mechanical and ventilation) or (intratracheal and intubation) or (respiratory and failure) or "RESPIRATORY FAILURE" or (artificial and respiration) or (suction) or ("SUCTION" ))

Appendix 7. AMED search strategy (OvidSP)

Searches

1

Music/

2

Music Therapy/

3

(music$ or rhythm$ or melod$).tw.

4

(singing or sing or song$ or compos$ or listening or improvis$).tw.

5

or/1‐4

6

Respiration artificial/

7

artificial near ventil$.tw.

8

Ventilat$ near mechanical.tw.

9

exp respiratory insufficiency/

10

respiratory failure.mp. or respiratory near failure.tw. [mp=abstract, heading words, title]

11

exp Intubation/

12

or/6‐11

13

5 and 12

Appendix 8. ISI Web of Science search strategy

#1 TS=(Respiration artificial) or TS=(artificial SAME ventil*) or TS=(Ventilat* SAME mechanical) or TS=(Intubation SAME intratracheal) or TS=(respiratory insufficiency) or TS=(respiratory SAME failure)
#2 TS=music* or TS=(music therapy) or TS=(singing or song or song* or compos* or improvis* or rhythm* or melod*) or TS=(suction)
#3 TS=(control$ or prospectiv$ or volunteer$) or TS=(prospective studies) or TS=(follow up studies) or TS=(evaluation studies) or TS=(comparative study) or TS=random$ or TS=placebo$ or TS=(Clinical trial$) or TS=(single‐blind method$) or TS=(double blind method$) or TS=(randomized controlled trial$) or TS=(controlled clinical trial$) or TS=(random allocation)
#4 #1 and #2 and #3

Appendix 9. The specialist music therapy research database search strategy

Research database is no longer functional. Archives of research reports, dissertations and conference proceedings were handsearched.

Appendix 10. CAIRSS for Music search strategy (Webvoyage)

("mechanical ventilation")[in Keyword Anywhere] OR ("artificial ventilation")[in Keyword Anywhere] OR 

("artificial respiration")[in Keyword Anywhere]

(intubation)[in Keyword Anywhere] OR ("suction")[in Keyword Anywhere]

("respiratory failure" [in Keyword Anywhere] OR ("respiratory insufficiency")[in Keyword Anywhere]

Appendix 11. Proquest Digital Dissertations search strategy (Proquest)

((artificial ) W/3 (respir*)) AND ((Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*))

((artificial ) W/3 (ventilation)) AND ((Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*))

((mechanical) W/3 (ventilation)) AND ((Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*))

((intubation or suction)) AND ((Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*))

((respirat*) w/3 (insufficien*)) AND ((Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*))

((respirat*) w/3 (failure*)) AND ((Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*))

 

Appendix 12. Clinical trials.gov search strategy

(music or "music therapy")

Appendix 13. Current Controlled Trials search strategy

music

music therapy

Appendix 14. National Research Registry search strategy

music

Appendix 15. NIH CRISP search strategy

music

Appendix 16. Search strategy 2014

Medline search strategy (OvidSP)

1

music/

2

music therapy/

3

(music$ or rhythm$ or melod$).tw.

4

(singing or sing or song$ or compos$ or improvis$).tw.

5

or/1‐4

6

Respiration artificial/

7

(artificial adj5 ventil$).tw.

8

(Ventilat$ adj5 mechanical).tw.

9

Intubation, intratracheal/

10

exp respiratory insufficiency/

11

(respiratory failure or (respiratory adj5 failure)).tw.

12

Suction/

13

or/6‐12

14

randomized controlled trial.pt.

15

controlled clinical trial.pt.

16

randomized.ab.

17

placebo.ab.

18

drug therapy.fs.

19

randomly.ab.

20

trial.ab.

21

groups.ab.

22

or/14‐21

23

exp animals/ not humans.sh.

24

22 not 23

25

5 and 13 and 24

26

limit 25 to yr="2010 ‐ 2014"

PsycINFO search strategy (EBSCOhost)

S1 DE music

S2 DE (music therapy)

S3 TX (music* or rhythm* or melod* or singing or sing or song* or compos* or listening or improvis*)

S4 S1 OR S2 OR S3

S5 DE "Artificial Respiration"

S6 TX (artificial N5 ventil*)

S7 TX (Ventilat* N5 mechanical)

S8 DE "Trachea"

S9 TX intubation

S10 TX (respiratory failure)

S11 TX (suction*)

S12 S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11

S13 MR ((empirical study) or (followup study) or (longitudinal study) or (prospective study) or (clinical trial))

S14 DE "Treatment Effectiveness Evaluation"

