Progestogen for treating threatened miscarriage

Scolaris Content Display Scolaris Content Display

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Analysis 1.1

Comparison 1 Progesterone versus placebo or no treatment, Outcome 1 Miscarriage.

Analysis 1.2

Comparison 1 Progesterone versus placebo or no treatment, Outcome 2 Preterm labour.

Analysis 1.3

Comparison 1 Progesterone versus placebo or no treatment, Outcome 3 Congential abnormalities.

Analysis 1.4

Comparison 1 Progesterone versus placebo or no treatment, Outcome 4 Pregnancy‐induced hypertension.

Analysis 1.5

Comparison 1 Progesterone versus placebo or no treatment, Outcome 5 Antepartum haemorrhage.

Comparison 1. Progesterone versus placebo or no treatment

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Miscarriage Show forest plot	4	421	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.35, 0.79]

1.1 Oral progestogen versus no treatment	2	337	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.35, 0.84]
1.2 Vaginal progesterone versus placebo	2	84	Risk Ratio (M‐H, Fixed, 95% CI)	0.47 [0.17, 1.30]
2 Preterm labour Show forest plot	2	337	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.48, 2.52]

3 Congential abnormalities Show forest plot	2	337	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.10, 4.82]

4 Pregnancy‐induced hypertension Show forest plot	2	337	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.54, 1.88]

5 Antepartum haemorrhage Show forest plot	2	337	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.30, 1.94]

Comparison 1. Progesterone versus placebo or no treatment