Short‐course versus long‐course antibiotic therapy for non‐severe community‐acquired pneumonia in children aged 2 months to 59 months

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Figure 1

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

Figure 2

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

Figure 3

Forest plot of comparison: 1 3 days versus 5 days treatment with the same antibiotic, outcome: 1.1 Clinical cure.

Figure 4

Forest plot of comparison: 1 3 days versus 5 days treatment with the same antibiotic, outcome: 1.2 Treatment failure.

Figure 5

Forest plot of comparison: 1 3 days versus 5 days treatment with the same antibiotic, outcome: 1.3 Relapse rate.

Analysis 1.1

Comparison 1 3 days versus 5 days treatment with the same antibiotic, Outcome 1 Clinical cure.

Analysis 1.2

Comparison 1 3 days versus 5 days treatment with the same antibiotic, Outcome 2 Treatment failure.

Analysis 1.3

Comparison 1 3 days versus 5 days treatment with the same antibiotic, Outcome 3 Relapse rate.

Comparison 1. 3 days versus 5 days treatment with the same antibiotic

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinical cure Show forest plot	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

1.1 All	3	5763	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.97, 1.01]
1.2 3 versus 5 days amoxicillin therapy	2	4012	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.97, 1.01]
1.3 3 versus 5 days cotrimoxazole therapy	1	1751	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.97, 1.03]
2 Treatment failure Show forest plot	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

2.1 All	3	5763	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.92, 1.25]
2.2 3 versus 5 days amoxicillin therapy	2	4012	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.94, 1.33]
2.3 3 versus 5 days cotrimoxazole therapy	1	1751	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.72, 1.30]
3 Relapse rate Show forest plot	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only

3.1 All	4	5469	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.84, 1.42]
3.2 3 versus 5 days amoxicillin therapy	2	3577	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.69, 1.60]
3.3 3 versus 5 days cotrimoxazole therapy	2	1892	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.80, 1.58]

Comparison 1. 3 days versus 5 days treatment with the same antibiotic