Appendix 1. Search strategies

CENTRAL

#1 MeSH descriptor: [Vomiting] explode all trees

#2 MeSH descriptor: [Nausea] explode all trees

#3 vomit*:ti,ab,kw (Word variations have been searched)

#4 nause*:ti,ab,kw (Word variations have been searched)

#5 (emesis or emet*):ti,ab,kw (Word variations have been searched)

#6 (antiemet* or anti‐emet*):ti,ab,kw (Word variations have been searched)

#7 #1 or #2 or #3 or #4 or #5 or #6

#8 MeSH descriptor: [Haloperidol] this term only

#9 (haloperidol or enabran* or halopidol* or halozen* or limerix* or neupram* or zetoridal* or haldol* or serenace* or haloper* or loperidol* or "uni haloper*" or novo‐peridol* or peridol* or alternus* or serenase* or buteridol* or duraperidol* or elaubat* or haloneural* or sigaperidol* or aloperidin* or sevium$.mp. or cizoren* or pericate* or peridor* or bioperidol* or kepsidol* or pulsit* or serenelfi*):ti,ab,kw (Word variations have been searched)

#10 (senorm* or cereen* or h‐tab* or halo‐p or halomed* or halopol* or haricon* or haridol* or perida* or polyhadon* or schizopol* or tensidol* or dozic* or fortunan* or halperon*):ti,ab,kw (Word variations have been searched)

#11 butyrophenone*:ti,ab,kw (Word variations have been searched)

#12 MeSH descriptor: [Butyrophenones] explode all trees

#13 #8 or #9 or #10 or #11 or #12

MEDLINE

1. RANDOMIZED CONTROLLED TRIAL.pt.
2. CONTROLLED CLINICAL TRIAL.pt.
3. RANDOMIZED CONTROLLED TRIALS.sh.
4. RANDOM ALLOCATION.sh.
5. DOUBLE BLIND METHOD.sh.
6. SINGLE BLIND METHOD.sh.
7. 1 or 2 or 3 or 4 or 5 or 6
8. (ANIMALS not HUMAN).sh.
9. 7 not 8
10. CLINICAL TRIAL.pt.
11. exp CLINICAL TRIALS/
12. (clin$ adj25 trial$).ti,ab.
13. ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$)).ti,ab.
14. PLACEBOS.sh.
15. placebo$.ti,ab.
16. random$.ti,ab.
17. RESEARCH DESIGN.sh.
18. 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17
19. 18 not 8
20. 19 not 9
21. COMPARATIVE STUDY.sh.
22. exp EVALUATION STUDIES/
23. FOLLOW UP STUDIES.sh.
24. PROSPECTIVE STUDIES.sh.
25. (control$ or prospectiv$ or volunteer$).ti,ab.
26. 21 or 22 or 23 or 24 or 25
27. 26 not 8
28. 27 not (9 or 20)
29. 9 or 20 or 28
30. nause$.mp.
31. vomit$.mp.
32. emesis.mp.
33. emet$.mp.
34. anti‐eme$.mp.
35. antieme$.mp.
36. antiemetics.sh.
37. nausea.sh.
38. vomiting.sh.
39. 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38
40. haloperidol.mp.
41. enabran$.mp.
42. halopidol$.mp.
43. halozen$.mp.
44. limerix$.mp.
45. neupram$.mp.
46. zetoridal$.mp.
47. haldol$.mp.
48. serenace$.mp.
49. haloper$.mp.
50. loperidol$.mp.
51. "uni haloper$".mp.
52. novo‐peridol$.mp.
53. peridol$.mp.
54. alternus$.mp.
55. serenase$.mp.
56. buteridol$.mp.
57. duraperidol$.mp.
58. elaubat$.mp.
59. haloneural$.mp.
60. sigaperidol$.mp.
61. aloperidin$.mp.
62. sevium$.mp.
63. cizoren$.mp.
64. pericate$.mp.
65. peridor$.mp.
66. bioperidol$.mp.
67. avant$.mp.
68. kepsidol$.mp.
69. pulsit$.mp.
70. serenelfi$.mp.
71. senorm$.mp.
72. cereen$.mp.
73. h‐tab$.mp.
74. halo‐p.mp.
75. halomed$.mp.
76. halopol$.mp.
77. haricon$.mp.
78. haridol$.mp.
79. perida$.mp.
80. polyhadon$.mp.
81. schizopol$.mp.
82. tensidol$.mp.
83. dozic$.mp.
84. fortunan$.mp.
85. halperon$.mp.
86. 40 or 41 or 42 or 43 or 44 or 45 or 46 or 47 or 48 or 49 or 50 or 51 or 52 or 53 or 54 or 55 or 56 or 57 or 58 or 59 or 60 or 61 or 62 or 63 or 64 or 65 or 66 or 67 or 68 or 69 or 70 or 71 or 72 or 73 or 74 or 75 or 76 or 77 or 78 or 79 or 80 or 81 or 82 or 83 or 84 or 85
87. butyrophenone$.mp.
88. exp butyrophenones/
89. 87 or 88
90. 86 or 89
91. 29 and 39 and 90

