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Cochrane Database of Systematic Reviews

Aislamiento como estrategia para el control de la transmisión de la infección por virus de la hepatitis C (HCV) en unidades de hemodiálisis

Información

DOI:
https://doi.org/10.1002/14651858.CD006420.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 11 agosto 2016see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Riñón y trasplante

Copyright:
  1. Copyright © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

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Contraer

Autores

  • Jessica I Bravo Zuñiga

    Correspondencia a: Universidad Peruana Cayetano Heredia, Lima, Peru

    [email protected]

    [email protected]

    Department of Nephrology, Hospital Edgardo Rebagliati, Lima, Peru

  • César Loza Munárriz

    Department of Nephrology, Universidad Peruana Cayetano Heredia, Lima, Peru

  • Jesús López‐Alcalde

    Unidad de bioestadística clínica, Hospital Universitario Ramón y Cajal (IRYCIS). CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

    Faculty of Medicine, Universidad Francisco de Vitoria (UFV) Madrid, Madrid, Spain

Contributions of authors

Writing of protocol and review: JB, CLM, JLA
Screening of titles and abstracts: JB, CLM, JLA
Assessment for inclusion: JB, CLM, JLA
Quality assessment: JB, CLM, JLA
Data extraction: JB, CLM
Data entry into RevMan: JB, CLM
Data analysis: JB, CLM, JLA

Sources of support

Internal sources

  • None known, Peru.

External sources

  • No sources of support supplied

Declarations of interest

  • Jessica I Bravo Zuñiga: none known

  • César Loza Munárriz: none known

  • Jesús López‐Alcalde: none known

Acknowledgements

We wish to acknowledge the Cochrane Kidney and Transplant editorial team and the referees for the comments and feedback during the preparation of this review.

Version history

Published

Title

Stage

Authors

Version

2016 Aug 11

Isolation as a strategy for controlling the transmission of hepatitis C virus (HCV) infection in haemodialysis units

Review

Jessica I Bravo Zuñiga, César Loza Munárriz, Jesús López‐Alcalde

https://doi.org/10.1002/14651858.CD006420.pub2

2007 Jan 24

Isolation as a strategy for controlling the transmission of hepatitis C virus (HCV) infection in haemodialysis units

Protocol

Jessica I Bravo Zuñiga, Cesar Loza Munarriz, Jesús López‐Alcalde

https://doi.org/10.1002/14651858.CD006420

Differences between protocol and review

Additional risk of bias assessments have been added due to the inclusion of cluster RCTs.

Keywords

MeSH

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

original image
Figuras y tablas -
Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across one included study.
Figuras y tablas -
Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across one included study.

Risk of bias summary: review authors' judgements about each risk of bias item for one included study.
Figuras y tablas -
Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for one included study.

Comparison 1 Dialysis machine separation vs Usual care, Outcome 1 Incidence of HCV infection: 9 months.
Figuras y tablas -
Analysis 1.1

Comparison 1 Dialysis machine separation vs Usual care, Outcome 1 Incidence of HCV infection: 9 months.

Comparison 1 Dialysis machine separation vs Usual care, Outcome 2 Incidence of HCV infection: 18 months.
Figuras y tablas -
Analysis 1.2

Comparison 1 Dialysis machine separation vs Usual care, Outcome 2 Incidence of HCV infection: 18 months.

Summary of findings for the main comparison. Dialysis machine separation versus usual care

Should patients with HCV be isolated in haemodialysis units for controlling the transmission of HCV?

Patient or population: patients in haemodialysis
Setting: ambulatory

Intervention: isolation
Comparison: usual care

Outcomes

Anticipated absolute effects* (95% CI)

Relative effect
(95% CI)

No. of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Risk with usual care

Risk with isolation

Incidence of HCV infection (9 months)

Study population

RR 0.34
(0.11 to 1.07)

446 (1)

⊕⊝⊝⊝
VERY LOW

Very low quality of evidence due to high risk of bias and imprecision

47 per 1.000

16 per 1.000
(5 to 50)

Incidence of HCV infection (18 months)

Study population

RR 0.22
(0.05 to 1.02)

281 (1)

⊕⊝⊝⊝
VERY LOW

Very low quality of evidence due to high risk of bias and imprecision

58 per 1.000

13 per 1.000
(3 to 59)

*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: Confidence interval; RR: Risk ratio

GRADE Working Group grades of evidence
High quality: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect

Figuras y tablas -
Summary of findings for the main comparison. Dialysis machine separation versus usual care
Comparison 1. Dialysis machine separation vs Usual care

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of HCV infection: 9 months Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Totals not selected

2 Incidence of HCV infection: 18 months Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 1. Dialysis machine separation vs Usual care