S15 DE "Experimental Design" OR DE "Between Groups Design" OR DE "Clinical Trials" OR DE "Cohort

Analysis" OR DE "Followup Studies" OR DE "Hypothesis Testing" OR DE "Longitudinal Studies" OR DE "Repeated Measures" OR DE "Between Groups Design"

S16 TI(placebo* or random* or randomized* or trial or groups)

S17 AB(placebo* or random* or randomized* or trial or groups)

S18 AB(placebo* or random* or randomized* or trial or groups)

S19 S13 OR S14 OR S15 OR S16 OR S17 OR S18

S20 S4 AND S12 AND S19

S21 S20 Limiters – Publication Year: 2010‐2013

CENTRAL search strategy

#1 MeSH descriptor Music, this term only

#2 MeSH descriptor Music Therapy explode all trees

#3 music* or rhythm* or melod*

#4 singing or sing or song* or compos* or listening or improvis*

#5 (#1 OR #2 OR #3 OR #4)

#6 MeSH descriptor Respiration, Artificial, this term only

#7 artificial near ventil*

#8 Ventilat* near mechanical

#9 MeSH descriptor Intubation, Intratracheal, this term only

#10 MeSH descriptor Respiratory Insufficiency explode all trees

#11 (respiratory failure) or (respiratory near failure)

#12 MeSH descriptor Suction explode all trees

#13 (#6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12)

#14 (#5 AND #13) (limit record entry: 2010‐2014; in trials only)

EMBASE search strategy (Emtree)

#1 'music therapy'/exp

#2 music* OR rhythm* OR melod*

#3 singing OR song* OR listening OR improvis*

#4 #1 OR #2 OR #3

#5 'artificial ventilation'/de

#6 artificial NEAR/10 ventilat*

#7 ventilat* NEAR/10 mechanical

#8 'endotracheal intubation'/exp

#9 'respiratory failure'/exp

#10 respiratory NEAR/10 failure

#11 'airway suction'

#12 #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11

#13 'randomized controlled trial'/exp

#14 'controlled clinical trial'/exp

#15 randomized:ab

#16 randomly:ab

#17 trial:ab

#18 groups:ab

#19 #13 OR #14 OR #15 OR #16 OR #17 OR #18

#20 'human'/exp

#21 #19 AND #20

#22 #4 AND #12 AND #21

#23 #22 AND (2010:py OR 2011:py OR 2012:py OR 2013:py OR 2014:py)

CINAHL search strategy (EBSCOhost)

S1 TX compos* or TX singing or TX sing or TX song* or TX music* or TX rhythm* or TX melod* or MH music or MH music therapy
S2 (MH "Intubation, Intratracheal") or (MH "Extubation") or (MH "Suction") or (MH "Suctioning, Endotracheal") or (MH "Airway Suctioning") or TX ventilator N5 weaning or TX respiratory N5 failure or (respiratory failure) or (MH "Respiratory Failure") or (MH "Ventilator Weaning") or TX Ventilat* N5 mechanical or TX artificial N5 ventil* or respiratory insufficiency or (artificial respiration) or (MH "Ventilation, Mechanical+") or (MH "Ventilators, Mechanical")
S3 (S1 and S2) not animal* (limit 20100101‐20141231)

LILACS search strategy (Virtual Health Library)

(music$) and ((mechanical and ventilation) or (intratracheal and intubation) or (respiratory and failure) or "RESPIRATORY FAILURE" or (artificial and respiration) or (suction) or "SUCTION" )

(this database does not have the capacity to apply date limits. Results outputs were reviewed from 2008 onward)

ISI Web of Science search strategy

#1 TS=(Respiration artificial) or TS=(artificial SAME ventil*) or TS=(Ventilat* SAME mechanical) or TS=(Intubation SAME intratracheal) or TS=(respiratory insufficiency) or TS=(respiratory SAME failure)
#2 TS=music* or TS=(music therapy) or TS=(singing or song or song* or compos* or improvis* or rhythm* or melod*) or TS=(suction)
#3 TS=(control$ or prospectiv$ or volunteer$) or TS=(prospective studies) or TS=(follow up studies) or TS=(evaluation studies) or TS=(comparative study) or TS=random$ or TS=placebo$ or TS=(Clinical trial$) or TS=(single‐blind method$) or TS=(double blind method$) or TS=(randomized controlled trial$) or TS=(controlled clinical trial$) or TS=(random allocation)
#4 #1 and #2 and #3

#5 Timespan = 2010‐2014

CAIRSS for Music search strategy (Webvoyage)

