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Temas

Study flow‐diagram.
Figuras y tablas -
Figure 1

Study flow‐diagram.

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Comparison 1 Acarbose versus placebo, Outcome 1 Incidence of type 2 diabetes mellitus.
Figuras y tablas -
Analysis 1.1

Comparison 1 Acarbose versus placebo, Outcome 1 Incidence of type 2 diabetes mellitus.

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Comparison 1 Acarbose versus placebo, Outcome 2 Occurrence of death (total).
Figuras y tablas -
Analysis 1.2

Comparison 1 Acarbose versus placebo, Outcome 2 Occurrence of death (total).

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Comparison 1 Acarbose versus placebo, Outcome 3 Occurrence of cardiovascular death.
Figuras y tablas -
Analysis 1.3

Comparison 1 Acarbose versus placebo, Outcome 3 Occurrence of cardiovascular death.

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Comparison 1 Acarbose versus placebo, Outcome 4 Occurrence of cardiovascular disease (any).
Figuras y tablas -
Analysis 1.4

Comparison 1 Acarbose versus placebo, Outcome 4 Occurrence of cardiovascular disease (any).

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Comparison 1 Acarbose versus placebo, Outcome 5 Occurrence of myocardial infarctions.
Figuras y tablas -
Analysis 1.5

Comparison 1 Acarbose versus placebo, Outcome 5 Occurrence of myocardial infarctions.

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Comparison 1 Acarbose versus placebo, Outcome 6 Occurrence of angina pectoris.
Figuras y tablas -
Analysis 1.6

Comparison 1 Acarbose versus placebo, Outcome 6 Occurrence of angina pectoris.

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Comparison 1 Acarbose versus placebo, Outcome 7 Occurrence of revascularisation procedures.
Figuras y tablas -
Analysis 1.7

Comparison 1 Acarbose versus placebo, Outcome 7 Occurrence of revascularisation procedures.

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Comparison 1 Acarbose versus placebo, Outcome 8 Occurrence of congestive heart failure.
Figuras y tablas -
Analysis 1.8

Comparison 1 Acarbose versus placebo, Outcome 8 Occurrence of congestive heart failure.

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Comparison 1 Acarbose versus placebo, Outcome 9 Occurrence of cerebrovascular events.
Figuras y tablas -
Analysis 1.9

Comparison 1 Acarbose versus placebo, Outcome 9 Occurrence of cerebrovascular events.

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Comparison 1 Acarbose versus placebo, Outcome 10 Occurrence of peripheral vascular events.
Figuras y tablas -
Analysis 1.10

Comparison 1 Acarbose versus placebo, Outcome 10 Occurrence of peripheral vascular events.

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Comparison 1 Acarbose versus placebo, Outcome 11 Change in glycated haemoglobin (%).
Figuras y tablas -
Analysis 1.11

Comparison 1 Acarbose versus placebo, Outcome 11 Change in glycated haemoglobin (%).

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Comparison 1 Acarbose versus placebo, Outcome 12 Change in fasting blood glucose (mmol/l).
Figuras y tablas -
Analysis 1.12

Comparison 1 Acarbose versus placebo, Outcome 12 Change in fasting blood glucose (mmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 13 Change in post‐load blood glucose (mmol/l).
Figuras y tablas -
Analysis 1.13

Comparison 1 Acarbose versus placebo, Outcome 13 Change in post‐load blood glucose (mmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 14 Change in total cholesterol (mmol/l).
Figuras y tablas -
Analysis 1.14

Comparison 1 Acarbose versus placebo, Outcome 14 Change in total cholesterol (mmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 15 Change in HDL‐cholesterol (mmol/l).
Figuras y tablas -
Analysis 1.15

Comparison 1 Acarbose versus placebo, Outcome 15 Change in HDL‐cholesterol (mmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 16 Change in LDL‐cholesterol (mmol/l).
Figuras y tablas -
Analysis 1.16

Comparison 1 Acarbose versus placebo, Outcome 16 Change in LDL‐cholesterol (mmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 17 Change in triglycerides (mmol/l).
Figuras y tablas -
Analysis 1.17

Comparison 1 Acarbose versus placebo, Outcome 17 Change in triglycerides (mmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 18 Change in fasting insulin levels (pmol/l).
Figuras y tablas -
Analysis 1.18

Comparison 1 Acarbose versus placebo, Outcome 18 Change in fasting insulin levels (pmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 19 Change in post‐load insulin levels (pmol/l).
Figuras y tablas -
Analysis 1.19

Comparison 1 Acarbose versus placebo, Outcome 19 Change in post‐load insulin levels (pmol/l).

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Comparison 1 Acarbose versus placebo, Outcome 20 Change in body weight (Kg).
Figuras y tablas -
Analysis 1.20

Comparison 1 Acarbose versus placebo, Outcome 20 Change in body weight (Kg).

