1 Death Show forest plot

6

1938

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.51, 0.75]

2 Death: time since admission to hospital [subgroup analysis] Show forest plot

3

3292

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.52, 0.81]

2.1 Death within 48 h

3

1646

Risk Ratio (M‐H, Fixed, 95% CI)

0.78 [0.57, 1.05]

2.2 Death after 48 h

3

1646

Risk Ratio (M‐H, Fixed, 95% CI)

0.53 [0.38, 0.74]

3 Death: allocation concealment [subgroup analysis] Show forest plot

6

1938

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.51, 0.75]

3.1 Adequate allocation concealment

4

1784

Risk Ratio (M‐H, Fixed, 95% CI)

0.63 [0.51, 0.77]

3.2 Inadequate allocation concealment

2

154

Risk Ratio (M‐H, Fixed, 95% CI)

0.46 [0.22, 0.97]

4 Death: cerebral malaria [subgroup analysis] Show forest plot

6

1938

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.51, 0.75]

4.1 All participants have cerebral malaria

3

292

Risk Ratio (M‐H, Fixed, 95% CI)

0.44 [0.25, 0.78]

4.2 Severe malaria

3

1646

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.52, 0.80]

5 Death: loading dose vs no loading dose of quinine [subgroup analysis] Show forest plot

6

1938

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.51, 0.75]

5.1 No loading dose

2

251

Risk Ratio (M‐H, Fixed, 95% CI)

0.47 [0.25, 0.87]

5.2 Loading dose

4

1687

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.52, 0.78]

6 Death: participant age [subgroup analysis] Show forest plot

6

1938

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.51, 0.75]

6.1 Adults (15/16 years +)

4

405

Risk Ratio (M‐H, Fixed, 95% CI)

0.47 [0.29, 0.75]

6.2 Children 2 to 15 years

1

72

Risk Ratio (M‐H, Fixed, 95% CI)

0.76 [0.22, 2.59]

6.3 All ages

1

1461

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.52, 0.81]

7 Death: intravenous vs intramuscular artesunate [subgroup analysis] Show forest plot

6

1938

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.51, 0.75]

7.1 Intravenous artesunate

5

1866

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.50, 0.75]

7.2 Intramuscular artesunate

1

72

Risk Ratio (M‐H, Fixed, 95% CI)

0.76 [0.22, 2.59]

8 Neurological sequelae at discharge Show forest plot

2

1253

Risk Ratio (M‐H, Fixed, 95% CI)

2.21 [0.64, 7.63]

9 Coma recovery time Show forest plot

2

231

Mean Difference (IV, Random, 95% CI)

2.11 [‐19.17, 23.40]

10 Time to hospital discharge Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

11 Fever clearance time Show forest plot

2

251

Mean Difference (IV, Random, 95% CI)

‐13.58 [‐55.09, 27.92]

12 Parasite clearance time of 50% Show forest plot

3

292

Mean Difference (IV, Random, 95% CI)

‐8.14 [‐11.55, ‐4.73]

13 Hypoglycaemia Show forest plot

3

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

13.1 Routine monitoring

2

185

Risk Ratio (M‐H, Fixed, 95% CI)

0.46 [0.25, 0.87]

13.2 Clinical monitoring

1

1461

Risk Ratio (M‐H, Fixed, 95% CI)

0.32 [0.13, 0.79]