("mechanical ventilation")[in Keyword Anywhere] OR ("artificial ventilation")[in Keyword Anywhere] OR

("artificial respiration")[in Keyword Anywhere]

(intubation)[in Keyword Anywhere] OR ("suction")[in Keyword Anywhere]

("respiratory failure" [in Keyword Anywhere] OR ("respiratory insufficiency")[in Keyword Anywhere]

Proquest Digital Dissertations search strategy (Proquest)

ab(mechanical* ventilat*) AND ab(Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*)

ab(artificial* respirat*) AND ab(Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*)

ab(articicial* ventilat*) AND ab(Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*)

ab(intubation or suction) AND ab(Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*)

ab(respirat* insufficien*) AND ab(Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*)

ab(respirat* failure) AND ab(Singing or sing or song* or compos* or improvis* or music* or rhythm* or melod*)

Clinical trials.gov search strategy

(music or "music therapy") (limits by date first received: 01/01/2010 ‐ 03/24/2014)

Current Controlled Trials search strategy

music

music therapy

National Research Registry search strategy

music

NIH CRISP search strategy

music

Study Flow Diagram ‐ Original Review.
Figuras y tablas -
Figure 1

Study Flow Diagram ‐ Original Review.

Study flow diagram ‐ updated review.
Figuras y tablas -
Figure 2

Study flow diagram ‐ updated review.

Funnel plot of comparison: 1 Music versus standard care, outcome: 1.4 Respiratory rate.
Figuras y tablas -
Figure 3

Funnel plot of comparison: 1 Music versus standard care, outcome: 1.4 Respiratory rate.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 4

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 5

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Comparison 1 Music versus standard care, Outcome 1 State Anxiety (change scores).
Figuras y tablas -
Analysis 1.1

Comparison 1 Music versus standard care, Outcome 1 State Anxiety (change scores).

Comparison 1 Music versus standard care, Outcome 2 Heart Rate.
Figuras y tablas -
Analysis 1.2

Comparison 1 Music versus standard care, Outcome 2 Heart Rate.

Comparison 1 Music versus standard care, Outcome 3 Heart Rate (adequate randomization).
Figuras y tablas -
Analysis 1.3

Comparison 1 Music versus standard care, Outcome 3 Heart Rate (adequate randomization).

Comparison 1 Music versus standard care, Outcome 4 Respiratory Rate.
Figuras y tablas -
Analysis 1.4

Comparison 1 Music versus standard care, Outcome 4 Respiratory Rate.

Comparison 1 Music versus standard care, Outcome 5 Respiratory Rate (adequate randomization).
Figuras y tablas -
Analysis 1.5

Comparison 1 Music versus standard care, Outcome 5 Respiratory Rate (adequate randomization).

Comparison 1 Music versus standard care, Outcome 6 Systolic Blood Pressure.
Figuras y tablas -
Analysis 1.6

Comparison 1 Music versus standard care, Outcome 6 Systolic Blood Pressure.

Comparison 1 Music versus standard care, Outcome 7 Diastolic Blood Pressure.
Figuras y tablas -
Analysis 1.7

Comparison 1 Music versus standard care, Outcome 7 Diastolic Blood Pressure.

Comparison 1 Music versus standard care, Outcome 8 Mean Arterial Pressure.
Figuras y tablas -
Analysis 1.8

Comparison 1 Music versus standard care, Outcome 8 Mean Arterial Pressure.

Comparison 1 Music versus standard care, Outcome 9 Oxygen Saturation Level (change scores).
Figuras y tablas -
Analysis 1.9

Comparison 1 Music versus standard care, Outcome 9 Oxygen Saturation Level (change scores).

Comparison 1 Music versus standard care, Outcome 10 Mortality.
Figuras y tablas -
Analysis 1.10

Comparison 1 Music versus standard care, Outcome 10 Mortality.

Summary of findings for the main comparison. Music compared to standard care for mechanically ventilated patients

Music compared to standard care for mechanically ventilated patients

Patient or population: mechanically ventilated patients
Settings: intensive care units
Intervention: music
Comparison: standard care

Outcomes

Relative effect
(95% CI)

No of participants
(studies)

Quality of the evidence
(GRADE)

State anxiety
STAI, VAS

The mean state anxiety in the intervention groups was
1.11 standard deviations lower
(1.75 to 0.47 lower)

288
(5 studies)

⊕⊕⊝⊝
low1,2,3,4

Heart rate
beats per minute

The mean heart rate in the intervention groups was
3.95 lower
(6.62 to 1.27 lower)

338
(8 studies)

⊕⊝⊝⊝
very low1,5,6

Respiratory rate
breaths per minute

The mean respiratory rate in the intervention groups was
2.87 lower
(3.64 to 2.10 lower)

