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Cochrane Database of Systematic Reviews

تاثیر مکمل گلوتامین در کودکان خردسال مبتلا به بیماری شدید گوارشی

Información

DOI:
https://doi.org/10.1002/14651858.CD005947.pub4Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 15 diciembre 2014see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Neonatología

Copyright:
  1. Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

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Contraer

Autores

  • Jennifer VE Brown

    Centre for Reviews and Dissemination, University of York, York, UK

  • Thirimon Moe‐Byrne

    Centre for Reviews and Dissemination, University of York, York, UK

  • William McGuire

    Correspondencia a: Hull York Medical School & Centre for Reviews and Dissemination, University of York, York, UK

    [email protected]

Contributions of authors

In discussion with WM, JVEB searched and screened the studies for inclusion, assessed the methodological quality of the trials, and extracted and entered the relevant information and data from each included study. WM and JVEB completed the final review.

Sources of support

Internal sources

  • University of York, UK.

External sources

  • National Institute for Health Research (NIHR), UK.

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA.

    Editorial support of the Cochrane Neonatal Review Group has been funded with Federal funds from the Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA, under Contract No. HHSN275201100016C

Declarations of interest

None.

Acknowledgements

We thank Mellisa Harden (Centre for Reviews and Dissemination, University of York) for revising and running the electronic search.

We thank Professor Christopher Duggan for supporting a previous version of this review by providing further details about his trial (Duggan 2004), Professor Satish Kalhan for sharing data and for advising on glutamine metabolic studies in young infants, and Drs. Tubman and Zubin Grover for contributing to a previous iteration (Grover 2007).

Version history

Published

Title

Stage

Authors

Version

2014 Dec 15

Glutamine supplementation for young infants with severe gastrointestinal disease

Review

Jennifer VE Brown, Thirimon Moe‐Byrne, William McGuire

https://doi.org/10.1002/14651858.CD005947.pub4

2012 Jul 11

Glutamine supplementation for young infants with severe gastrointestinal disease

Review

Jennifer VE Wagner, Thirimon Moe‐Byrne, Zubin Grover, William McGuire

https://doi.org/10.1002/14651858.CD005947.pub3

2007 Jan 24

Glutamine supplementation for young infants with severe gastrointestinal disease

Review

Zubin Grover, Richard Tubman, William McGuire

https://doi.org/10.1002/14651858.CD005947.pub2

2006 Apr 19

Glutamine supplementation for young infants with severe gastrointestinal disease

Protocol

Zubin Grover, Richard TRJ Tubman, William McGuire

https://doi.org/10.1002/14651858.CD005947

Differences between protocol and review

Albers 2005 enrolled 80 children of gestational age at birth > 30 weeks and chronological age less than two years. This trial therefore did not strictly fulfil our a priori population criterion (infants up to three months old). However, we decided to include the trial because the report stated that most (69 of the 80) participants were less than six months old at enrolment. The report did not provide subgroup data for infants up to three months old.

Keywords

MeSH

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Forest plot of comparison 1: glutamine supplementation (parenteral or enteral) versus no supplementation, outcome 1.1: death prior to hospital discharge.
Figuras y tablas -
Figure 1

Forest plot of comparison 1: glutamine supplementation (parenteral or enteral) versus no supplementation, outcome 1.1: death prior to hospital discharge.

Forest plot of comparison 1: glutamine supplementation (parenteral or enteral) versus no supplementation, outcome 1.2: incidence of invasive infection.
Figuras y tablas -
Figure 2

Forest plot of comparison 1: glutamine supplementation (parenteral or enteral) versus no supplementation, outcome 1.2: incidence of invasive infection.

Forest plot of comparison 1: glutamine supplementation (parenteral or enteral) versus no supplementation, outcome 1.3: weight gain during trial period (g/day).
Figuras y tablas -
Figure 3

Forest plot of comparison 1: glutamine supplementation (parenteral or enteral) versus no supplementation, outcome 1.3: weight gain during trial period (g/day).

Comparison 1 Glutamine supplementation (parenteral or enteral) versus no supplementation, Outcome 1 Death prior to hospital discharge.
Figuras y tablas -
Analysis 1.1

Comparison 1 Glutamine supplementation (parenteral or enteral) versus no supplementation, Outcome 1 Death prior to hospital discharge.

Comparison 1 Glutamine supplementation (parenteral or enteral) versus no supplementation, Outcome 2 Incidence of invasive infection.
Figuras y tablas -
Analysis 1.2

Comparison 1 Glutamine supplementation (parenteral or enteral) versus no supplementation, Outcome 2 Incidence of invasive infection.

Comparison 1 Glutamine supplementation (parenteral or enteral) versus no supplementation, Outcome 3 Weight gain during trial period (g/day).
Figuras y tablas -
Analysis 1.3

Comparison 1 Glutamine supplementation (parenteral or enteral) versus no supplementation, Outcome 3 Weight gain during trial period (g/day).

Comparison 1. Glutamine supplementation (parenteral or enteral) versus no supplementation

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death prior to hospital discharge Show forest plot

3

263

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.19, 3.20]

2 Incidence of invasive infection Show forest plot

3

263

Risk Ratio (M‐H, Fixed, 95% CI)

1.37 [0.89, 2.11]

3 Weight gain during trial period (g/day) Show forest plot

1

20

Mean Difference (IV, Fixed, 95% CI)

3.80 [‐6.65, 14.25]

Figuras y tablas -
Comparison 1. Glutamine supplementation (parenteral or enteral) versus no supplementation