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Diagnóstico viral rápido para la enfermedad respiratoria febril aguda en niños que son atendidos en el servicio de urgencias

Appendices

Appendix 1. Previous search strategy

For the original 2009 review we searched the Cochrane Central register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 1); MEDLINE (1950 to April Week 3 2009); EMBASE (1988 to Week 16, 2009); MEDLINE In‐Process & Other Non‐Indexed Citations (April 27, 2009); HealthStar (1966 to 2009); BIOSIS Previews (1969 to 2009); CAB Abstracts (1973 to 2007); CBCA Reference (1970 to 2007); and ProQuest Dissertations and Theses – Full Text (1861 to 2009).

Search terms were adapted to accommodate the controlled vocabulary and search language for each electronic resource. In MEDLINE, these search terms were combined with the highly sensitive search strategy for identifying RCTs (Lefebvre 2008). The filter was modified for use in MEDLINE In‐Process & Other Non‐Indexed Citations, EMBASE, and HealthStar. All search strategies included pediatric terms to restrict to pediatric studies. No language or date restrictions were applied to the search strategies. See search details below.

We updated the review in 2011 using an updated search of the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4; www.thecochranelibrary.com, accessed 9 December 2011), which contains the Cochrane ARI Group's Specialized Register; MEDLINE (March 2009 to November week 3, 2011); EMBASE (January 2010 to December 2011); MEDLINE In‐Process & Other Non‐Indexed Citations (December 8, 2011); BIOSIS Previews (2009 to December 2011); and CAB Abstracts (2009 to December 2011).

MEDLINE (1950 to April Week 3 2009)

  1. exp Respiratory Tract Infections/

  2. exp Orthomyxoviridae/

  3. Orthomyxoviridae Infections/

  4. Influenza, Human/

  5. exp Picornaviridae/

  6. exp Picornaviridae Infections/

  7. exp Adenoviridae/

  8. Adenovirus Infections, Human/

  9. exp Paramyxoviridae/

  10. exp Paramyxoviridae Infections/

  11. exp Coronaviridae/

  12. exp Coronaviridae Infections/

  13. (influenza adj3 (A or B)).mp.

  14. (human adj2 influenz$).mp.

  15. (metapneumovirus$ or meta‐pneumovirus$ or "meta pneumovirus$").mp.

  16. hMPV$.mp.

  17. pneumovirus$.mp.

  18. (rhinovirus$ or rhino‐virus$ or "rhino virus$").mp.

  19. (orthomyxovirus$ or ortho‐myxovirus$ or "ortho myxovirus$").mp.

  20. (adenovirus$ or adeno‐virus$ or "adeno virus$").mp.

  21. (parainfluenza$ or para‐influenza$ or "para influenza$").mp.

  22. (coronavirus$ or corona‐virus$ or "corona virus$").mp.

  23. (enterovirus$ or entero‐virus$ or "entero virus$").mp.

  24. picornavir$.mp.

  25. respiratory syncytial virus.mp.

  26. RSV.mp.

  27. (acute adj3 respiratory).mp.

  28. (respiratory adj2 virus$).mp.

  29. ARI$.mp.

  30. exp fever/

  31. (febrile adj3 respiratory).mp.

  32. pyrogens/

  33. pyrogen$.mp.

  34. nasal aspirate$.mp.

  35. exp Antigens, Viral/

  36. or/1‐35

  37. exp "sensitivity and specificity"/

  38. (sensitiv$ or specificity).mp.

  39. exp likelihood functions/

  40. (likelihood adj3 ratio$).mp.

  41. (ROC‐curve or ROC curve or receiver operating characteristic curve).sh,mp.

  42. diagnos$.mp.

  43. exp Diagnosis/

  44. (diagnost$ adj (accura$ or sensitiv$ or reliab$ or reliance or value)).af.

  45. di.fs.

  46. (routine adj5 test$).mp.

  47. (false adj (positiv$ or negativ$)).mp.

  48. ((observer adj variation$) or (predictive adj3 value)).mp.

  49. du.fs.

  50. Nasopharynx/

  51. ((virus$ or viral) adj3 (detect$ or antigen?)).mp.

  52. (antigen adj2 (test$ or detection)).mp.

  53. or/37‐52

  54. exp Emergency medicine/

  55. exp Emergencies/

  56. exp Emergency service, hospital/

  57. emergency medical services/

  58. "hospital emergency service?".mp.

  59. ED?.mp.

  60. ER?.mp.

  61. (emergenc$ adj5 (departmen$ or ward$ or service$ or unit$ or room$ or hospital$  or care or patient$ or physician$ or doctor$ or medicine or treatment$ or diagnos$     or resident$)).mp.

  62. (emergency or emergencies).jn.

  63. Point‐of‐Care Systems/

  64. ("point of care" or point‐of‐care or POC).mp.

  65. or/54‐64

  66. exp Infant/

  67. exp Child/

  68. Adolescent/

  69. Minors/

  70. exp Puberty/

  71. exp Pediatrics/

  72. infant$.mp.

  73. infancy.mp.

  74. newborn$.mp.

  75. baby.mp.

  76. babies.mp.

  77. neonat$.mp.

  78. preterm$.mp.

  79. prematur$.mp.

  80. postmatur$.mp.

  81. kid.mp.

  82. kids.mp.

  83. toddler$.mp.

  84. adolescen$.mp.

  85. teen$.mp.

  86. boy$.mp.

  87. girl.mp.

  88. minor$.mp.

  89. pubert$.mp.

  90. pubescen$.mp.

  91. prepubescen$.mp.

  92. pediatric$.mp.

  93. paediatric$.mp.

  94. peadiatric$.mp.

  95. infan$.jw.

  96. child$.jw.

  97. pediatric$.jw.

  98. paediatric$.jw.

  99. adolescen$.jw.

  100. youth$.jw.

  101. school$.jw.

  102. or/66‐101

  103. and/36,53,65,102

  104. clinical trial.pt.

  105. randomi?ed.ti,ab.

  106. placebo.ti,ab.

  107. dt.fs.

  108. randomly.ti,ab.

  109. trial.ti,ab.

  110. groups.ti,ab.

  111. or/104‐110

  112. animals/

  113. humans/

  114. 112 not (112 and 113)

  115. 111 not 114

  116. and/103,115

EBM Reviews ‐ Cochrane Central Register of Controlled Trials (1st quarter 2009)

  1. exp Respiratory Tract Infections/

  2. exp Orthomyxoviridae/

  3. Orthomyxoviridae Infections/

  4. Influenza, Human/

  5. exp Picornaviridae/

  6. exp Picornaviridae Infections/

  7. exp Adenoviridae/

  8. Adenovirus Infections, Human/

  9. exp Paramyxoviridae/

  10. exp Paramyxoviridae Infections/

  11. exp Coronaviridae/

  12. exp Coronaviridae Infections/

  13. (influenza adj3 (A or B)).mp.

  14. (human adj2 influenz$).mp.

  15. (metapneumovirus$ or meta‐pneumovirus$ or "meta pneumovirus$").mp.

  16. hMPV$.mp.

  17. pneumovirus$.mp.

  18. (rhinovirus$ or rhino‐virus$ or "rhino virus$").mp.

  19. (orthomyxovirus$ or ortho‐myxovirus$ or "ortho myxovirus$").mp.

  20. (adenovirus$ or adeno‐virus$ or "adeno virus$").mp.