357
(9 studies)

⊕⊝⊝⊝
very low1,6

Systolic blood pressure

mmHg

The mean systolic blood pressure in the intervention groups was
4.22 lower
(6.38 to 2.06 lower)

269
(6 studies)

⊕⊝⊝⊝
very low1,7

Diastolic blood pressure

mmHg

The mean diastolic blood pressure in the intervention groups was
2.16 lower
(4.4 lower to 0.07 higher)

269
(6 studies)

⊕⊝⊝⊝
very low1,7

Mean arterial pressure

mmHg

The mean arterial pressure in the intervention groups was
1.79 lower
(4.56 lower to 0.99 higher)

98
(3 studies)

⊕⊝⊝⊝
very low1,7

Oxygen saturation level

The mean oxygen saturation level in the intervention groups was
0.05 lower
(0.67 lower to 0.57 higher)

193
(4 studies)

⊕⊕⊝⊝
low1

CI: Confidence interval

GRADE Working Group grades of evidence
High quality: further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: we are very uncertain about the estimate.

1 The majority of the trials were assessed as high risk of bias studies
2 All point estimates favour music although the magnitude of the effect differs across studies
3 Wide confidence interval, however, this is due to the fact that some studies reported very large beneficial effects of music on anxiety
4 Large reduction in anxiety as evidenced by SMD of 1.11
5 Results were inconsistent across studies as evidenced by I² = 62%
6 Somewhat wide confidence interval
7 Wide confidence interval

Figuras y tablas -
Summary of findings for the main comparison. Music compared to standard care for mechanically ventilated patients
Comparison 1. Music versus standard care

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 State Anxiety (change scores) Show forest plot

5

288

Std. Mean Difference (IV, Random, 95% CI)

‐1.11 [‐1.75, ‐0.47]

2 Heart Rate Show forest plot

8

338

Mean Difference (IV, Random, 95% CI)

‐3.95 [‐6.62, ‐1.27]

2.1 Final score

2

63

Mean Difference (IV, Random, 95% CI)

‐5.26 [‐13.56, 3.03]

2.2 Change score

6

275

Mean Difference (IV, Random, 95% CI)

‐3.82 [‐6.83, ‐0.82]

3 Heart Rate (adequate randomization) Show forest plot

7

318

Mean Difference (IV, Random, 95% CI)

‐4.01 [‐6.80, ‐1.22]

4 Respiratory Rate Show forest plot

9

357

Mean Difference (IV, Random, 95% CI)

‐2.87 [‐3.64, ‐2.10]

4.1 Final score

3

83

Mean Difference (IV, Random, 95% CI)

‐2.14 [‐4.06, ‐0.22]

4.2 Change score

6

274

Mean Difference (IV, Random, 95% CI)

‐3.01 [‐3.85, ‐2.17]

5 Respiratory Rate (adequate randomization) Show forest plot

8

337

Mean Difference (IV, Random, 95% CI)

‐2.87 [‐3.64, ‐2.09]

6 Systolic Blood Pressure Show forest plot

6

269

Mean Difference (IV, Random, 95% CI)

‐4.22 [‐6.38, ‐2.06]

6.1 Final score

1

14

Mean Difference (IV, Random, 95% CI)

‐9.0 [‐22.40, 4.40]

6.2 Change score

5

255

Mean Difference (IV, Random, 95% CI)

‐4.09 [‐6.28, ‐1.90]

7 Diastolic Blood Pressure Show forest plot

6

269

Mean Difference (IV, Random, 95% CI)

‐2.16 [‐4.40, 0.07]

7.1 Final score

1

14

Mean Difference (IV, Random, 95% CI)

‐3.70 [‐15.17, 7.77]

7.2 Change score

5

255

Mean Difference (IV, Random, 95% CI)

‐2.13 [‐4.58, 0.31]

8 Mean Arterial Pressure Show forest plot

3

98

Mean Difference (IV, Random, 95% CI)

‐1.79 [‐4.56, 0.99]

8.1 Final score

1

20

Mean Difference (IV, Random, 95% CI)

‐4.75 [‐17.81, 8.31]

8.2 Change score

2

78

Mean Difference (IV, Random, 95% CI)

‐1.65 [‐4.49, 1.20]

9 Oxygen Saturation Level (change scores) Show forest plot

4

193

Mean Difference (IV, Random, 95% CI)

‐0.05 [‐0.67, 0.57]

10 Mortality Show forest plot

2

271

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.38, 1.51]

Figuras y tablas -
Comparison 1. Music versus standard care