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Comparison 1 Acarbose versus placebo, Outcome 21 Change in body mass index (Kg/m2).
Figuras y tablas -
Analysis 1.21

Comparison 1 Acarbose versus placebo, Outcome 21 Change in body mass index (Kg/m2).

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Comparison 1 Acarbose versus placebo, Outcome 22 Change in diastolic blood pressure (mmHg).
Figuras y tablas -
Analysis 1.22

Comparison 1 Acarbose versus placebo, Outcome 22 Change in diastolic blood pressure (mmHg).

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Comparison 1 Acarbose versus placebo, Outcome 23 Change in systolic blood pressure (mmHg).
Figuras y tablas -
Analysis 1.23

Comparison 1 Acarbose versus placebo, Outcome 23 Change in systolic blood pressure (mmHg).

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Comparison 1 Acarbose versus placebo, Outcome 24 Occurrence of side effects (total).
Figuras y tablas -
Analysis 1.24

Comparison 1 Acarbose versus placebo, Outcome 24 Occurrence of side effects (total).

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Comparison 1 Acarbose versus placebo, Outcome 25 Occurrence of gastro‐intestinal side‐effects.
Figuras y tablas -
Analysis 1.25

Comparison 1 Acarbose versus placebo, Outcome 25 Occurrence of gastro‐intestinal side‐effects.

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Comparison 2 Acarbose versus metformin, Outcome 1 Incidence of type 2 diabetes mellitus.
Figuras y tablas -
Analysis 2.1

Comparison 2 Acarbose versus metformin, Outcome 1 Incidence of type 2 diabetes mellitus.

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Comparison 2 Acarbose versus metformin, Outcome 2 Change in fasting blood glucose (mmol/l).
Figuras y tablas -
Analysis 2.2

Comparison 2 Acarbose versus metformin, Outcome 2 Change in fasting blood glucose (mmol/l).

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Comparison 2 Acarbose versus metformin, Outcome 3 Change in post‐load blood glucose (mmol/l).
Figuras y tablas -
Analysis 2.3

Comparison 2 Acarbose versus metformin, Outcome 3 Change in post‐load blood glucose (mmol/l).

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Comparison 2 Acarbose versus metformin, Outcome 4 Change in total cholesterol (mmol/l).
Figuras y tablas -
Analysis 2.4

Comparison 2 Acarbose versus metformin, Outcome 4 Change in total cholesterol (mmol/l).

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Comparison 2 Acarbose versus metformin, Outcome 5 Change in triglycerides (mmol/l).
Figuras y tablas -
Analysis 2.5

Comparison 2 Acarbose versus metformin, Outcome 5 Change in triglycerides (mmol/l).

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Comparison 2 Acarbose versus metformin, Outcome 6 Change in body mass index (Kg/m2).
Figuras y tablas -
Analysis 2.6

Comparison 2 Acarbose versus metformin, Outcome 6 Change in body mass index (Kg/m2).

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Comparison 2 Acarbose versus metformin, Outcome 7 Change in diastolic blood pressure (mmHg).
Figuras y tablas -
Analysis 2.7

Comparison 2 Acarbose versus metformin, Outcome 7 Change in diastolic blood pressure (mmHg).

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Comparison 2 Acarbose versus metformin, Outcome 8 Change in systolic blood pressure (mmHg).
Figuras y tablas -
Analysis 2.8

Comparison 2 Acarbose versus metformin, Outcome 8 Change in systolic blood pressure (mmHg).

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Comparison 3 Acarbose versus diet and exercise, Outcome 1 Incidence of type 2 diabetes mellitus.
Figuras y tablas -
Analysis 3.1

Comparison 3 Acarbose versus diet and exercise, Outcome 1 Incidence of type 2 diabetes mellitus.

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Comparison 3 Acarbose versus diet and exercise, Outcome 2 Change in fasting blood glucose (mmol/l).
Figuras y tablas -
Analysis 3.2

Comparison 3 Acarbose versus diet and exercise, Outcome 2 Change in fasting blood glucose (mmol/l).

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Comparison 3 Acarbose versus diet and exercise, Outcome 3 Change in post‐load blood glucose (mmol/l).
Figuras y tablas -
Analysis 3.3

Comparison 3 Acarbose versus diet and exercise, Outcome 3 Change in post‐load blood glucose (mmol/l).

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Comparison 3 Acarbose versus diet and exercise, Outcome 4 Change in total cholesterol (mmol/l).
Figuras y tablas -
Analysis 3.4

Comparison 3 Acarbose versus diet and exercise, Outcome 4 Change in total cholesterol (mmol/l).

