Low molecular weight heparin for prevention of venous thromboembolism in patients with lower‐leg immobilization

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Ir a:

Analysis 1.1

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 1 DVT: irrespective of type of plaster, whether operated or not.

Analysis 1.2

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 2 DVT: in below‐knee cast, whether operated or not.

Analysis 1.3

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 3 PE.

Analysis 1.4

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 4 DVT: only non‐operated patients.

Analysis 1.5

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 5 DVT: operated patients.

$Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 6 DVT: fractures.$

Analysis 1.6

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 6 DVT: fractures.

Analysis 1.7

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 7 DVT: soft‐tissue injuries.

Analysis 1.8

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 8 DVT: distal segment.

Analysis 1.9

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 9 DVT: proximal segment.

Analysis 1.10

Comparison 1 Low molecular weight heparin versus no prophylaxis/placebo, Outcome 10 Symptomatic VTE.

Comparison 1. Low molecular weight heparin versus no prophylaxis/placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 DVT: irrespective of type of plaster, whether operated or not Show forest plot	6	1490	Odds Ratio (M‐H, Random, 95% CI)	0.49 [0.34, 0.72]

2 DVT: in below‐knee cast, whether operated or not Show forest plot	5	894	Odds Ratio (M‐H, Fixed, 95% CI)	0.54 [0.37, 0.80]

3 PE Show forest plot	3	896	Odds Ratio (M‐H, Fixed, 95% CI)	0.20 [0.01, 4.23]

4 DVT: only non‐operated patients Show forest plot	4	788	Odds Ratio (M‐H, Fixed, 95% CI)	0.35 [0.19, 0.62]

5 DVT: operated patients Show forest plot	4	699	Odds Ratio (M‐H, Fixed, 95% CI)	0.54 [0.37, 0.80]

6 DVT: fractures Show forest plot	5	817	Odds Ratio (M‐H, Fixed, 95% CI)	0.53 [0.36, 0.78]

7 DVT: soft‐tissue injuries Show forest plot	5	658	Odds Ratio (M‐H, Fixed, 95% CI)	0.39 [0.22, 0.68]

8 DVT: distal segment Show forest plot	5	1208	Odds Ratio (M‐H, Fixed, 95% CI)	0.61 [0.42, 0.89]

9 DVT: proximal segment Show forest plot	5	1217	Odds Ratio (M‐H, Fixed, 95% CI)	0.41 [0.19, 0.91]

10 Symptomatic VTE Show forest plot	4	1303	Odds Ratio (M‐H, Fixed, 95% CI)	0.16 [0.05, 0.56]

Comparison 1. Low molecular weight heparin versus no prophylaxis/placebo