  21. (parainfluenza$ or para‐influenza$ or "para influenza$").mp.

  22. (coronavirus$ or corona‐virus$ or "corona virus$").mp.

  23. (enterovirus$ or entero‐virus$ or "entero virus$").mp.

  24. picornavir$.mp.

  25. respiratory syncytial virus.mp.

  26. RSV.mp.

  27. (acute adj3 respiratory).mp.

  28. (respiratory adj2 virus$).mp.

  29. ARI$.mp.

  30. exp fever/

  31. (febrile adj3 respiratory).mp.

  32. pyrogens/

  33. pyrogen$.mp.

  34. nasal aspirate$.mp.

  35. exp Antigens, Viral/

  36. or/1‐35

  37. exp "sensitivity and specificity"/

  38. (sensitiv$ or specificity).mp.

  39. exp likelihood functions/

  40. (likelihood adj3 ratio$).mp.

  41. (ROC‐curve or ROC curve or receiver operating characteristic curve).sh,mp.

  42. diagnos$.mp.

  43. exp Diagnosis/

  44. (diagnost$ adj (accura$ or sensitiv$ or reliab$ or reliance or value)).af.

  45. di.fs.

  46. (routine adj5 test$).mp.

  47. (false adj (positiv$ or negativ$)).mp.

  48. ((observer adj variation$) or (predictive adj3 value)).mp.

  49. du.fs.

  50. Nasopharynx/

  51. ((virus$ or viral) adj3 (detect$ or antigen?)).mp.

  52. (antigen adj2 (test$ or detection)).mp.

  53. or/37‐52

  54. exp Emergency medicine/

  55. exp Emergencies/

  56. exp Emergency service, hospital/

  57. emergency medical services/

  58. "hospital emergency service?".mp.

  59. ED?.mp.

  60. ER?.mp.

  61. (emergenc$ adj5 (departmen$ or ward$ or service$ or unit$ or room$ or hospital$ or care or patient$ or physician$ or doctor$ or medicine or treatment$ or diagnos$ or resident$)).mp.

  62. (emergency or emergencies).jn.

  63. Point‐of‐Care Systems/

  64. ("point of care" or point‐of‐care or POC).mp.

  65. or/54‐64

  66. exp Infant/

  67. exp Child/

  68. Adolescent/

  69. Minors/

  70. exp Puberty/

  71. exp Pediatrics/

  72. infant$.mp.

  73. infancy.mp.

  74. newborn$.mp.

  75. baby.mp.

  76. babies.mp.

  77. neonat$.mp.

  78. preterm$.mp.

  79. prematur$.mp.

  80. postmatur$.mp.

  81. kid.mp.

  82. kids.mp.

  83. toddler$.mp.

  84. adolescen$.mp.

  85. teen$.mp.

  86. boy$.mp.

  87. girl.mp.

  88. minor$.mp.

  89. pubert$.mp.

  90. pubescen$.mp.

  91. prepubescen$.mp.

  92. pediatric$.mp.

  93. paediatric$.mp.

  94. peadiatric$.mp.

  95. infan$.jw.

  96. child$.jw.

  97. pediatric$.jw.

  98. paediatric$.jw.

  99. adolescen$.jw.

  100. youth$.jw.

  101. school$.jw.

  102. or/66‐101

  103. and/36,53,65,10

EMBASE search strategy

  1. exp Respiratory Tract Infection/

  2. exp orthomyxovirus/

  3. exp picornavirus/

  4. exp adenovirus/

  5. exp paramyxovirus/

  6. exp coronavirus/

  7. exp Virus Infection/

  8. (influenza adj3 (A or B)).mp.

  9. (human adj2 influenz$).mp.

  10. (metapneumovirus$ or meta‐pneumovirus$ or "meta pneumovirus$").mp.

  11. hMPV$.mp.

  12. pneumovirus$.mp.

  13. (rhinovirus$ or rhino‐virus$ or "rhino virus$").mp.

  14. (orthomyxovirus$ or ortho‐myxovirus$ or "ortho myxovirus$").mp.

  15. (adenovirus$ or adeno‐virus$ or "adeno virus$").mp.

  16. (parainfluenza$ or para‐influenza$ or "para influenza$").mp.

  17. (coronavirus$ or corona‐virus$ or "corona virus$").mp.

  18. (enterovirus$ or entero‐virus$ or "entero virus$").mp.

  19. picornavir$.mp.

  20. respiratory syncytial virus.mp.

  21. RSV.mp.

  22. (acute adj3 respiratory).mp.

  23. (respiratory adj2 virus$).mp.

  24. ARI$.mp.

  25. fever/

  26. pyrexia idiopathica/

  27. (febrile adj3 respiratory).mp.

  28. pyrogen/

  29. pyrogen$.mp.

  30. nasal aspirate$.mp.

  31. exp Virus Antigen/

  32. or/1‐31

  33. exp "sensitivity and specificity"/

  34. (sensitiv$ or specificity).mp.

  35. statistical model/

  36. (likelihood adj3 (function$ or ratio$)).mp.

  37. (ROC‐curve or ROC curve or receiver operating characteristic curve).sh,mp.

  38. diagnos$.mp.

  39. exp Diagnosis/

  40. (diagnost$ adj (accura$ or sensitiv$ or reliab$ or reliance or value)).af.

  41. di.fs.

  42. (routine adj5 test$).mp.

  43. (false adj (positiv$ or negativ$)).mp.

  44. ((observer adj variation$) or (predictive adj3 value)).mp.

  45. du.fs.

  46. exp nasopharynx/

  47. exp oropharynx/

  48. ((virus$ or viral) adj3 (detect$ or antigen?)).mp.

  49. (antigen adj2 (test$ or detection)).mp.

  50. or/33‐49

  51. emergency medicine/

  52. emergency/

  53. emergency health service/

  54. "hospital emergency service?".mp.

  55. ED?.mp.

  56. ER?.mp.

  57. (emergenc$ adj5 (departmen$ or ward$ or service$ or unit$ or room$ or hospital$ or care or patient$ or physician$ or doctor$ or medicine or treatment$ or diagnos$ or resident$)).mp.

  58. (emergency $ or emergencies $).jn.

  59. hospital information system/

  60. medical information system/

  61. ("point of care" or point‐of‐care or POC).mp.

  62. or/51‐61

  63. exp newborn/

  64. exp child/

  65. exp adolescent/

  66. exp adolescence/

  67. exp pediatrics/

  68. infant$.mp.

  69. infancy.mp.

  70. newborn$.mp.

  71. baby.mp.

  72. babies.mp.

  73. neonat$.mp.

  74. preterm$.mp.

  75. prematur$.mp.

  76. postmatur$.mp.

  77. kid.mp.

  78. kids.mp.

  79. child$.mp.

  80. toddler$.mp.

  81. adolescen$.mp.

  82. teen$.mp.

  83. boy$.mp.

  84. girl$.mp.

  85. minor$.mp.

  86. pubert$.mp.

  87. pubescen$.mp.

  88. prepubescen$.mp.

  89. pediatric$.mp.

  90. paediatric$.mp.

  91. peadiatric$.mp.

  92. infan$.jw.

  93. child$.jw.

  94. pediatric$.jw.

  95. paediatric$.jw.

  96. adolescen$.jw.

  97. youth$.jw.

  98. school$.jw.

  99. or/63‐98

  100. and/32,50,62,99

  101. exp clinical trial/

  102. randomi?ed.ti,ab.

