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Temas

Comparison 1 Minor acute wounds, Outcome 1 Time to healing.
Figuras y tablas -
Analysis 1.1

Comparison 1 Minor acute wounds, Outcome 1 Time to healing.

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Comparison 2 Partial thickness burns ‐ honey vs conventional dressings, Outcome 1 Time to healing (days).
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Analysis 2.1

Comparison 2 Partial thickness burns ‐ honey vs conventional dressings, Outcome 1 Time to healing (days).

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Comparison 3 Burns ‐ honey vs early excision, Outcome 1 Early excision.
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Analysis 3.1

Comparison 3 Burns ‐ honey vs early excision, Outcome 1 Early excision.

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Comparison 4 Burns ‐ honey vs silver sulfadiazine, Outcome 1 Time to healing (days).
Figuras y tablas -
Analysis 4.1

Comparison 4 Burns ‐ honey vs silver sulfadiazine, Outcome 1 Time to healing (days).

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Comparison 5 Burns ‐ honey vs unconventional dressings, Outcome 1 Time to healing (days).
Figuras y tablas -
Analysis 5.1

Comparison 5 Burns ‐ honey vs unconventional dressings, Outcome 1 Time to healing (days).

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Comparison 6 Mixed acute and chronic wounds, Outcome 1 Time to healing (days).
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Analysis 6.1

Comparison 6 Mixed acute and chronic wounds, Outcome 1 Time to healing (days).

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Comparison 7 Venous leg ulcers, Outcome 1 Complete healing.
Figuras y tablas -
Analysis 7.1

Comparison 7 Venous leg ulcers, Outcome 1 Complete healing.

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Comparison 8 Chronic wounds, Outcome 1 Time to healing (days).
Figuras y tablas -
Analysis 8.1

Comparison 8 Chronic wounds, Outcome 1 Time to healing (days).

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Comparison 9 Adverse events, Outcome 1 All adverse events.
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Analysis 9.1

Comparison 9 Adverse events, Outcome 1 All adverse events.

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Comparison 10 Incidence of infection, Outcome 1 Incidence of clinically diagnosed infection.
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Analysis 10.1

Comparison 10 Incidence of infection, Outcome 1 Incidence of clinically diagnosed infection.

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Comparison 10 Incidence of infection, Outcome 2 Burns patients with positive swab cultures at admission rendered sterile after 7 days treatment.
Figuras y tablas -
Analysis 10.2

Comparison 10 Incidence of infection, Outcome 2 Burns patients with positive swab cultures at admission rendered sterile after 7 days treatment.

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Table 1. Quality characteristics of trial report

Study

Randomisation

Allocation concealed

Loss reported

Intention to t

Blinded assessment

Groups comparable

Power calculation

Al Waili

Not reported, but described as RCT

Not reported

Yes (0%)

Not reported

Not reported

Yes

Not reported

Gethin

Yes

Yes

Yes

Yes

No

Yes

Yes

Ingle

Yes

Not reported

Yes (6%)

No

Yes

Yes

Yes

Jull

Yes

Yes

Yes (2%)

Yes

No

Yes

Yes

Marshall

Yes

Yes

Yes (14%)

No

Yes

No

Not reported

McIntosh

Yes

Yes

Yes (0%)

No

Yes

Yes

Yes

Mphande

No; allocation on alternating basis at admission

Inadequate

Yes (0%)

Not reported

Not reported

Yes

Not reported

Subrahmanyam 1991

Yes*

Unclear

Yes (0%)

Not reported

Yes*

Yes

Not reported

Subrahmanyam 1993a

Yes*

Unclear

Yes (0%)

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 1993a

Yes*

Unclear

Yes (0%)

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 1994

Yes*

Unclear

Yes (0%)

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 1996a

Yes*

Unclear

Not reported

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 1996b

Yes*

Unclear

Not reported

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 1996c

Yes*

Unclear

Yes (0%)

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 1998

Yes*

Unclear

Yes (0%)

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 1999

Yes*

Unclear

Yes (8%)

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 2001a

Yes*

Unclear

Yes (0%)

Not reported

Yes*

Yes*

Not reported

Subrahmanyam 2004

Yes*

Unclear

Not reported

Not reported

Yes

Yes*

Not reported

Weheida

Not reported, but described as RCT

Not reported

Yes (0%)

Not reported

Not reported

No

Not reported

* information provided by author
Figuras y tablas -
Table 1. Quality characteristics of trial report
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Table 2. Frequency of adverse events reported in burns trials (Subrahmanyam 1991, 1993a, 1994, 1996a, 1999, 2001a)

Adverse event

Honey

Control treatment

RR (95%CI)

Hypergranulation

8/548

17/548

0.47 (0.26 to 0.84)

Contracture

8/213

14/197

0.53 (0.30 to 0.93)

Minor scarring

28/450

87/450

0.32 (0.23 to 0.45)