EMBASE

1 exp Vomiting/ (131250)
2 exp Nausea/ (152267)
3 vomit*.tw. (73323)
4 nause*.tw. (66297)
5 (emesis or emet*).tw. (12303)
6 (antiemet* or anti‐emet*).tw. (9283)
7 or/1‐6 (248098)
8 exp Butyrophenones/ (66670)
9 butyrophenone*.tw. (961)
10 (senorm* or cereen* or h‐tab* or halo‐p or halomed* or halopol* or haricon* or haridol* or perida* or polyhadon* or schizopol* or tensidol* or dozic* or fortunan* or halperon*).tw. (178)
11 (haloperidol or enabran* or halopidol* or halozen* or limerix* or neupram* or zetoridal* or haldol* or serenace* or haloper* or loperidol* or "uni haloper*" or novo‐peridol* or peridol* or alternus* or serenase* or buteridol* or duraperidol* or elaubat* or haloneural* or sigaperidol* or aloperidin* or sevium* or cizoren* or pericate* or peridor* or bioperidol* or kepsidol* or pulsit* or serenelfi*).tw. (22865)
12 or/8‐11 (68762)
13 random$.tw. (927492)
14 factorial$.tw. (24183)
15 crossover$.tw. (50980)
16 cross over$.tw. (22914)
17 cross‐over$.tw. (22914)
18 placebo$.tw. (209888)
19 (doubl$ adj blind$).tw. (151391)
20 (singl$ adj blind$).tw. (15179)
21 assign$.tw. (249822)
22 allocat$.tw. (88369)
23 volunteer$.tw. (186012)
24 Crossover Procedure/ (40652)
25 double‐blind procedure.tw. (222)
26 Randomized Controlled Trial/ (355913)
27 Single Blind Procedure/ (19061)
28 or/13‐27 (1477437)
29 (animal/ or nonhuman/) not human/ (4687675)
30 28 not 29 (1306909)
31 7 and 12 and 30 (1217)
32 (201311* or 201312* or 2014*).dd. (1574688)
33 31 and 32 (34)

CINAHL

S13 S7 AND S12

S12 S8 OR S9 OR S10 OR S11

S11 (haloperidol or enabran* or halopidol* or halozen* or limerix* or neupram* or zetoridal* or haldol* or serenace* or haloper* or loperidol* or "uni haloper*" or novo‐peridol* or peridol* or alternus* or serenase* or buteridol* or duraperidol* or elaubat* or haloneural* or sigaperidol* or aloperidin* or sevium* or cizoren* or pericate* or peridor* or bioperidol* or kepsidol* or pulsit* or serenelfi*)

S10 (senorm* or cereen* or h‐tab* or halo‐p or halomed* OR halopol* OR haricon* or haridol* or perida* or polyhadon* or schizopol* or tensidol* or dozic* or fortunan* or halperon*)

S9 butyrophenone*

S8 (MH "Antipsychotic Agents, Butyrophenone+")

S7 S1 OR S2 OR S3 OR S4 OR S5 OR S6

S6 (antiemet* or anti‐emet*)

S5 (emesis or emet*)

S4 nause*

S3 vomit*

S2 (MH "Nausea")

S1 (MH "Vomiting+")

AMED

1. exp Vomiting/

2. exp Nausea/

3. vomit*.tw.

4. nause*.tw.

5. (emesis or emet*).tw.

6. (antiemet* or anti‐emet*).tw.

7. or/1‐6

8. butyrophenone*.tw.

9. (senorm* or cereen* or h‐tab* or halo‐p or halomed* or halopol* or haricon* or haridol* or perida* or polyhadon* or schizopol* or tensidol* or dozic* or fortunan* or halperon*).tw.

10. (haloperidol or enabran* or halopidol* or halozen* or limerix* or neupram* or zetoridal* or haldol* or serenace* or haloper* or loperidol* or "uni haloper*" or novo‐peridol* or peridol* or alternus* or serenase* or buteridol* or duraperidol* or elaubat* or haloneural* or sigaperidol* or aloperidin* or sevium* or cizoren* or pericate* or peridor* or bioperidol* or kepsidol* or pulsit* or serenelfi*).tw.

11. or/8‐10

12. 7 and 11