  103. placebo.ti,ab.

  104. (ae or dt or to).fs.

  105. randomly.ti,ab.

  106. trial.ti,ab.

  107. groups.ti,ab.

  108. or/101‐107

  109. animal/

  110. human/

  111. 109 not (109 and 110)

  112. 108 not 111

  113. and/100,112

HealthStar (1966 to March 2009)

  1. exp Respiratory Tract Infections/

  2. exp Orthomyxoviridae/

  3. Orthomyxoviridae Infections/

  4. Influenza, Human/

  5. exp Picornaviridae/

  6. exp Picornaviridae Infections/

  7. exp Adenoviridae/

  8. Adenovirus Infections, Human/

  9. exp Paramyxoviridae/

  10. exp Paramyxoviridae Infections/

  11. exp Coronaviridae/

  12. exp Coronaviridae Infections/

  13. (influenza adj3 (A or B)).mp.

  14. (human adj2 influenz$).mp.

  15. (metapneumovirus$ or meta‐pneumovirus$ or "meta pneumovirus$").mp.

  16. hMPV$.mp.

  17. pneumovirus$.mp.

  18. (rhinovirus$ or rhino‐virus$ or "rhino virus$").mp.

  19. (orthomyxovirus$ or ortho‐myxovirus$ or "ortho myxovirus$").mp.

  20. (adenovirus$ or adeno‐virus$ or "adeno virus$").mp.

  21. (parainfluenza$ or para‐influenza$ or "para influenza$").mp.

  22. (coronavirus$ or corona‐virus$ or "corona virus$").mp.

  23. (enterovirus$ or entero‐virus$ or "entero virus$").mp.

  24. picornavir$.mp.

  25. respiratory syncytial virus.mp.

  26. RSV.mp.

  27. (acute adj3 respiratory).mp.

  28. (respiratory adj2 virus$).mp.

  29. ARI$.mp.

  30. exp fever/

  31. (febrile adj3 respiratory).mp.

  32. pyrogens/

  33. pyrogen$.mp.

  34. nasal aspirate$.mp.

  35. exp Antigens, Viral/

  36. or/1‐35

  37. exp "sensitivity and specificity"/

  38. (sensitiv$ or specificity).mp.

  39. exp likelihood functions/

  40. (likelihood adj3 ratio$).mp.

  41. (ROC‐curve or ROC curve or receiver operating characteristic curve).sh,mp.

  42. diagnos$.mp.

  43. exp Diagnosis/

  44. (diagnost$ adj (accura$ or sensitiv$ or reliab$ or reliance or value)).af.

  45. di.fs.

  46. (routine adj5 test$).mp.

  47. (false adj (positiv$ or negativ$)).mp.

  48. ((observer adj variation$) or (predictive adj3 value)).mp.

  49. du.fs.

  50. Nasopharynx/

  51. ((virus$ or viral) adj3 (detect$ or antigen?)).mp.

  52. (antigen adj2 (test$ or detection)).mp.

  53. or/37‐52

  54. exp Emergency medicine/

  55. exp Emergencies/

  56. exp Emergency service, hospital/

  57. emergency medical services/

  58. "hospital emergency service?".mp.

  59. ED?.mp.

  60. ER?.mp.

  61. (emergenc$ adj5 (departmen$ or ward$ or service$ or unit$ or room$ or hospital$ or care or patient$ or physician$ or doctor$ or medicine or treatment$ or diagnos$ or resident$)).mp.

  62. (emergency $ or emergencies $).jn.

  63. Point‐of‐Care Systems/

  64. ("point of care" or point‐of‐care or POC).mp.

  65. or/54‐64

  66. exp Infant/

  67. exp Child/

  68. Adolescent/

  69. Minors/

  70. exp Puberty/

  71. exp Pediatrics/

  72. infant$.mp.

  73. infancy.mp.

  74. newborn$.mp.

  75. baby.mp.

  76. babies.mp.

  77. neonat$.mp.

  78. preterm$.mp.

  79. prematur$.mp.

  80. postmatur$.mp.

  81. kid.mp.

  82. kids.mp.

  83. toddler$.mp.

  84. adolescen$.mp.

  85. teen$.mp.

  86. boy$.mp.

  87. girl.mp.

  88. minor$.mp.

  89. pubert$.mp.

  90. pubescen$.mp.

  91. prepubescen$.mp.

  92. pediatric$.mp.

  93. paediatric$.mp.

  94. peadiatric$.mp.

  95. infan$.jw.

  96. child$.jw.

  97. pediatric$.jw.

  98. paediatric$.jw.

  99. adolescen$.jw.

  100. youth$.jw.

  101. school$.jw.

  102. or/66‐101

  103. and/36,53,65,102

  104. clinical trial.pt.

  105. randomi?ed.ti,ab.

  106. placebo.ti,ab.

  107. dt.fs.

  108. randomly.ti,ab.

  109. trial.ti,ab.

  110. groups.ti,ab.

  111. or/104‐110

  112. limit 111 to humans

  113. and/103,112

Ovid MEDLINE In‐Process & Other
Non‐Indexed Citations (27 April 2009)

  1. (influenza adj3 (A or B)).mp.

  2. (human adj2 influenz$).mp.

  3. (metapneumovirus$ or meta‐pneumovirus$ or "meta pneumovirus$").mp.

  4. hMPV$.mp.

  5. pneumovirus$.mp.

  6. (rhinovirus$ or rhino‐virus$ or "rhino virus$").mp.

  7. (orthomyxovir$ or ortho‐myxovir$ or "ortho myxovir$").mp.

  8. (adenovir$ or adeno‐vir$ or "adeno vir$").mp.

  9. (parainfluenza$ or para‐influenza$ or "para influenza$").mp.

  10. (paramyxovir$ or para‐myxovir$ or "para myxovir$").mp.

  11. (coronavirus$ or corona‐virus$ or "corona virus$").mp.

  12. (enterovirus$ or entero‐virus$ or "entero virus$").mp.

  13. picornavir$.mp.

  14. respiratory syncytial virus.mp.

  15. RSV.mp.

  16. (acute adj3 respiratory).mp.

  17. (respiratory adj2 (virus$ or infection?)).mp.

  18. ARI$.mp.

  19. fever.mp.

  20. (febrile adj3 respiratory).mp.

  21. pyrogen$.mp.

  22. nasal aspirate$.mp.

  23. (viral adj3 antigen$).mp.

  24. or/1‐23

  25. (sensitiv$ or specificity).mp.

  26. (likelihood adj3 (function$ or ratio$)).mp.

  27. (ROC‐curve or ROC curve or receiver operating characteristic curve).mp.

  28. diagnos$.mp.

  29. (diagnost$ adj (accura$ or sensitiv$ or reliab$ or reliance or value)).af.

  30. (routine adj5 test$).mp.

  31. (false adj (positiv$ or negativ$)).mp.

  32. ((observer adj variation$) or (predictive adj3 value)).mp.

  33. nasopharynx.mp.

  34. ((virus$ or viral) adj3 (detect$ or antigen?)).mp.

  35. (antigen adj2 (test$ or detection)).mp.

  36. or/25‐35

  37. "hospital emergency service?".mp.

  38. ED?.mp.

  39. ER?.mp.

  40. (emergenc$ adj5 (departmen$ or ward$ or service$ or unit$ or room$ or hospital$ or care or patient$ or physician$ or doctor$ or medicine or treatment$ or diagnos$ or resident$)).mp.

