| Type of trials | Number of trials | Herbs in regimen of IP | Medicine (herbs or western medicine) in CP | Route of administration of IP | Peroid of administration of IP | RCT and blind method | Follow time |
| type I | Huang 2003 | Zhixue Capsule (Cortex Fictamni Radicis, Radix Sphporae Flavescentis, there's no specific dosage due to commercial secret) | Zhikang Tablet (there's no specific dosage and herbs due to commercial secret) | oral ad | 7 days | RCT with double blind | No |
| type I | Lu 2005 | Fuhuang Tablet (Radix ET Rhizoma Rhei, Radix Sanguisorbae, Fructus Sophorae, Pollen Typhae, there's no specific dosage due to commercial secret) | Zhining Tablet (Radix Sanguisorbae, Cacumen Biotae, Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Scutellariae, Flos Sophorae Immaturus, there's no specific dosage due to commercial secret) | oral ad | 7 days | RCT with single blind | No |
| type I | Zheng 2005 | Zhixueningheji (Zhixueheji) (Radix Sanguisorbae, Cacumen Biotae, Cortex Phellodendri, Radix Scutellariae, Prepared Radix Rehmanniae, there's no specific dosage due to commercial secret) | Huaijiao Pill (Radix Sanguisorbae, Radix Sanguisorbae,Radix Scutellariae, there's no specific dosage due to commercial secret) | oral ad | 7 days | RCT without blind | No |
| type I | He 2006 | Zhixue Capsule (Cortex Fictamni Radicis, Radix Sphporae Flavescentis, there's no specific dosage due to commercial secret) | Huaijiao Pill (Radix Sanguisorbae, Radix Sanguisorbae,Radix Scutellariae, there's no specific dosage due to commercial secret) | oral ad | 7 days | RCT without blind | No |
| type I | Zhang 2008 | Zhixueheji (Radix Sanguisorbae, Cacumen Biotae, Cortex Phellodendri, Radix Scutellariae, Prepared Radix Rehmanniae, there's no specific dosage due to commercial secret) | Zhichuang Tablet (there's no specific dosage and herbs due to commercial secret) | oral ad | 30‐45 days | RCT without blind | No |
| type II | Zheng 1999 | Zhixuening Decoction (Radix Sanguisorbae, Radix Astragali sue Hedysari, Herba Schizonepetae, Fresh Radix Rehmanniae, Radix Scutellariae, OS Sepiella seu Sepiae, Radix Boehmeriae, Rhizome Cimicifugae, Radix Angelicae Dahuricae, Radix Paeoniae Alba, Fructus Cannabis, Semen Pruni, there's no specific dosage due to commercial secret) | adrenosem 10mg, vit K4 8mg | oral ad | 7 days | RCT without blind | No |
| type II | Chen 2002 | Zhixuekang Decoction (Fructus Cannabis 15g, Semen Pruni 15g, Prepared Radix Rehmanniae 20g, Rhizoma Bletillae 3g, Radix Sanguisorbae 30g, Herba Ecliptae 30g, Radix Codonopsis Pilosulae 30g, Radix Astragali seu Hedysari 30g, Radix Angelicae Sinensis 10g, Rhizoma Coptidis 10g, Flos Lonicerae 20g, Colla Corii Asini 15g, Flos Sophorae 30g, Radix Scrophulariae 20g, Herba Agrimoniae 30g, Fructus Mori 20g, Radix Glycyrrhizae 10g) | adrenosem 10mg, vit K4 4mg, norfloxacin 0.2 | oral ad | 10 days | RCT without blind | No |
| type II | Peng 2004 | Callicarpa Nudiflora Tablet (there's no specific dosage due to commercial secret) | adrenosem, vit C (without specific dosage) | oral ad | 14 days | RCT without blind | 2‐6 months |
| type II | Xu 2004 | Subgroup1: blood‐heat (Cacumen Biotae, Radix Sanguisorbae, Fresh Radix Rehmanniae, Cortex Moutan Radicis, Radix Paeonize Rubra, Radix ET Rhizoma Rhei, Flos Sophorae, Rhizoma Coptidis, Radix Scutellariae, Herba Schizonepetae, Radix Glycyrrhizae) Subgroup 2: damp‐heat (Rhizoma Coptidis, Radix Glycyrrhizae, Radix Sanguisorbae, Radix ET Rhizoma Rhei, Radix Angelicae Sinensis, Cortex Phellodendri, Rhizoma Atractylodis, Radix Ledebouriellae, Flos Sophorae, Radix Gentianae Macrophyllae, Semen Persicae, Rhizoma Alismatis, Radix Rubiae, Gleditsia sinensis Lam) Subgroup 3: deficiency of blood (Radix Paeonize Rubra, Radix Angelicae Sinensis, Radix Sanguisorbae, Cacumen Biotae, Flos Sophorae, Colla Corri Asini, Raidx Codonopsisi Pilosulae, Rhizoma Atractylodis Macrocephalae, Smilax China L, Prepared Radix Rehmanniae, Radix Astragali seu Hedysari, Rhizoma Ligustici Chuanxiong) There is no specific dosage due to commercial secret | adrenosem, cefradine (without specific dosage) | oral ad | 5 days | RCT without blind | No |
