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Study flow diagram.
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Figure 1

Study flow diagram.

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Comparison 1 Fluid restricted compared to liberal fluids, Outcome 1 Duration of hospitalisation.
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Analysis 1.1

Comparison 1 Fluid restricted compared to liberal fluids, Outcome 1 Duration of hospitalisation.

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Comparison 1 Fluid restricted compared to liberal fluids, Outcome 2 Daily weight gain.
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Analysis 1.2

Comparison 1 Fluid restricted compared to liberal fluids, Outcome 2 Daily weight gain.

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Comparison 1 Fluid restricted compared to liberal fluids, Outcome 3 Proportion with apnoea.
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Analysis 1.3

Comparison 1 Fluid restricted compared to liberal fluids, Outcome 3 Proportion with apnoea.

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Summary of findings for the main comparison. Fluid restricted compared to liberal fluids compared to placebo for treatment of preterm babies with chronic lung disease

Fluid restricted compared to liberal fluids compared to placebo for treatment of preterm babies with chronic lung disease

Participant or population: treatment of preterm babies with chronic lung disease
Setting:
Intervention: Fluid restricted compared to liberal fluids
Comparison: placebo

Outcomes

Anticipated absolute effects* (95% CI)

Relative effect
(95% CI)

№ of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Risk with placebo

Risk with fluid restricted compared to liberal fluids

Duration of oxygen therapy

The mean duration of oxygen therapy was 27.5 days

median 0.5 days higher
(0 to 0 )

‐

60
(1 RCT)

⊕⊕⊝⊝
LOW 1 2

Duration of hospitalisation

The mean duration of hospitalisation was 85 days

MD 3 Days higher
(7.64 lower to 13.64 higher)

‐

60
(1 RCT)

⊕⊕⊝⊝
LOW 1 2

Daily weight gain

The mean daily weight gain was 14.8 g/kg/d

MD 0.5 g/kg/d higher
(1.22 lower to 2.22 higher)

‐

60
(1 RCT)

⊕⊕⊝⊝
LOW 1 2

Proportion with apnoea

Study population

RR 1.35
(0.98 to 1.86)

60
(1 RCT)

⊕⊕⊝⊝
LOW 1 2

630 per 1000

850 per 1000
(617 to 1000)

Moderate

630 per 1000

850 per 1000
(617 to 1000)

*The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: Confidence interval; RR: Risk ratio; OR: Odds ratio

GRADE Working Group grades of evidence
High quality: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate quality: We are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low quality: Our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect
Very low quality: We have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect

1 Unmasked study

2 Wide confidence limits

Figuras y tablas -
Summary of findings for the main comparison. Fluid restricted compared to liberal fluids compared to placebo for treatment of preterm babies with chronic lung disease
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Comparison 1. Fluid restricted compared to liberal fluids

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Duration of hospitalisation Show forest plot

1

60

Mean Difference (IV, Fixed, 95% CI)

3.0 [‐7.64, 13.64]

2 Daily weight gain Show forest plot

1

60

Mean Difference (IV, Fixed, 95% CI)

0.5 [‐1.22, 2.22]

3 Proportion with apnoea Show forest plot

1

60

Risk Difference (M‐H, Fixed, 95% CI)

0.22 [‐0.00, 0.44]
Figuras y tablas -
Comparison 1. Fluid restricted compared to liberal fluids
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