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Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
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Figure 1

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.1 Change in 6‐minute walk test immediately following training.
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Figure 2

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.1 Change in 6‐minute walk test immediately following training.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.2 6‐minute walk test at long‐term follow‐up. Mean change from baseline.
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Figure 3

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.2 6‐minute walk test at long‐term follow‐up. Mean change from baseline.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.3 VO2peak immediately following training ‐ ml.kg.min.
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Figure 4

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.3 VO2peak immediately following training ‐ ml.kg.min.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.4 Change in VEmax immediately following training ‐ Litres.min.
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Figure 5

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.4 Change in VEmax immediately following training ‐ Litres.min.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.5 Change in maximum heart rate immediately following training ‐ beats per minute.
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Figure 6

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.5 Change in maximum heart rate immediately following training ‐ beats per minute.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.6 Dyspnoea score immediately following training.
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Figure 7

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.6 Dyspnoea score immediately following training.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.7 Change in dyspnoea score at long‐term follow‐up.
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Figure 8

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.7 Change in dyspnoea score at long‐term follow‐up.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.8 Change in quality of life immediately following training.
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Figure 9

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.8 Change in quality of life immediately following training.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.9 Quality of life at long‐term follow up.
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Figure 10

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.9 Quality of life at long‐term follow up.

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Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.10 Six month survival.
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Figure 11

Forest plot of comparison: 1 Physical training vs no physical training, outcome: 1.10 Six month survival.

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Comparison 1 Physical training vs no physical training, Outcome 1 Change in 6‐minute walk distance immediately following training. Mean change from baseline ‐ metres.
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Analysis 1.1

Comparison 1 Physical training vs no physical training, Outcome 1 Change in 6‐minute walk distance immediately following training. Mean change from baseline ‐ metres.

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Comparison 1 Physical training vs no physical training, Outcome 2 Change in 6‐minute walk test at long‐term follow‐up. Mean change from baseline ‐ metres.
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Analysis 1.2

Comparison 1 Physical training vs no physical training, Outcome 2 Change in 6‐minute walk test at long‐term follow‐up. Mean change from baseline ‐ metres.

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Comparison 1 Physical training vs no physical training, Outcome 3 Change in VO2peak immediately following training ‐ ml.kg.min.
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Analysis 1.3

Comparison 1 Physical training vs no physical training, Outcome 3 Change in VO2peak immediately following training ‐ ml.kg.min.

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Comparison 1 Physical training vs no physical training, Outcome 4 Change in VEmax immediately following training ‐ Litres.min.
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Analysis 1.4

Comparison 1 Physical training vs no physical training, Outcome 4 Change in VEmax immediately following training ‐ Litres.min.

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Comparison 1 Physical training vs no physical training, Outcome 5 Change in maximum heart rate immediately following training ‐ beats per minute.
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Analysis 1.5

Comparison 1 Physical training vs no physical training, Outcome 5 Change in maximum heart rate immediately following training ‐ beats per minute.

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Comparison 1 Physical training vs no physical training, Outcome 6 Change in dyspnoea score immediately following training.
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Analysis 1.6

Comparison 1 Physical training vs no physical training, Outcome 6 Change in dyspnoea score immediately following training.

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Comparison 1 Physical training vs no physical training, Outcome 7 Change in dyspnoea score at long‐term follow‐up.
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Analysis 1.7

Comparison 1 Physical training vs no physical training, Outcome 7 Change in dyspnoea score at long‐term follow‐up.

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Comparison 1 Physical training vs no physical training, Outcome 8 Change in quality of life immediately following training.
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Analysis 1.8

Comparison 1 Physical training vs no physical training, Outcome 8 Change in quality of life immediately following training.

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Comparison 1 Physical training vs no physical training, Outcome 9 Change in quality of life at long‐term follow‐up.
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Analysis 1.9

Comparison 1 Physical training vs no physical training, Outcome 9 Change in quality of life at long‐term follow‐up.

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Comparison 1 Physical training vs no physical training, Outcome 10 Six month survival.
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Analysis 1.10

Comparison 1 Physical training vs no physical training, Outcome 10 Six month survival.

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Comparison 1. Physical training vs no physical training

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in 6‐minute walk distance immediately following training. Mean change from baseline ‐ metres Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 All participants

2

85

Mean Difference (IV, Fixed, 95% CI)

38.61 [15.37, 61.85]

1.2 Idiopathic pulmonary fibrosis only

2

62

Mean Difference (IV, Fixed, 95% CI)

26.55 [2.81, 50.30]

1.3 Severe lung disease

1

23

Mean Difference (IV, Fixed, 95% CI)

9.61 [‐29.43, 48.65]

1.4 Desaturators

1

30

Mean Difference (IV, Fixed, 95% CI)

15.62 [‐15.93, 47.17]

2 Change in 6‐minute walk test at long‐term follow‐up. Mean change from baseline ‐ metres Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 All participants

1

57

Mean Difference (IV, Fixed, 95% CI)

7.40 [‐36.42, 51.22]

2.2 Idiopathic pulmonary fibrosis only

1

34

Mean Difference (IV, Fixed, 95% CI)

‐23.08 [‐70.59, 24.43]

