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Comparison 1 MSP/RESA vaccine versus placebo, Outcome 1 Parasite density.
Figuras y tablas -
Analysis 1.1

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 1 Parasite density.

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 2 Clinical malaria episodes.
Figuras y tablas -
Analysis 1.2

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 2 Clinical malaria episodes.

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 3 New malaria infection, by MSP2 type.
Figuras y tablas -
Analysis 1.3

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 3 New malaria infection, by MSP2 type.

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 4 Prevalence (microscopy).
Figuras y tablas -
Analysis 1.4

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 4 Prevalence (microscopy).

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 5 Prevalence (PCR), by MSP2 type.
Figuras y tablas -
Analysis 1.5

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 5 Prevalence (PCR), by MSP2 type.

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 6 Adverse events (any severity).
Figuras y tablas -
Analysis 1.6

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 6 Adverse events (any severity).

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 7 Adverse events (moderate severity).
Figuras y tablas -
Analysis 1.7

Comparison 1 MSP/RESA vaccine versus placebo, Outcome 7 Adverse events (moderate severity).

Comparison 1. MSP/RESA vaccine versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Parasite density Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 No sulfadoxine‐pyrimethamine pretreatment

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 Sulfadoxine‐pyrimethamine pretreatment

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Clinical malaria episodes Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2.1 No sulfadoxine‐pyrimethamine pretreatment

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 Sulfadoxine‐pyrimethamine pretreatment

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 New malaria infection, by MSP2 type Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 3D7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 FC27

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Prevalence (microscopy) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4.1 No sulfadoxine‐pyrimethamine

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Sulfadoxine‐pyrimethamine

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Prevalence (PCR), by MSP2 type Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5.1 3D7

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5.2 FC27

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Adverse events (any severity) Show forest plot

3

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

6.1 Pain at injection site

3

295

Risk Ratio (M‐H, Fixed, 95% CI)

0.99 [0.82, 1.20]

6.2 Limping gait

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.81 [0.41, 1.61]

6.3 Firmness/nodule at injection site

3

297

Risk Ratio (M‐H, Fixed, 95% CI)

1.35 [0.65, 2.79]

6.4 Swelling/induration at injection site

3

297

Risk Ratio (M‐H, Fixed, 95% CI)

1.58 [0.67, 3.74]

6.5 Fever

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.46, 1.45]

6.6 Cough

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

1.2 [0.38, 3.83]

6.7 Headache

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

1.25 [0.34, 4.54]

6.8 Pain

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.11, 3.92]

6.9 Vomiting

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

4.0 [0.45, 35.27]

6.10 Swelling

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [0.18, 21.76]

6.11 Conjunctivitis

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.12, 72.91]

6.12 Diarrhoea

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 8.10]

6.13 Difficulty hearing

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 8.10]

6.14 Earache

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 8.10]

6.15 Nausea

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

1.0 [0.06, 15.80]

6.16 Running nose

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 8.10]

7 Adverse events (moderate severity) Show forest plot

2

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

7.1 Fever

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

1.0 [0.06, 15.80]

7.2 Pain at injection site

2

273

Risk Ratio (M‐H, Fixed, 95% CI)

1.25 [0.49, 3.15]

7.3 Swelling at injection site

1

240

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 8.10]

Figuras y tablas -
Comparison 1. MSP/RESA vaccine versus placebo