  41. (emergency or emergencies).jn,mp.

  42. ("point of care" or point‐of‐care or POC).mp.

  43. or/37‐42

  44. infant$.mp.

  45. infancy.mp.

  46. newborn$.mp.

  47. baby.mp.

  48. babies.mp.

  49. neonat$.mp.

  50. preterm$.mp.

  51. prematur$.mp.

  52. postmatur$.mp.

  53. kid.mp.

  54. kids.mp.

  55. toddler$.mp.

  56. adolescen$.mp.

  57. teen$.mp.

  58. boy$.mp.

  59. girl.mp.

  60. minor$.mp.

  61. pubert$.mp.

  62. pubescen$.mp.

  63. prepubescen$.mp.

  64. pediatric$.mp.

  65. paediatric$.mp.

  66. peadiatric$.mp.

  67. infan$.jw.

  68. child$.jw.

  69. pediatric$.jw.

  70. paediatric$.jw.

  71. adolescen$.jw.

  72. youth$.jw.

  73. school$.jw.

  74. or/44‐73

  75. and/24,36,43,74

  76. clinical trial.pt.

  77. randomi?ed.ti,ab.

  78. placebo.ti,ab.

  79. dt.fs.

  80. randomly.ti,ab.

  81. trial.ti,ab.

  82. groups.ti,ab.

  83. or/76‐82

  84. and/76,83

BIOSIS Previews ISI Web of KnowledgeSM v3.0 (1969 to April 2009)

Set

Search

#9

#8 AND #7

#8

TS=clinical trial* OR TS=research design OR TS=comparative stud* OR TS=evaluation stud* OR TS=controlled trial* OR TS=follow‐up stud* OR TS=prospective stud* OR TS=random* OR TS=placebo* OR TS=(single blind*) OR TS=(double blind*)

#7

#6 AND #5

#6

TS=(hospital SAME emergency SAME service*) OR TS=(ED or EDS) OR TS=(ER or ERs) OR TS=(emergenc* SAME departmen*) OR TS=(emergenc* SAME ward*) OR TS=(emergenc* SAME service*) OR TS=(emergenc* SAME unit*) OR TS=(emergenc* SAME room*) OR TS=(emergenc* SAME hospital*) OR TS=(emergenc* SAME care) OR TS=(emergenc* SAME patient*) OR TS=(emergenc* SAME physician*) OR TS=(emergenc* SAME doctor*) OR TS=(emergenc* SAME medicine) OR TS=(emergenc* SAME treatment*) OR TS=(emergenc* SAME diagnos*) OR TS=(emergenc* SAME resident*) OR TS=(emergency OR emergencies) OR TS=("point of care" OR point‐of‐care OR POC)

#5

#4 AND #3

#4

TS=(sensitiv* OR specificity) OR TS=(likelihood SAME function*) OR TS=(likelihood SAME ratio*) OR TS=(ROC‐curve OR "ROC curve") OR TS=(receiver SAME operating SAME characteristic SAME curve) OR TS=diagnos* OR TS=(diagnost* SAME accura*) OR TS=(diagnost* SAME sensitiv*) OR TS=(diagnost* SAME reliab*) OR TS=(diagnost* SAME reliance) OR TS=(diagnost* SAME value) OR TS=(routine SAME test*) OR TS=(false SAME positiv*) OR TS=(false SAME negativ*) OR TS=(observer SAME variation*) OR TS=(predictive SAME value) OR TS=nasopharynx OR TS=(vir* SAME detect*) OR TS=(vir* SAME antigen*) OR TS=(antigen SAME test*) OR TS=(antigen SAME detection)

#3

#2 AND #1

#2

TS=(influenza SAME A) OR TS=(influenza SAME B) OR TS=(human SAME influenz*) OR TS=(metapneumovirus* OR meta‐pneumovirus* OR "meta pneumovirus*" OR hMPV* OR pneumovirus* OR rhinovirus* OR rhino‐virus* OR "rhino virus*" OR orthomyxovir* OR ortho‐myxovir* OR "ortho myxovir*" OR adenovir* or adeno‐vir* or "adeno vir*" OR parainfluenza* OR para‐influenza* OR "para influenza*" OR paramyxovir* OR para‐myxovir* OR "para myxovir*" OR coronavirus* OR corona‐virus* OR "corona virus*" OR enterovirus* OR entero‐virus* OR "entero virus*" OR picornavir*) OR TS=(respiratory SAME syncytial SAME virus) OR TS=RSV OR TS=(acute SAME respiratory) OR TS=(respiratory SAME infection*) OR TS=ARI* OR TS=fever OR TS=(febrile SAME respiratory) OR TS=pyrogen* OR TS=(nasal SAME aspirate*) OR TS=(viral SAME antigen*)

#1

TS=(infant* OR infancy OR newborn* OR baby OR babies OR neonat* OR preterm* OR prematur* OR postmatur* OR kid OR kids OR toddler* OR adolescen* OR teen* OR boy* OR girl OR minor* OR pubert* OR pubescen* OR prepubescen* OR pediatric* OR paediatric* OR peadiatric*)

DocType=All document types; LitType=All literature types; Language=All languages; Taxa Notes=All Taxa Notes; Database=BIOSIS Previews; Timespan=1969‐2009

CAB Abstracts via ERL WebSPIRS 5.12 (1973 to 2007)

 Search

Results

#54

#53 and #52

1

#53

#6 and #23 and #34 and #42

26

#52

( #50 )not( #51 )

92642

#51

( (human) in DE )not( (nonhuman) in DE )

202376

#50

(explode "randomized‐controlled‐trials" in BT,DE,GE,OD) or (( (controlled clinical trial*) in TI )or( (controlled clinical trial*) in AB )) or (( (random* or placebo* or double‐blind) in TI )or( (random* or placebo* or double‐blind) in AB )) or (( (randomi?ed controlled trial) in TI )or( (randomi?ed controlled trial) in AB )) or (( (single‐blind‐procedure) in SU )or( (double‐blind‐procedure) in SU )or( (crossover‐procedure) in SU )) or (explode "clinical‐trials" in BT,DE,GE,OD) or (explode "randomized‐controlled‐trials" in BT,DE,GE,OD)

105526

#49

( (controlled clinical trial*) in TI )or( (controlled clinical trial*) in AB )

771

#48

( (random* or placebo* or double‐blind) in TI )or( (random* or placebo* or double‐blind) in AB )

103451

#47

( (randomi?ed controlled trial) in TI )or( (randomi?ed controlled trial) in AB )

2608

#46

( (single‐blind‐procedure) in SU )or( (double‐blind‐procedure) in SU )or( (crossover‐procedure) in SU )

0

#45

explode "clinical‐trials" in BT,DE,GE,OD

6239

#44

explode "randomized‐controlled‐trials" in BT,DE,GE,OD

3452

#43

explode "randomized‐controlled‐trials" in BT,DE,GE,OD

3452

#42

(( emergenc* medicine )or( emergenc* treatment* )or( emergenc* diagnos* )) or (( emergenc* patient* )or( emergenc* physician* )or( emergenc* doctor* )) or (( emergenc* room* )or( emergenc* hospital* )or( emergenc*care )) or (( emergenc* departmen* )or( emergenc* ward* )or( emergenc* unit* )) or (( (hospital emergency service*) in AB )or( (ER*) in AB )or( (ED*) in AB )) or (( (hospital emergency service*) in TI )or( (ER*) in TI )or( (ED*) in TI )) or (( emergenc* resident )or( point of care )or( POC ))

