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Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
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Figure 1

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 1 Compliance with mask at one month (hours per night).
Figuras y tablas -
Analysis 1.1

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 1 Compliance with mask at one month (hours per night).

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 2 Arousal index (#/hour).
Figuras y tablas -
Analysis 1.2

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 2 Arousal index (#/hour).

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 3 Apnoea‐hypopnoea index (events/hour).
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Analysis 1.3

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 3 Apnoea‐hypopnoea index (events/hour).

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 4 Sleep efficiency (%).
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Analysis 1.4

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 4 Sleep efficiency (%).

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 5 Minimum oxygen saturation (%).
Figuras y tablas -
Analysis 1.5

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 5 Minimum oxygen saturation (%).

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 6 Epworth Sleepiness Scale.
Figuras y tablas -
Analysis 1.6

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 6 Epworth Sleepiness Scale.

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 7 Symptoms of OSA.
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Analysis 1.7

Comparison 1 Nasal mask versus Oral mask (Oracle), Outcome 7 Symptoms of OSA.

Comparison 2 Nasal mask versus Nasal pillows, Outcome 1 Percentage of days used (%).
Figuras y tablas -
Analysis 2.1

Comparison 2 Nasal mask versus Nasal pillows, Outcome 1 Percentage of days used (%).

Comparison 2 Nasal mask versus Nasal pillows, Outcome 2 Apnoea‐hypopnoea index (events/hour).
Figuras y tablas -
Analysis 2.2

Comparison 2 Nasal mask versus Nasal pillows, Outcome 2 Apnoea‐hypopnoea index (events/hour).

Comparison 2 Nasal mask versus Nasal pillows, Outcome 3 Satisfaction with mask (mm visual analogue scale).
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Analysis 2.3

Comparison 2 Nasal mask versus Nasal pillows, Outcome 3 Satisfaction with mask (mm visual analogue scale).

Comparison 2 Nasal mask versus Nasal pillows, Outcome 4 Epworth Sleepiness Scale.
Figuras y tablas -
Analysis 2.4

Comparison 2 Nasal mask versus Nasal pillows, Outcome 4 Epworth Sleepiness Scale.

Comparison 3 Nasal mask versus Face mask, Outcome 1 Compliance (hours/night).
Figuras y tablas -
Analysis 3.1

Comparison 3 Nasal mask versus Face mask, Outcome 1 Compliance (hours/night).

Comparison 3 Nasal mask versus Face mask, Outcome 2 Epworth Sleepiness Scale.
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Analysis 3.2

Comparison 3 Nasal mask versus Face mask, Outcome 2 Epworth Sleepiness Scale.

Table 1. Nasal mask versus Oral mask: Adverse effects ‐ Anderson 2003

Side Effects n = 21

Nasal CPAP

Oral CPAP

Dry mouth / throat

1

11

Excess salivation

0

5

Sore gums / lips

0

5

Skin irritation

0

2

Air leaks

2

2

Congested nose

3

2

Mask dislodgement

4

3

Pressure from straps / mask

4

0

Difficulty fitting mask

0

1

Claustrophobia

1

0

Figuras y tablas -
Table 1. Nasal mask versus Oral mask: Adverse effects ‐ Anderson 2003
Table 2. Nasal mask versus Oral mask: Adverse effects ‐ Khanna 2003

Side effects

Nasal mask

Oral mask

at one month (scale 1 worst ‐5 best)

mean +/‐ SD

mean +/‐ SD

Oral dryness

4.1 +/‐ 0.9

3.3 +/‐ 0.9

Nasal dryness

4.4 +/‐ 0.9

4.9 +/‐ 0.39

Nasal congestion

3.6 +/‐ 1.2

4.8 +/‐ 0.5

Gum pain

4.7 +/‐ 1.0

4.3 +/‐ 0.8

Air leaks

3.9 +/‐ 1.1

4.6 +/‐ 0.8

Figuras y tablas -
Table 2. Nasal mask versus Oral mask: Adverse effects ‐ Khanna 2003
Table 3. Table of advantages & disadvantages of interfaces

Type

Advantage

Disadvantage

Nasal Mask

Conventional CPAP interface which has been most frequently assessed in CPAP efficacy trials

Relatively cheap

Adverse effects: pressure from mask/straps, air leaks, mouth leaks, mask dislodgment, dry throat, mouth & nose, nasal congestion, epistaxis

Requires cumbersome headgear

Oracle oral mask

Strapless device, lack of headgear

Bypasses the nasal passages ‐ useful in patients with nasal obstruction or experiencing intolerable nasal symptoms on nasal CPAP

Fewer air leaks & nasal dryness or congestion compared to nasal masks

Comparable to conventional nasal masks in terms of: compliance at one month; polysomnographic measures (e.g.. arousal index, AHI, sleep efficiency & minimum oxygen saturation); Epworth Sleepiness Scale & OSA symptoms

Adverse effects: dry mouth or throat, sore lips & gums, excess salivation

All patients require heated humidification

Nasal pillows

Less contact with the face

Fewer overall adverse effects compared to nasal mask

Greater patient satisfaction than nasal mask

Expensive

Face mask

Useful for patients experiencing mouth leaks & nasal dryness with nasal CPAP

Better compliance with nasal mask

Expensive

Adverse effects: air leaks, red/sore eyes, claustrophobia, difficulty exhaling

Not as comfortable as nasal mask

Requires cumbersome headgear

Figuras y tablas -
Table 3. Table of advantages & disadvantages of interfaces
Comparison 1. Nasal mask versus Oral mask (Oracle)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Compliance with mask at one month (hours per night) Show forest plot

2

mean difference (Fixed, 95% CI)

0.17 [‐0.54, 0.87]

2 Arousal index (#/hour) Show forest plot

1

#/hour (Fixed, 95% CI)

Totals not selected

3 Apnoea‐hypopnoea index (events/hour) Show forest plot

1

events/hour (Fixed, 95% CI)

Totals not selected

4 Sleep efficiency (%) Show forest plot

1

% (Fixed, 95% CI)

Totals not selected

5 Minimum oxygen saturation (%) Show forest plot

1

% (Fixed, 95% CI)

Totals not selected

6 Epworth Sleepiness Scale Show forest plot

1

mean difference (Fixed, 95% CI)

Totals not selected

7 Symptoms of OSA Show forest plot

1

mean difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 1. Nasal mask versus Oral mask (Oracle)
Comparison 2. Nasal mask versus Nasal pillows

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Percentage of days used (%) Show forest plot

1

% (Fixed, 95% CI)

Totals not selected

2 Apnoea‐hypopnoea index (events/hour) Show forest plot

1

events/hour (Fixed, 95% CI)

Totals not selected

3 Satisfaction with mask (mm visual analogue scale) Show forest plot

1

mm VAS (Fixed, 95% CI)

Totals not selected

4 Epworth Sleepiness Scale Show forest plot

1

mean difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 2. Nasal mask versus Nasal pillows
Comparison 3. Nasal mask versus Face mask

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Compliance (hours/night) Show forest plot

1

hours/night (Fixed, 95% CI)

Totals not selected

2 Epworth Sleepiness Scale Show forest plot

1

mean difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 3. Nasal mask versus Face mask