2.3 Severe lung disease

1

23

Mean Difference (IV, Fixed, 95% CI)

13.49 [‐62.30, 89.28]

2.4 Desaturators

1

30

Mean Difference (IV, Fixed, 95% CI)

‐22.24 [‐89.85, 45.37]

3 Change in VO2peak immediately following training ‐ ml.kg.min Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 All participants

1

52

Mean Difference (IV, Fixed, 95% CI)

0.69 [‐0.25, 1.63]

3.2 Idiopathic pulmonary fibrosis only

1

30

Mean Difference (IV, Fixed, 95% CI)

0.7 [‐0.52, 1.92]

3.3 Severe lung disease

1

18

Mean Difference (IV, Fixed, 95% CI)

‐0.03 [‐89.86, 89.80]

3.4 Desaturators

1

27

Mean Difference (IV, Fixed, 95% CI)

0.84 [‐0.31, 1.99]

4 Change in VEmax immediately following training ‐ Litres.min Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 All participants

1

52

Mean Difference (IV, Fixed, 95% CI)

4.71 [0.10, 9.32]

4.2 Idiopathic pulmonary fibrosis only

1

30

Mean Difference (IV, Fixed, 95% CI)

6.97 [0.87, 13.07]

4.3 Severe lung disease

1

20

Mean Difference (IV, Fixed, 95% CI)

4.16 [‐3.34, 11.66]

4.4 Desaturators

1

27

Mean Difference (IV, Fixed, 95% CI)

6.95 [0.03, 13.87]

5 Change in maximum heart rate immediately following training ‐ beats per minute Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

5.1 All participants

1

52

Mean Difference (IV, Fixed, 95% CI)

‐1.84 [‐6.26, 2.58]

5.2 Idiopathic pulmonary fibrosis only

1

30

Mean Difference (IV, Fixed, 95% CI)

‐1.91 [‐5.92, 2.10]

5.3 Severe lung disease

1

20

Mean Difference (IV, Fixed, 95% CI)

‐5.38 [‐11.46, 0.70]

5.4 Desaturators

1

27

Mean Difference (IV, Fixed, 95% CI)

‐0.45 [‐6.07, 5.17]

6 Change in dyspnoea score immediately following training Show forest plot

2

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

6.1 All participants

2

85

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.47 [‐0.91, ‐0.04]

6.2 Idiopathic pulmonary fibrosis only

2

62

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.43 [‐0.94, 0.08]

6.3 Severe lung disease

1

23

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.70 [‐1.56, 0.15]

6.4 Desaturators

1

30

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.85 [‐1.61, ‐0.09]

7 Change in dyspnoea score at long‐term follow‐up Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

7.1 All participants

1

57

Mean Difference (IV, Fixed, 95% CI)

‐0.13 [‐0.81, 0.55]

7.2 Idiopathic pulmonary fibrosis only

1

34

Mean Difference (IV, Fixed, 95% CI)

0.01 [‐0.79, 0.81]

7.3 Severe lung disease

1

23

Mean Difference (IV, Fixed, 95% CI)

‐0.12 [‐1.23, 0.99]

7.4 Desaturators

1

30

Mean Difference (IV, Fixed, 95% CI)

0.20 [‐0.84, 1.24]

8 Change in quality of life immediately following training Show forest plot

2

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

8.1 All participants

2

85

Std. Mean Difference (IV, Fixed, 95% CI)

0.58 [0.15, 1.02]

8.2 Idiopathic pulmonary fibrosis only

2

62

Std. Mean Difference (IV, Fixed, 95% CI)

0.57 [0.06, 1.09]

8.3 Severe lung disease

1

23

Std. Mean Difference (IV, Fixed, 95% CI)

0.86 [‐0.00, 1.73]

8.4 Desaturators

1

30

Std. Mean Difference (IV, Fixed, 95% CI)

0.42 [‐0.31, 1.15]

9 Change in quality of life at long‐term follow‐up Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

9.1 All participants

1

57

Mean Difference (IV, Fixed, 95% CI)

8.78 [‐2.18, 19.74]

9.2 Idiopathic pulmonary fibrosis only

1

34

Mean Difference (IV, Fixed, 95% CI)

7.05 [‐8.29, 22.39]

9.3 Severe lung disease

1

23

Mean Difference (IV, Fixed, 95% CI)

14.93 [0.54, 29.32]

9.4 Desaturators

1

30

Mean Difference (IV, Fixed, 95% CI)

3.66 [‐13.35, 20.67]

10 Six month survival Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

10.1 All participants

1

57

Odds Ratio (M‐H, Fixed, 95% CI)

0.89 [0.12, 6.82]

10.2 Idiopathic pulmonary fibrosis only

1

34

Odds Ratio (M‐H, Fixed, 95% CI)

0.67 [0.08, 5.40]

10.3 Severe lung disease

1

23

Odds Ratio (M‐H, Fixed, 95% CI)

1.64 [0.13, 21.10]

10.4 Desaturators

1

30

Odds Ratio (M‐H, Fixed, 95% CI)

1.6 [0.13, 19.84]
Figuras y tablas -
Comparison 1. Physical training vs no physical training
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