335359

#41

( emergenc* resident )or( point of care )or( POC )

312

#40

( emergenc* medicine )or( emergenc* treatment* )or( emergenc* diagnos* )

1251

#39

( emergenc* patient* )or( emergenc* physician* )or( emergenc* doctor* )

62

#38

( emergenc* room* )or( emergenc* hospital* )or( emergenc*care )

315

#37

( emergenc* departmen* )or( emergenc* ward* )or( emergenc* unit* )

582

#36

( (hospital emergency service*) in AB )or( (ER*) in AB )or( (ED*) in AB )

305566

#35

( (hospital emergency service*) in TI )or( (ER*) in TI )or( (ED*) in TI )

79346

#34

(explode "statistical‐analysis" in BT,DE,GE,OD) or (explode "nasopharynx‐" in BT,DE,GE,OD) or (( antigen test* )or( antigen detection )) or (( vir* detection )or( vir* antigen )) or (( observer variation )or( predictive value )) or (( ROC‐curve )or( receiver operating characteristic curve )) or (("false‐negative‐results" in BT,DE,GE,OD) or ("false‐positive‐results" in BT,DE,GE,OD)) or (explode "diagnosis‐" in BT,DE,GE,OD) or (( (likelihood ratio) in AB )or( (likelihood function) in AB )) or (( (sensitiv*) in AB )or( (specificity) in AB ))

297894

#33

explode "nasopharynx‐" in BT,DE,GE,OD

246

#32

( antigen test* )or( antigen detection )

1839

#31

( vir* detection )or( vir* antigen )

3248

#30

( observer variation )or( predictive value )

2341

#29

( ROC‐curve )or( receiver operating characteristic curve )

138

#28

("false‐negative‐results" in BT,DE,GE,OD) or ("false‐positive‐results" in BT,DE,GE,OD)

338

#27

explode "diagnosis‐" in BT,DE,GE,OD

108639

#26

( (likelihood ratio) in AB )or( (likelihood function) in AB )

653

#25

( (sensitiv*) in AB )or( (specificity) in AB )

166410

#24

explode "statistical‐analysis" in BT,DE,GE,OD

34711

#23

(nasal aspirate*) or (("fever‐" in BT,DE,GE,OD) or ("pyrogens‐" in BT,DE,GE,OD)) or (explode "Paramyxoviridae‐" in BT,DE,GE,OD) or (( (influenza ) in TI )or( (influenza ) in AB )) or (explode "influenza‐" in BT,DE,GE,OD) or ((explode "human‐respiratory‐syncytial‐virus" in BT,DE,GE,OD) or (explode "lower‐respiratory‐tract‐infections" in BT,DE,GE,OD)) or (( (ARI*) in TI )or( (ARI*) in AB )) or (( (respiratory infection*) in TI )or( (respiratory infection*) in AB )) or (( (respiratory virus*) in TI )or( (respiratory virus*) in AB )) or (( (acute respiratory) in TI )or( (acute respiratory) in AB )) or (explode "Enterovirus‐" in BT,DE,GE,OD) or (explode "Coronavirus‐" in BT,DE,GE,OD) or (explode "parainfluenza‐virus" in BT,DE,GE,OD) or (explode "human‐adenovirus" in BT,DE,GE,OD) or (explode "Orthomyxoviridae‐" in BT,DE,GE,OD) or (explode "Rhinovirus‐" in BT,DE,GE,OD)

100764

#22

nasal aspirate*

12

#21

("fever‐" in BT,DE,GE,OD) or ("pyrogens‐" in BT,DE,GE,OD)

2017

#20

( (ARI*) in TI )or( (ARI*) in AB )

71333

#19

( (respiratory infection*) in TI )or( (respiratory infection*) in AB )

1585

#18

( (respiratory virus*) in TI )or( (respiratory virus*) in AB )

315

#17

( (acute respiratory) in TI )or( (acute respiratory) in AB )

1515

#16

explode "Enterovirus‐" in BT,DE,GE,OD

2861

#15

explode "Coronavirus‐" in BT,DE,GE,OD

5393

#14

explode "parainfluenza‐virus" in BT,DE,GE,OD

463

#13

explode "human‐adenovirus" in BT,DE,GE,OD

137

#12

explode "Orthomyxoviridae‐" in BT,DE,GE,OD

5908

#11

explode "Rhinovirus‐" in BT,DE,GE,OD

270

#10

explode "Paramyxoviridae‐" in BT,DE,GE,OD

10783

#9

( (influenza ) in TI )or( (influenza ) in AB )

6414

#8

explode "influenza‐" in BT,DE,GE,OD

1953

#7

(explode "human‐respiratory‐syncytial‐virus" in BT,DE,GE,OD) or (explode "lower‐respiratory‐tract‐infections" in BT,DE,GE,OD)

364

#6

(( (paediatric*) in AB )or( (pediatric*) in AB )or( (pediatric*) in AB )) or (( (paediatric* ) in TI )or( (pediatric*) in TI )or( (peadtric*) in TI )) or (explode "adolescents‐" in BT,DE,GE,OD) or (explode "children‐" in BT,DE,GE,OD) or (explode "infants‐" in BT,DE,GE,OD)

70047

#5

( (paediatric*) in AB )or( (pediatric*) in AB )or( (pediatric*) in AB )

4679

#4

( (paediatric* ) in TI )or( (pediatric*) in TI )or( (peadtric*) in TI )

1898

#3

explode "adolescents‐" in BT,DE,GE,OD

7452

#2

explode "children‐" in BT,DE,GE,OD

48050

#1

explode "infants‐" in BT,DE,GE,OD

23356

CBCA ProQuest (1970 to 2007)

("acute respiratory" OR ARI OR influenza) AND ( diagnos*) AND (emergenc* or ED* or ER* OR "point of care" OR POC) AND (infant* or child* or adolescen* OR pediatric* ) Limit: Scholarly documents  

ProQuest Dissertations and Theses ‐ full text (1861 to 2009)

("acute respiratory" OR ARI OR influenza) AND ( diagnos*) AND (emergenc* or ED* or ER* OR "point of care" OR POC) AND (infant* or child* or adolescen* OR pediatric* ) Limit: Scholarly documents.

Appendix 2. MEDLINE and CENTRAL search strategy

MEDLINE (Ovid)

