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Comparison 1 Concurrent versus sequential (chemotherapy first), Outcome 1 Local recurrence.
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Analysis 1.1

Comparison 1 Concurrent versus sequential (chemotherapy first), Outcome 1 Local recurrence.

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Comparison 1 Concurrent versus sequential (chemotherapy first), Outcome 2 Distant metastases.
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Analysis 1.2

Comparison 1 Concurrent versus sequential (chemotherapy first), Outcome 2 Distant metastases.

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Comparison 1 Concurrent versus sequential (chemotherapy first), Outcome 3 Toxicity.
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Analysis 1.3

Comparison 1 Concurrent versus sequential (chemotherapy first), Outcome 3 Toxicity.

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Comparison 2 Radiotherapy then chemotherapy versus chemotherapy then radiotherapy, Outcome 1 Toxicity.
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Analysis 2.1

Comparison 2 Radiotherapy then chemotherapy versus chemotherapy then radiotherapy, Outcome 1 Toxicity.

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Table 1. Radiotherapy then chemotherapy versus chemotherapy then radiotherapy

Outcome

Number of trials

Sample Size

OR/HR (95% CI)

OR P‐value

Heterogen. P‐value

Overall survival

1

224

0.85 (0.51to 1.4)

0.52

N/A

Distant metastases

1

244

0.82 (0.49 to 1.36)

0.44

N/A
Figuras y tablas -
Table 1. Radiotherapy then chemotherapy versus chemotherapy then radiotherapy
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Comparison 1. Concurrent versus sequential (chemotherapy first)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Local recurrence Show forest plot

2

853

Odds Ratio (M‐H, Fixed, 95% CI)

1.30 [0.45, 3.77]

2 Distant metastases Show forest plot

2

853

Odds Ratio (M‐H, Fixed, 95% CI)

1.43 [0.86, 2.37]

3 Toxicity Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 Skin toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Oesophageal toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 Nausea and vomiting

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.4 Alopecia

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.5 Infection

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.6 Fever

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.7 Cardiac toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.8 Neutrophil toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.9 Platelet toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.10 Haematological toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Concurrent versus sequential (chemotherapy first)
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Comparison 2. Radiotherapy then chemotherapy versus chemotherapy then radiotherapy

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Toxicity Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 Skin toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 Subcutaneous toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.3 Pneumonitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.4 Neutropaenic sepsis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.5 Cardiac toxicity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.6 Lymphoedema

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.7 Brachial plexopathy

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 2. Radiotherapy then chemotherapy versus chemotherapy then radiotherapy
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