Hypertrophic scarring

0/52

7/52

Not estimable
Figuras y tablas -
Table 2. Frequency of adverse events reported in burns trials (Subrahmanyam 1991, 1993a, 1994, 1996a, 1999, 2001a)
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Table 3. Frequency of adverse events reported in venous ulcer trial (Jull et al 2008)

Adverse event

Honey treatment

Control treatment

RR (95%CI)

Ulcer pain

47/187

18/181

2.53 (1.53 to 4.18)

Bleeding

3/187

3/181

0.97 (0.20 to 4.73)

Dermatitis

8/187

8/181

0.97 (0.37 to 2.52)

Deterioration of ulcer

19/187

9/181

2.04 (0.95 to 4.40)

Erythema

6/187

4/181

1.45 (0.42 to 5.06)

Oedema

4/187

1/181

3.87 (0.44 to 34.31)

Increased exudate

5/187

1/181

4.84 (0.57 to 41.02)

Deterioration of surrounding skin

5/187

3/181

1.61 (0.39 to 6.65)

New ulceration

16/187

15/181

1.03 (0.53 to 2.03)

Other

6/187

3/181

1.94 ( 0.49 to 7.62)

Cardiovascular

4/187

3/181

1.29 (0.29 to 5.69)

Cancer

2/187

2/181

0.97 (0.14 to 6.80)

Neurological

4/187

1/181

3.87 (0.44 to 34.31)

Gastrointestinal

4/187

2/181

1.94 (0.36 to 10.44)

Injury

10/187

9/181

1.08 (0.45 to 2.59)

Musculoskeletal

13/187

9/181

1.40 (0.61 to 3.19)

Respiratory

6/187

3/181

1.94 (0.49 to 7.62)

Other

3/187

8/181

0.41 (0.11 to 1.58)
Figuras y tablas -
Table 3. Frequency of adverse events reported in venous ulcer trial (Jull et al 2008)
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Comparison 1. Minor acute wounds

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Time to healing Show forest plot

3

213

Mean Difference (IV, Fixed, 95% CI)

1.55 [‐1.91, 5.00]
Figuras y tablas -
Comparison 1. Minor acute wounds
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Comparison 2. Partial thickness burns ‐ honey vs conventional dressings

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Time to healing (days) Show forest plot

2

992

Mean Difference (IV, Fixed, 95% CI)

‐4.68 [‐5.09, ‐4.28]
Figuras y tablas -
Comparison 2. Partial thickness burns ‐ honey vs conventional dressings
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Comparison 3. Burns ‐ honey vs early excision

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Early excision Show forest plot

1

50

Mean Difference (IV, Fixed, 95% CI)

13.60 [10.02, 17.18]
Figuras y tablas -
Comparison 3. Burns ‐ honey vs early excision
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Comparison 4. Burns ‐ honey vs silver sulfadiazine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Time to healing (days) Show forest plot

3

254

Mean Difference (IV, Random, 95% CI)

‐4.37 [‐8.94, 0.19]
Figuras y tablas -
Comparison 4. Burns ‐ honey vs silver sulfadiazine
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Comparison 5. Burns ‐ honey vs unconventional dressings

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Time to healing (days) Show forest plot

3

Mean Difference (IV, Random, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 5. Burns ‐ honey vs unconventional dressings
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Comparison 6. Mixed acute and chronic wounds

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Time to healing (days) Show forest plot

1

100

Mean Difference (IV, Fixed, 95% CI)

‐13.0 [‐15.24, ‐10.76]
Figuras y tablas -
Comparison 6. Mixed acute and chronic wounds
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Comparison 7. Venous leg ulcers

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Complete healing Show forest plot

2

476

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.96, 1.38]
Figuras y tablas -
Comparison 7. Venous leg ulcers
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Comparison 8. Chronic wounds

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Time to healing (days) Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Infected postoperative wounds

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 Pressure ulcers

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.3 Fournier's gangrene

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 8. Chronic wounds
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Comparison 9. Adverse events

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 All adverse events Show forest plot

11

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only

1.1 Minor acute wounds

1

82

Risk Ratio (M‐H, Random, 95% CI)

1.37 [0.77, 2.45]

1.2 Burns

6

1310

Risk Ratio (M‐H, Random, 95% CI)

0.85 [0.29, 2.51]

1.3 Infected post‐operative wounds

1

50

Risk Ratio (M‐H, Random, 95% CI)

0.31 [0.11, 0.82]

1.4 Venous leg ulcers

2

476

Risk Ratio (M‐H, Random, 95% CI)

1.27 [1.05, 1.55]

1.5 Fournier's gangrene

1

30

Risk Ratio (M‐H, Random, 95% CI)

0.57 [0.06, 5.65]
Figuras y tablas -
Comparison 9. Adverse events
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Comparison 10. Incidence of infection

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of clinically diagnosed infection Show forest plot

4

627

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.50, 1.04]

2 Burns patients with positive swab cultures at admission rendered sterile after 7 days treatment Show forest plot

6

444

Risk Ratio (M‐H, Random, 95% CI)

3.95 [1.36, 11.44]
Figuras y tablas -
Comparison 10. Incidence of infection
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