1 exp Respiratory Tract Infections/ (290367)
2 (acute adj3 respiratory).tw. (26567)
3 (respiratory adj3 virus*).tw. (13969)
4 ari*.tw. (183543)
5 exp Orthomyxoviridae/ (43377)
6 Orthomyxoviridae Infections/ (7451)
7 (orthomyxovir* or ortho myxovirus* or ortho‐myxovirus*).tw. (370)
8 Influenza, Human/ (35678)
9 (influenza* or flu).tw. (85736)
10 exp Picornaviridae/ (32222)
11 exp Picornaviridae Infections/ (50584)
12 picornavir*.tw. (2623)
13 (rhinovir* or rhino virus* or rhino‐virus*).tw. (3542)
14 exp Adenoviridae/ (31925)
15 Adenovirus Infections, Human/ (1948)
16 (adenovir* or adeno virus* or adeno‐virus*).tw. (42465)
17 exp Paramyxoviridae/ (28456)
18 exp Paramyxoviridae Infections/ (29849)
19 exp Coronaviridae/ (9326)
20 (coronavir* or corona‐virus* or corona virus*).tw. (7191)
21 exp Coronaviridae Infections/ (7725)
22 (metapneumovir* or meta‐pneumovir* or meta pneumovir*).tw. (1197)
23 hmpv*.tw. (691)
24 pneumovir*.tw. (316)
25 (parainfluenza* or para influenza* or para‐influenza*).tw. (5142)
26 (enterovirus* or entero‐virus* or entero virus*).tw. (6601)
27 (respiratory syncytial virus* or rsv).tw. (11646)
28 fever/ or "fever of unknown origin"/ (34398)
29 (febrile adj3 respiratory).tw. (390)
30 Pyrogens/ (2711)
31 pyrogen*.tw. (4947)
32 exp Antigens, Viral/ (93160)
33 ((viral or virus) adj2 antigen*).tw. (17026)
34 nasal aspirat*.tw. (126)
35 or/1‐34 (803679)
36 exp "Sensitivity and Specificity"/ (419518)
37 (sensitiv* or specific*).tw. (2663003)
38 likelihood functions/ (17250)
39 (likelihood* adj3 ratio*).tw. (8429)
40 ((roc* or receiver operating characteristic) adj2 curve*).tw. (25089)
41 exp Diagnosis/ (6526369)
42 diagnos*.tw. (1553648)
43 di.fs. (2002607)
44 (routine adj5 test*).tw. (13308)
45 (false adj2 (positiv* or negativ*)).tw. (53674)
46 (observer adj2 variation*).tw. (958)
47 (predictive adj3 value).tw. (54963)
48 du.fs. (331591)
49 Nasopharynx/ (7064)
50 ((viral* or virus* or virol* or antigen* or antibod*) adj3 (test* or detect* or diagnos*)).tw. (120218)
51 ((viral or virus*) adj3 antigen?).tw. (20386)
52 or/36‐51 (9445888)
53 Emergency Medicine/ (9841)
54 Emergencies/ (34355)
55 exp Emergency Service, Hospital/ (49741)
56 Emergency Medical Services/ (32117)
57 (ed? or er?).tw. (197478)
58 (emergenc* adj5 (department* or ward* or service* or unit* or room* or hospital* or care* or patient* or physician* or doctor* or medicine or treatment* or diagnos* or resident*)).tw. (103070)
59 (emergency or emergencies).jn. (128)
60 Point‐of‐Care Systems/ (7215)
61 ("point of care" or point‐of‐care or poc).tw. (7100)
62 or/53‐61 (358623)
63 exp Infant/ (937498)
64 (infant* or infancy or newborn* or baby* or babies or neonat* or preterm* or prematur*).tw. (613296)
65 exp Child/ (1549368)
66 (child* or schoolchild* or school age* or preschool* or kid or kids or toddler*).tw. (953267)
67 Adolescent/ (1618145)
68 (adoles* or teen* or boy* or girl*).tw. (313883)
69 Minors/ (2320)
70 Puberty/ (11193)
71 (minor* or pubert* or pubescen*).tw. (227288)
72 exp Pediatrics/ (43680)
73 (pediatric* or paediatric*).tw. (206748)
74 exp Schools/ (81470)
75 (nursery school* or kindergar* or primary school* or secondary school* or elementary school* or high school* or highschool*).tw. (39946)
76 or/63‐75 (3504613)
77 randomized controlled trial.pt. (378135)
78 controlled clinical trial.pt. (88788)
79 randomized.ab. (276180)
80 placebo.ab. (147508)
81 clinical trials as topic.sh. (170979)
82 randomly.ab. (195598)
83 trial.ti. (119243)
84 77 or 78 or 79 or 80 or 81 or 82 or 83 (866547)
85 exp animals/ not humans.sh. (3966430)
86 84 not 85 (795983)
87 35 and 52 and 62 and 76 and 86 (204)

