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Figure 1
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Comparison 1 TCHM versus control, Outcome 1 Treatment success rate.
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Analysis 1.1

Comparison 1 TCHM versus control, Outcome 1 Treatment success rate.

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Comparison 1 TCHM versus control, Outcome 2 Time to cessation of abdominal pain (days).
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Analysis 1.2

Comparison 1 TCHM versus control, Outcome 2 Time to cessation of abdominal pain (days).

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Comparison 1 TCHM versus control, Outcome 3 Time to cessation of vaginal bleeding (days).
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Analysis 1.3

Comparison 1 TCHM versus control, Outcome 3 Time to cessation of vaginal bleeding (days).

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Comparison 1 TCHM versus control, Outcome 4 Time for serum beta‐hCG levels to return to normal (days).
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Analysis 1.4

Comparison 1 TCHM versus control, Outcome 4 Time for serum beta‐hCG levels to return to normal (days).

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Comparison 1 TCHM versus control, Outcome 5 Diminution of the ectopic pregnancy mass by ultrasound (mm).
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Analysis 1.5

Comparison 1 TCHM versus control, Outcome 5 Diminution of the ectopic pregnancy mass by ultrasound (mm).

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Comparison 1 TCHM versus control, Outcome 6 Duration of hospital stay (days).
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Analysis 1.6

Comparison 1 TCHM versus control, Outcome 6 Duration of hospital stay (days).

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Comparison 1 TCHM versus control, Outcome 7 Adverse events rate.
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Analysis 1.7

Comparison 1 TCHM versus control, Outcome 7 Adverse events rate.

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Table 1. Contents of the formulations used in included studies

Study ID

Content

Treating methods

Zhao 2000

Chi Shao10‐12g, Dan Shen 12‐15g, Tao Ren 6‐9g, Yuan Hu 10‐12g, San Leng 6‐9g, E Shu 6‐9g, Tian Hua Fen 20‐30g.

Once a day for 7‐10 days.

Li 2004c

Chi Shao 10g, Tao Ren 10g, Dan Shen 10g, San Leng 10g, E Shu 10g, Wu Gong 3 pieces, Tu Niu Xi 10g, Tian Hua Fen 30g, Yan Hu Suo 10g, Hou Pu 10g.

Once a day for 14 days.
Figuras y tablas -
Table 1. Contents of the formulations used in included studies
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Table 2. The names of Chinese herbs in different languages

Pingying name

Latin name

English name

E Shu

Rhizoma curcumae

Zedoray rhizome

Chi Shao

Radix paeoniae

Rubra

Hong Hua

Flos carthami

Safflower

Tian Hua Fen

Radix trichosanthis

Trichosanthin

Tao Ren

Semen persicae

Peach seed

Dang Gui

Radix angelicae sinensis

Chinese angelica

San Qi

Radix notoginseng

Sanchi

Wu Gong

Scolopendra

Centipede

Dan Shen

Ridx salviae miltiorrhiae

Danshen root

Yuan Hu

Corydalis tuber

San Leng

Rhizoma sparganii

Common burreed tuber

Lian Qiao

Fructus forsythiae

Weeping forsythia capsule

Zi Cao

Radix arnebiae

Arnebia root

Shuang Hua

Huang Bo

Cortex phellodendri

Amur cork‐tree

Xian He Cao

Herba agrimoniae

Hairyvein agrimonia herd

Tu Niu Xi

Twotooth achyranthes root

Yan Hu Suo

Rhizoma

Yanhusuo

Hou Pu

Magnoliae cortex

Magnolia bark
Figuras y tablas -
Table 2. The names of Chinese herbs in different languages
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Table 3. Risk of bias of the included studies

Study ID

Concealed allocation

Randomisation method

Complete follow up

Blinding

Prognosis balanced

Control group contamination

Any other bias

Zhao 2000

No

Random number table

No?

No

Yes

No

Unequal numbers on arms due to the discontinuation of the study

Li 2004c

No

Random number table

Yes?

Double blinding.

Yes

No
Figuras y tablas -
Table 3. Risk of bias of the included studies
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Comparison 1. TCHM versus control

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Treatment success rate Show forest plot

2

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

1.1 TCM versus WMD

1

56

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.59, 1.14]

1.2 TCM + WMD versus placebo + WMD or WMD only

1

70

Risk Ratio (M‐H, Fixed, 95% CI)

1.17 [0.97, 1.40]

1.3 TCM + WMD versus TCM

2

125

Risk Ratio (M‐H, Fixed, 95% CI)

1.33 [1.08, 1.63]

2 Time to cessation of abdominal pain (days) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 TCM + WMD versus TCM

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Time to cessation of vaginal bleeding (days) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 TCM + WMD versusTCM

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Time for serum beta‐hCG levels to return to normal (days) Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 TCM + WMD versus placebo + WMD or WMD only

1

70

Mean Difference (IV, Fixed, 95% CI)

‐6.68 [‐11.49, ‐1.87]

4.2 TCM + WMD versus TCM

2

125

Mean Difference (IV, Fixed, 95% CI)

‐8.12 [‐10.89, ‐5.35]

5 Diminution of the ectopic pregnancy mass by ultrasound (mm) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Diameter of the mass before treatment

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5.2 Diameter of the mass after treatment

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Duration of hospital stay (days) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 TCM versus WMD

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.2 TCM + WMD versus placebo + WMD or WMD only

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.3 TCM + WMD versus TCM

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Adverse events rate Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7.1 TCM versus WMD

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.2 TCM + WMD versus placebo + WMD or WMD only

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.3 TCM + WMD versus TCM

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. TCHM versus control
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