Fetal fibronectin testing for reducing the risk of preterm birth

Vincenzo Berghella; Edward Hayes; John Visintine; Jason K Baxter

doi:10.1002/14651858.CD006843.pub2

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Analysis 1.1

Comparison 1 Comparison 01 FFN knowledge versus no knowledge, Outcome 01 Preterm birth < 37 week, Outcome 1 Outcome 01 Preterm birth < 37 weeks.

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Analysis 2.1

Comparison 2 Comparison 01 FFN knowledge versus no knowledge, Outcome 02 Preterm birth < 34 week, Outcome 1 Outcome 02 Preterm birth < 34 week.

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Analysis 3.1

Comparison 3 Comparison 01 FFN knowledge versus no knowledge, Outcome 03 Preterm birth < 32 week, Outcome 1 Outcome 03 Preterm birth < 32 week.

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Analysis 4.1

Comparison 4 Comparison 01 FFN knowledge versus no knowledge, Outcome 04 Preterm birth < 28 week, Outcome 1 Outcome 04 Preterm birth < 28 week.

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Analysis 5.1

Comparison 5 Comparison 01 FFN knowledge versus no knowledge, Outcome 05 Gestational age at delivery (weeks), Outcome 1 Outcome 05 Gestational age at delivery.

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Analysis 6.1

Comparison 6 Comparison 01 FFN knowledge versus no knowledge, Outcome 06 Birthweight 2500 grams, Outcome 1 Outcome 06 Birthweight < 2500 g.

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Analysis 7.1

Comparison 7 Comparison 01 FFN knowledge versus no knowledge, Outcome 07 Perinatal death, Outcome 1 Outcome 07 Perinatal death.

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Analysis 8.1

Comparison 8 Comparison 01 FFN knowledge versus no knowledge, Outcome 08 Maternal hospitalization, Outcome 1 Outcome 08 Maternal hospitalization.

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Analysis 9.1

Comparison 9 Comparison 01 FFN knowledge versus no knowledge, Outcome 09 Tocolysis, Outcome 1 Outcome 09 Tocolysis.

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Analysis 10.1

Comparison 10 Comparison 01 FFN knowledge versus no knowledge, Outcome 10 Steroids for fetal lung maturity, Outcome 1 Outcome 10 Steroids for Fetal Lung Maturity.

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Analysis 11.1

Comparison 11 Comparison 01 FFN knowledge versus no knowledge, Outcome 11 Time to evaluate (hours), Outcome 1 Outcome 11 Time to evaluate.

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Comparison 1. Comparison 01 FFN knowledge versus no knowledge, Outcome 01 Preterm birth < 37 week

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 01 Preterm birth < 37 weeks Show forest plot	3	275	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.34, 0.87]

Comparison 1. Comparison 01 FFN knowledge versus no knowledge, Outcome 01 Preterm birth < 37 week

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Comparison 2. Comparison 01 FFN knowledge versus no knowledge, Outcome 02 Preterm birth < 34 week

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 02 Preterm birth < 34 week Show forest plot	3	281	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.41, 2.47]

Comparison 2. Comparison 01 FFN knowledge versus no knowledge, Outcome 02 Preterm birth < 34 week

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Comparison 3. Comparison 01 FFN knowledge versus no knowledge, Outcome 03 Preterm birth < 32 week

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 03 Preterm birth < 32 week Show forest plot	3	282	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.28, 2.58]

Comparison 3. Comparison 01 FFN knowledge versus no knowledge, Outcome 03 Preterm birth < 32 week

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Comparison 4. Comparison 01 FFN knowledge versus no knowledge, Outcome 04 Preterm birth < 28 week

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 04 Preterm birth < 28 week Show forest plot	3	284	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.15, 6.82]

Comparison 4. Comparison 01 FFN knowledge versus no knowledge, Outcome 04 Preterm birth < 28 week

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Comparison 5. Comparison 01 FFN knowledge versus no knowledge, Outcome 05 Gestational age at delivery (weeks)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 05 Gestational age at delivery Show forest plot	3	288	Mean Difference (IV, Fixed, 95% CI)	0.29 [‐0.35, 0.93]

Comparison 5. Comparison 01 FFN knowledge versus no knowledge, Outcome 05 Gestational age at delivery (weeks)

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Comparison 6. Comparison 01 FFN knowledge versus no knowledge, Outcome 06 Birthweight 2500 grams

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 06 Birthweight < 2500 g Show forest plot	1	70	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.21, 2.44]

Comparison 6. Comparison 01 FFN knowledge versus no knowledge, Outcome 06 Birthweight 2500 grams

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Comparison 7. Comparison 01 FFN knowledge versus no knowledge, Outcome 07 Perinatal death

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 07 Perinatal death Show forest plot	1	97	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]

Comparison 7. Comparison 01 FFN knowledge versus no knowledge, Outcome 07 Perinatal death

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Comparison 8. Comparison 01 FFN knowledge versus no knowledge, Outcome 08 Maternal hospitalization

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 08 Maternal hospitalization Show forest plot	3	290	Risk Ratio (M‐H, Fixed, 95% CI)	1.36 [0.90, 2.07]

Comparison 8. Comparison 01 FFN knowledge versus no knowledge, Outcome 08 Maternal hospitalization

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Comparison 9. Comparison 01 FFN knowledge versus no knowledge, Outcome 09 Tocolysis

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 09 Tocolysis Show forest plot	4	350	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.78, 1.30]

Comparison 9. Comparison 01 FFN knowledge versus no knowledge, Outcome 09 Tocolysis

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Comparison 10. Comparison 01 FFN knowledge versus no knowledge, Outcome 10 Steroids for fetal lung maturity

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 10 Steroids for Fetal Lung Maturity Show forest plot	3	270	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.85, 1.79]

Comparison 10. Comparison 01 FFN knowledge versus no knowledge, Outcome 10 Steroids for fetal lung maturity

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Comparison 11. Comparison 01 FFN knowledge versus no knowledge, Outcome 11 Time to evaluate (hours)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Outcome 11 Time to evaluate Show forest plot	3	234	Mean Difference (IV, Fixed, 95% CI)	0.04 [‐0.39, 0.47]

Comparison 11. Comparison 01 FFN knowledge versus no knowledge, Outcome 11 Time to evaluate (hours)

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