Appendix 3. EMBASE.com search strategy

#64. #60 AND #63
#63. #61 OR #62
#62. random*:ab,ti OR placebo*:ab,ti OR factorial*:ab,ti OR crossover*:ab,ti OR 'cross over':ab,ti OR 'cross‐over':ab,ti OR volunteer*:ab,ti OR assign*:ab,ti OR allocat*:ab,ti OR ((singl* OR doubl*) NEAR/1 blind*):ab,ti AND [embase]/lim
#61. 'randomized controlled trial'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover procedure'/exp AND [embase]/lim 241,796 12 May 2011
#60. #56 AND #59
#59. #57 OR #58
#58. infant*:ab,ti OR infancy:ab,ti OR newborn*:ab,ti OR baby*:ab,ti OR babies:ab,ti OR neonat*:ab,ti OR preterm*:ab,ti OR prematur*:ab,ti OR child*:ab,ti OR schoolchild*:ab,ti OR 'school age':ab,ti OR 'school aged':ab,ti OR 'school ages':ab,ti OR preschool*:ab,ti OR kid:ab,ti OR kids:ab,ti OR toddler*:ab,ti OR adoles*:ab,ti OR teen*:ab,ti OR boy*:ab,ti OR girl*:ab,ti OR minor*:ab,ti OR juvenile*:ab,ti OR pubert*:ab,ti OR pubescen*:ab,ti OR pediatric*:ab,ti OR paediatric*:ab,ti OR kindergar*:ab,ti OR (school* NEAR/1 (primary OR nursery OR secondary OR elementary OR high)):ab,ti OR highschool*:ab,ti AND [embase]/lim
#57. 'infant'/exp OR 'child'/exp OR 'adolescent'/exp OR 'pediatrics'/exp AND [embase]/lim
#56. #35 AND #48 AND #55
#55. #49 OR #50 OR #51 OR #52 OR #53 OR #54
#54. 'point of care':ab,ti OR 'point‐of‐care':ab,ti OR poc:ab,ti AND [embase]/lim
#53. 'hospital information system'/de AND [embase]/lim
#52. emergency:jt OR emergencies:jt AND [embase]/lim
#51. ed?:ab,ti OR er?:ab,ti AND [embase]/lim
#50. (emergenc* NEAR/5 (department* OR ward* OR service* OR unit* OR room* OR hospital* OR care* OR patient* OR physician* OR doctor* OR medicine OR treatment* OR diagnos* OR resident*)):ab,ti AND [embase]/lim
#49. 'emergency medicine'/de OR 'emergency'/de OR 'emergency health service'/de AND [embase]/lim
#48. #36 OR #37 OR #38 OR #39 OR #40 OR #41 OR #42 OR #43 OR #44 OR #45 OR #46 OR #47
#47. ((viral* OR virus*) NEAR/3 antigen*):ab,ti AND [embase]/lim
#46. ((viral* OR virus* OR virol* OR antigen* OR antibod*) NEAR/3 (test* OR detect* OR diagnos*)):ab,ti AND [embase]/lim
#45. 'nasopharynx'/de AND [embase]/lim
#44. (routine NEAR/5 test*):ab,ti OR (false NEAR/2 positiv*):ab,ti OR (false NEAR/2 negative*):ab,ti OR (observer NEAR/2 variation*):ab,ti OR (predictive NEAR/2 value*):ab,ti AND [embase]/lim
#43. diagnos*:ab,ti AND [embase]/lim
#42. 'diagnosis'/exp AND [embase]/lim
#41. ('receiver operating characteristic' NEAR/2 curve*):ab,ti OR (roc NEAR/2 curve*):ab,ti AND [embase]/lim
#40. 'receiver operating characteristic'/de AND [embase]/lim
#39. (likelihood NEAR/3 ratio*):ab,ti AND [embase]/lim
#38. 'statistical model'/de AND [embase]/lim 25,607
#37. sensitivit*:ab,ti OR specific*:ab,ti AND [embase]/lim
#36. 'sensitivity and specificity'/de AND [embase]/lim
#35. #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34
#34. (nasal NEAR/1 aspirat*):ab,ti AND [embase]/lim
#33. ((viral OR virus) NEAR/2 antigen*):ab,ti AND [embase]/lim
#32. 'virus antigen'/exp AND [embase]/lim
#31. pyrogen*:ab,ti AND [embase]/lim
#30. 'pyrogen'/de AND [embase]/lim
#29. (febrile NEAR/3 respiratory):ab,ti AND [embase]/lim
#28. 'fever'/de OR 'pyrexia idiopathica'/de AND [embase]/lim
#27. 'respiratory syncytial virus':ab,ti OR 'respiratory syncytial viruses':ab,ti OR rsv:ab,ti AND [embase]/lim
#26. enterovir*:ab,ti OR 'entero virus':ab,ti OR 'entero viruses':ab,ti OR 'entero‐virus':ab,ti OR 'entero‐viruses':ab,ti AND [embase]/lim
#25. parainfluenza*:ab,ti OR 'para influenza':ab,ti OR 'para‐influenza':ab,ti AND [embase]/lim
#24. pneumovir*:ab,ti AND [embase]/lim
#23. hmpv:ab,ti AND [embase]/lim
#22. metapneumovir*:ab,ti OR 'meta pneumovirus':ab,ti OR 'meta pneumoviruses':ab,ti OR 'meta‐pneumovirus':ab,ti OR 'meta‐pneumoviruses':ab,ti AND [embase]/lim 882 12 May 2011
#21. coronavir*:ab,ti OR 'corona virus':ab,ti OR 'corona‐virus':ab,ti OR 'corona viruses':ab,ti AND [embase]/lim
#20. 'coronavirus infection'/de AND [embase]/lim
#19. 'coronavirus'/exp AND [embase]/lim
#18. 'paramyxovirus infection'/exp AND [embase]/lim
#17. 'paramyxovirus'/exp AND [embase]/lim
#16. adenovir*:ab,ti OR 'adeno‐virus':ab,ti OR 'adeno‐viruses':ab,ti OR 'adeno virus':ab,ti OR 'adeno viruses':ab,ti AND [embase]/lim
#15. 'human adenovirus infection'/de AND [embase]/lim
#14. 'adenovirus'/exp AND [embase]/lim
#13. rhinovir*:ab,ti OR 'rhino virus':ab,ti OR 'rhino viruses':ab,ti OR 'rhino‐virus':ab,ti OR 'rhino‐viruses':ab,ti AND [embase]/lim
#12. picornavir*:ab,ti AND [embase]/lim
#11. 'picornavirus infection'/exp AND [embase]/lim
#10. 'picornavirus'/exp AND [embase]/lim
#9. influenza*:ab,ti AND [embase]/lim
#8. 'influenza'/exp AND [embase]/lim
#7. orthomyxovirus*:ab,ti OR 'ortho myxovirus':ab,ti OR 'ortho myxoviruses':ab,ti OR 'ortho‐myxovirus':ab,ti OR 'ortho‐myxoviruses':ab,ti AND [embase]/lim
#6. 'orthomyxovirus infection'/de AND [embase]/lim
#5. 'orthomyxovirus'/exp AND [embase]/lim
#4. ari:ab,ti AND [embase]/lim
#3. (respiratory NEAR/3 virus*):ab,ti AND [embase]/lim
#2. (acute NEAR/3 respiratory):ab,ti AND [embase]/lim
#1. 'respiratory tract infection'/exp AND [embase]/lim

Appendix 4. MEDLINE (Ovid) In‐Process and Other Non‐Indexed Citations

1 (respiratory adj3 (infection* or acute or virus*)).tw.
2 (ari* or orthomyxovir* or influenz* or picornavir* or rhinovir* or coronavir* or metapneumovir* or hmpv or pneumovir* or parainfluenz* or enterovir* or respiratory syncytial vir* or rsv or fever* or pyrogen*).tw.
3 (febrile adj3 respiratory).tw.
4 ((viral or virus*) adj2 antigen*).tw.
5 nasal aspirat*.tw.
6 or/1‐5
7 (sensitive* or specific* or likelihood* or roc or receiver operating characteristic* or diagnos*).tw.
8 (routine adj5 test*).tw.
9 (false adj2 (positive* or negative*)).tw.
10 (observer adj2 variation*).tw.
11 (predictiv* adj3 value*).tw.
12 nasopharynx.tw.
13 ((viral* or virus* or virol* or antigen* or antibod*) adj3 (test* or detect* or diagnos*)).tw.
14 ((viral* or virus*) adj3 antigen*).tw.
15 or/7‐14
16 6 and 15
17 emergenc*.tw.
18 (point‐of‐care or point of care or poc).tw.
19 (ed? or er?).tw.
20 or/17‐19
21 16 and 20
22 (infant* or infancy or newborn* or baby* or babies or neonat* or preterm* or prematur*).tw.
23 (child* or schoolchild* or school age* or preschool* or kid or kids or toddler*).tw.
24 (adoles* or teen* or boy* or girl*).tw.
25 (minor* or juvenile* or pubert* or pubescen*).tw.
26 (pediatric* or paediatric*).tw.
27 (nursery school* or kindergar* or primary school* or secondary school* or elementary school* or high school* or highschool*).tw.
28 or/22‐27
29 21 and 28
30 (random* or placebo* or trial* or doubl* blind* or singl* blind*).tw.
31 29 and 30

Appendix 5. Biosis Previews (Thomson Reuters)

# 9

158

#8 AND #7

Indexes=BIOSIS Previews Timespan=All years

 

# 8

2,200,348

TOPIC: ("clinical trial*" or "research design*" or "comparative stud*" or "evaluation stud*" or "controlled trial*" or "follow‐up stud*" or "prospectiv* stud*" or random* or placebo* or ((singl* or doubl*) NEAR/1 blind*))

Indexes=BIOSIS Previews Timespan=All years

 

# 7

1,353

#6 AND #5

Indexes=BIOSIS Previews Timespan=All years

 

# 6

2,018,594

TOPIC: (infant* or infancy or newborn* or baby* or babies* or neonat* or preterm* or prematur* or child* or schoolchild* or preschool* or kid or kids or toddler* or adoles* or teen* or boy* or girl* or puberty or pubescen* or minor* or juvenile* or pediatric* or paediatric* or school* or kindergar* or highschool*)

Indexes=BIOSIS Previews Timespan=All years

 

# 5

4,514

#4 AND #3

Indexes=BIOSIS Previews Timespan=All years

 

# 4

629,384

TOPIC: (emergenc* or ed or er or point‐of‐care or "point of care" or poc)

Indexes=BIOSIS Previews Timespan=All years

 

# 3

139,662

#2 AND #1

Indexes=BIOSIS Previews Timespan=All years

 

# 2

5,503,526

TOPIC: (sensitiv* or specific* or likelihood* or "roc* curve*" or "receiver operating characteristic*" or diagnos* or "routine test*" or "false positiv*" or "false negativ*" or "observer variation*" or "predictive value*" or nasopharynx* or ((viral or virus* or antigen* or antibod*) NEAR/1 (test* or detect*)))

