Timing of prophylactic uterotonics for the third stage of labour after vaginal birth

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Analysis 1.1

Comparison 1 Timing of oxytocics, Outcome 1 Incidence of postpartum haemorrhage (blood loss > 500 ml).

Analysis 1.2

Comparison 1 Timing of oxytocics, Outcome 2 Blood loss (BL) (ml) (estimated or measured).

Analysis 1.3

Comparison 1 Timing of oxytocics, Outcome 3 Retained placenta.

Analysis 1.4

Comparison 1 Timing of oxytocics, Outcome 4 Length of 3rd stage of labour (mins).

Analysis 1.5

Comparison 1 Timing of oxytocics, Outcome 5 Haemoglobin changes (before and after birth, the time interval as decided by each article).

Analysis 1.6

Comparison 1 Timing of oxytocics, Outcome 6 Blood transfusion.

Analysis 1.7

Comparison 1 Timing of oxytocics, Outcome 7 Use of additional uterotonics.

Analysis 1.8

Comparison 1 Timing of oxytocics, Outcome 8 Incidence of severe postpartum haemorrhage (PPH => 1000 ml).

Analysis 1.9

Comparison 1 Timing of oxytocics, Outcome 9 Incidence of hypotension.

Comparison 1. Timing of oxytocics

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of postpartum haemorrhage (blood loss > 500 ml) Show forest plot	3	1667	Risk Ratio (IV, Fixed, 95% CI)	0.81 [0.62, 1.04]

2 Blood loss (BL) (ml) (estimated or measured) Show forest plot	2	181	Mean Difference (IV, Fixed, 95% CI)	22.32 [‐58.21, 102.86]

3 Retained placenta Show forest plot	3	1667	Risk Ratio (IV, Fixed, 95% CI)	1.54 [0.76, 3.11]

4 Length of 3rd stage of labour (mins) Show forest plot	3	1667	Mean Difference (IV, Fixed, 95% CI)	‐0.30 [‐0.95, 0.36]

5 Haemoglobin changes (before and after birth, the time interval as decided by each article) Show forest plot	1	51	Mean Difference (IV, Fixed, 95% CI)	0.06 [‐0.60, 0.72]

6 Blood transfusion Show forest plot	3	1667	Risk Ratio (IV, Fixed, 95% CI)	0.79 [0.23, 2.73]

7 Use of additional uterotonics Show forest plot	3	1667	Risk Ratio (IV, Fixed, 95% CI)	1.10 [0.80, 1.52]

8 Incidence of severe postpartum haemorrhage (PPH => 1000 ml) Show forest plot	1	130	Risk Ratio (IV, Fixed, 95% CI)	0.98 [0.48, 1.98]

9 Incidence of hypotension Show forest plot	1	130	Risk Ratio (IV, Fixed, 95% CI)	2.48 [0.23, 26.70]

Comparison 1. Timing of oxytocics