Adenosine compared with calcium channel antagonists for supraventricular tachycardia

Patient or population: patients with supraventricular tachycardia
Setting: emergency department
Intervention: adenosine
Comparison: calcium channel antagonists (CCAs)

Odds of reversion

OR 1.51

(0.85 to 2.68)

89.7%

92.9%
(88.1 to 95.9

3.2% lower odds of reversion with adenosine
(95% CI 1.2 lower to 6.2 lower)

Until reversion occurred
or predetermined maximum dose was reached

⊕⊕⊕⊝
MODERATE^a

Higher odds of reversion indicate better effect.

Major adverse event:
hypotension

OR 3.09
(0.12 to 76.71)

0.0%

0.0%

(0.0 to 0.0)

0.0% fewer

(0 fewer to 0 fewer)

Up to 2 hours after infusion

⊕⊕⊝⊝
LOW^a,b

Lower hypotension rate indicates fewer adverse events.

Length of stay in hospital

Patient satisfaction

CI: confidence interval; OR: odds ratio.

GRADE Working Group grades of evidence
High quality: We are very confident that the true effect lies close to that of the estimate of the effect.
Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect,
Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.