Indexes=BIOSIS Previews Timespan=All years

 

# 1

374,180

TOPIC: ("respiratory tract infection*" or "respiratory infection*" or ari or orthomyxovir* or influenz* or picornavir* or rhinovir* or adenovir* or paramyxovir* or coronavir* or metapneumovir* or hmpv or pneumovir* or parainfluenz* or enterovir* or "respiratory syncytial virus*" or rsv or fever* or pyrogen* or ((viral or virus) NEAR/1 antigen*) or "nasal aspirat*")

Indexes=BIOSIS Previews Timespan=All years

Appendix 6. CAB Abstracts (Thomson Reuters)

# 7

14

#6 AND #5

Indexes=CAB Abstracts Timespan=All years

 

# 6

308,391

TOPIC: ("clinical trial*" or "research design*" or "comparative stud*" or "evaluation stud*" or "controlled trial*" or "follow‐up stud*" or "prospectiv* stud*" or random* or placebo* or ((singl* or doubl*) NEAR/1 blind*))

Indexes=CAB Abstracts Timespan=All years

 

# 5

235

#4 AND #3 AND #2 AND #1

Indexes=CAB Abstracts Timespan=All years

 

# 4

506,114

TOPIC: (infant* or infancy or newborn* or baby* or babies* or neonat* or preterm* or prematur* or child* or schoolchild* or preschool* or kid or kids or toddler* or adoles* or teen* or boy* or girl* or puberty or pubescen* or minor* or juvenile* or pediatric* or paediatric* or school* or kindergar* or highschool*)

Indexes=CAB Abstracts Timespan=All years

 

# 3

142,175

TOPIC: (emergenc* or ed or er or point‐of‐care or "point of care" or poc)

Indexes=CAB Abstracts Timespan=All years

 

# 2

1,227,918

TOPIC: (sensitiv* or specific* or likelihood* or "roc* curve*" or "receiver operating characteristic*" or diagnos* or "routine test*" or "false positiv*" or "false negativ*" or "observer variation*" or "predictive value*" or nasopharynx* or ((viral or virus* or antigen* or antibod*) NEAR/1 (test* or detect*)))

Indexes=CAB Abstracts Timespan=All years

 

# 1

155,699

TOPIC: ("respiratory tract infection*" or "respiratory infection*" or ari or orthomyxovir* or influenz* or picornavir* or rhinovir* or adenovir* or paramyxovir* or coronavir* or metapneumovir* or hmpv or pneumovir* or parainfluenz* or enterovir* or "respiratory syncytial virus*" or rsv or fever* or pyrogen* or ((viral or virus) NEAR/1 antigen*) or "nasal aspirat*")

Indexes=CAB Abstracts Timespan=All years

.

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 1

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
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Figure 2

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

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Comparison 1 Antibiotics use, Outcome 1 Antibiotics prescribed in ED.
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Analysis 1.1

Comparison 1 Antibiotics use, Outcome 1 Antibiotics prescribed in ED.

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Comparison 1 Antibiotics use, Outcome 2 Sensitivity analysis per risk of bias.
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Analysis 1.2

Comparison 1 Antibiotics use, Outcome 2 Sensitivity analysis per risk of bias.

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Comparison 2 ED length of visit, Outcome 1 Mean ED length of visit in minutes.
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Analysis 2.1

Comparison 2 ED length of visit, Outcome 1 Mean ED length of visit in minutes.

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Comparison 2 ED length of visit, Outcome 2 Sensitivity analysis per risk of bias.
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Analysis 2.2

Comparison 2 ED length of visit, Outcome 2 Sensitivity analysis per risk of bias.

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Comparison 3 Laboratory investigations, Outcome 1 Blood investigations (cell count and/or cultures).
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Analysis 3.1

Comparison 3 Laboratory investigations, Outcome 1 Blood investigations (cell count and/or cultures).

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Comparison 3 Laboratory investigations, Outcome 2 Urine testing.
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Analysis 3.2

Comparison 3 Laboratory investigations, Outcome 2 Urine testing.

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Comparison 3 Laboratory investigations, Outcome 3 Blood investigation: sensitivity analysis per risk of bias.
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Analysis 3.3

Comparison 3 Laboratory investigations, Outcome 3 Blood investigation: sensitivity analysis per risk of bias.

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Comparison 3 Laboratory investigations, Outcome 4 Urine testing: sensitivity analysis per risk of bias.
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Analysis 3.4

Comparison 3 Laboratory investigations, Outcome 4 Urine testing: sensitivity analysis per risk of bias.

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Comparison 4 Chest radiography, Outcome 1 Chest radiography.
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Analysis 4.1

Comparison 4 Chest radiography, Outcome 1 Chest radiography.

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Comparison 4 Chest radiography, Outcome 2 Sensitivity analysis per risk of bias.
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Analysis 4.2

Comparison 4 Chest radiography, Outcome 2 Sensitivity analysis per risk of bias.

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Comparison 5 Visits to physician or ED post ED discharge, Outcome 1 Post ED discharge visit to MD.
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Analysis 5.1

Comparison 5 Visits to physician or ED post ED discharge, Outcome 1 Post ED discharge visit to MD.

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Comparison 1. Antibiotics use

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Antibiotics prescribed in ED Show forest plot

4

1590

Risk Ratio (M‐H, Random, 95% CI)

0.89 [0.71, 1.12]

2 Sensitivity analysis per risk of bias Show forest plot

3

890

Risk Ratio (M‐H, Random, 95% CI)

0.86 [0.61, 1.22]
Figuras y tablas -
Comparison 1. Antibiotics use
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Comparison 2. ED length of visit

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean ED length of visit in minutes Show forest plot

3

1290

Mean Difference (IV, Random, 95% CI)

‐10.61 [‐22.47, 1.25]

2 Sensitivity analysis per risk of bias Show forest plot

2

590

Mean Difference (IV, Random, 95% CI)

‐19.47 [‐51.38, 12.44]
Figuras y tablas -
Comparison 2. ED length of visit
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Comparison 3. Laboratory investigations

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Blood investigations (cell count and/or cultures) Show forest plot

4

1590

Risk Ratio (M‐H, Random, 95% CI)

0.79 [0.62, 1.00]

2 Urine testing Show forest plot

4

1588

Risk Ratio (M‐H, Random, 95% CI)

0.97 [0.79, 1.19]

3 Blood investigation: sensitivity analysis per risk of bias Show forest plot

3

888

Risk Ratio (M‐H, Random, 95% CI)

0.61 [0.42, 0.89]

4 Urine testing: sensitivity analysis per risk of bias Show forest plot

3

890

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.70, 1.25]
Figuras y tablas -
Comparison 3. Laboratory investigations
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Comparison 4. Chest radiography

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Chest radiography Show forest plot

4

1590

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.65, 0.91]

2 Sensitivity analysis per risk of bias Show forest plot

3

890

Odds Ratio (M‐H, Random, 95% CI)

0.59 [0.43, 0.81]
Figuras y tablas -
Comparison 4. Chest radiography
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Comparison 5. Visits to physician or ED post ED discharge

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Post ED discharge visit to MD Show forest plot

2

899

Risk Ratio (M‐H, Random, 95% CI)

1.00 [0.77, 1.29]
Figuras y tablas -
Comparison 5. Visits to physician or ED post ED discharge
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