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Cochrane Database of Systematic Reviews

Efecto del tratamiento precoz con fármacos hipotensores sobre la mortalidad a corto y largo plazo en pacientes con un cuadro cardiovascular agudo

Información

DOI:
https://doi.org/10.1002/14651858.CD006743.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 07 octubre 2009see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Hipertensión

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Marco I Perez

    Correspondencia a: Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada

    [email protected]

  • Vijaya M Musini

    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada

  • James M Wright

    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada

Contributions of authors

Marco Perez formulated the idea for the review, and developed the basis for the protocol. He took the lead roles in searching, identifying and assessing studies, in data extraction and in writing up the review.

Vijaya Musini is an independent reviewer. She helped with the methodology of the review and independently checked the data extraction.

James Wright also acted as an independent reviewer with the extraction and discussion of the included and excluded trials as well as with contributing with the final draft of this review.

Sources of support

Internal sources

  • Department of Anesthesiology, Pharmacology & Therapeutics, Universitiy of British Columbia, Canada.

External sources

  • CIHR, Canada.

    Salary support

Declarations of interest

None.

Acknowledgements

We are in deep gratitude to the trialists who provided us with additional information from their studies. Specially to Eugenio Santoro, from the GISSI‐3 trial, who kindly responded to all of our requests. We acknowledge the assistance provided by the Cochrane Hypertension Review Group, particularly Stephen Adams for his unconditional help in retrieving all studies. We are grateful to Ken Basset, Thomas Perry, Benji Heran, Jenny Chen and Gavin Wong for their comments on the draft.

Version history

Published

Title

Stage

Authors

Version

2009 Oct 07

Effect of early treatment with anti‐hypertensive drugs on short and long‐term mortality in patients with an acute cardiovascular event

Review

Marco I Perez, Vijaya M Musini, James M Wright

https://doi.org/10.1002/14651858.CD006743.pub2

2009 Jul 08

Effect of early treatment with anti‐hypertensive drugs on short and long‐term health outcomes in patients with an acute cardiovascular event

Protocol

Marco I Perez, Vijaya M Musini, James M Wright

https://doi.org/10.1002/14651858.CD006743

Differences between protocol and review

Changes from the protocol to the review:

Title

  • The term "health outcomes" was changed to a more specific term "Mortality"

Objectives

  • From "early treatment" changed to more specific terms "immediate and short‐term treatment"

  • From "short‐term and long‐term health outcomes" to more specific  terms "mortality at 2,10 and ≥ 30 days"

  • Regarding BP and HR changes from "during time the drug is being administrated" to more specific terms "during the first 24 hours of treatment"

Types of studies

  • From "RCT must provide at least one of primary outcome measures" to more specific terms "must provide mortality data at least one of the specified time periods, 2 days, 10 days or ≥ 30 days"

Types of participants

  • Hypertensive encephalopathy and acute renal failure were no longer included as part of the scope of this review. It was assessed that the former had already been addressed in our previous review of hypertensive emergency review. Since acute renal failure is not considered as an acute cardiovascular event according to ICD‐10 (N17‐19), we wanted to avoid ambiguities.

Types of interventions:

  • "early treatment" change to  more specific terms "immediate and short‐term treatments"

Types of outcomes:

  • From "all cause mortality" changed to more specific terms "all cause mortality at 2, 10 and  ≥ 30 days".

  • Non‐fatal serious adverse events were change from a primary outcome to be a secondary outcome due to a critic that there should be only one primary outcome

  • Regarding BP and HR changes "during treatment" to more specific terms "during first 24 hours of treatment"