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Comparison 3 Acarbose versus diet and exercise, Outcome 5 Change in triglycerides (mmol/l).
Figuras y tablas -
Analysis 3.5

Comparison 3 Acarbose versus diet and exercise, Outcome 5 Change in triglycerides (mmol/l).

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Comparison 3 Acarbose versus diet and exercise, Outcome 6 Change in body mass index (Kg/m2).
Figuras y tablas -
Analysis 3.6

Comparison 3 Acarbose versus diet and exercise, Outcome 6 Change in body mass index (Kg/m2).

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Comparison 3 Acarbose versus diet and exercise, Outcome 7 Change in diastolic blood pressure (mmHg).
Figuras y tablas -
Analysis 3.7

Comparison 3 Acarbose versus diet and exercise, Outcome 7 Change in diastolic blood pressure (mmHg).

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Comparison 3 Acarbose versus diet and exercise, Outcome 8 Change in systolic blood pressure (mmHg).
Figuras y tablas -
Analysis 3.8

Comparison 3 Acarbose versus diet and exercise, Outcome 8 Change in systolic blood pressure (mmHg).

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Comparison 4 Acarbose versus no treatment, Outcome 1 Incidence of type 2 diabetes mellitus.
Figuras y tablas -
Analysis 4.1

Comparison 4 Acarbose versus no treatment, Outcome 1 Incidence of type 2 diabetes mellitus.

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Comparison 4 Acarbose versus no treatment, Outcome 2 Change in fasting blood glucose (mmol/l).
Figuras y tablas -
Analysis 4.2

Comparison 4 Acarbose versus no treatment, Outcome 2 Change in fasting blood glucose (mmol/l).

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Comparison 4 Acarbose versus no treatment, Outcome 3 Change in post‐load blood glucose (mmol/l).
Figuras y tablas -
Analysis 4.3

Comparison 4 Acarbose versus no treatment, Outcome 3 Change in post‐load blood glucose (mmol/l).

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Comparison 4 Acarbose versus no treatment, Outcome 4 Change in total cholesterol (mmol/l).
Figuras y tablas -
Analysis 4.4

Comparison 4 Acarbose versus no treatment, Outcome 4 Change in total cholesterol (mmol/l).

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Comparison 4 Acarbose versus no treatment, Outcome 5 Change in triglycerides (mmol/l).
Figuras y tablas -
Analysis 4.5

Comparison 4 Acarbose versus no treatment, Outcome 5 Change in triglycerides (mmol/l).

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Comparison 4 Acarbose versus no treatment, Outcome 6 Change in body mass index (Kg/m2).
Figuras y tablas -
Analysis 4.6

Comparison 4 Acarbose versus no treatment, Outcome 6 Change in body mass index (Kg/m2).

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Comparison 4 Acarbose versus no treatment, Outcome 7 Change in diastolic blood pressure (mmHg).
Figuras y tablas -
Analysis 4.7

Comparison 4 Acarbose versus no treatment, Outcome 7 Change in diastolic blood pressure (mmHg).

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Comparison 4 Acarbose versus no treatment, Outcome 8 Change in systolic blood pressure (mmHg).
Figuras y tablas -
Analysis 4.8

Comparison 4 Acarbose versus no treatment, Outcome 8 Change in systolic blood pressure (mmHg).

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Comparison 4 Acarbose versus no treatment, Outcome 9 Occurrence of side effects (total).
Figuras y tablas -
Analysis 4.9

Comparison 4 Acarbose versus no treatment, Outcome 9 Occurrence of side effects (total).

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Comparison 4 Acarbose versus no treatment, Outcome 10 Occurrence of gastro‐intestinal side‐effects.
Figuras y tablas -
Analysis 4.10

Comparison 4 Acarbose versus no treatment, Outcome 10 Occurrence of gastro‐intestinal side‐effects.

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Table 1. Risk of bias

Study

Randomisation

Allocation Conceal.

Treatment Blinding

ITT analysis

Quantity drop‐out

Selective drop‐out

Blind outcome‐assess

Analyses Blinding

Overall Quality

A = Adequate; B = Not adequate / unclear

A = Adequate; B = Not adequate / unclear

A = adequate, B = mentioning of blinding but exact method unclear, C = non‐blinded, inadequate or unknown

A = adequate, B = ITT inadequate, C = Unclear or no reported data on drop‐out / loss‐to‐follow‐up

A < 15%, B >= 15% or unknown

A = difference in drop‐out rate in main groups < 10%, B >= 10% or unknown

A = adequate, B = mentioning of blinding but exact method unclear, C = non‐blinded, inadequate or unknown

A = adequate, B = mentioning of blinding but exact method unclear, C = non‐blinded, inadequate or unknown

A = all quality criteria met; B = one or more quality criteria only partially met; C = one or more quality criteria not met

DAISI

B

B

B

C

B

A

B

B

C

EDIT

B

B

B

C

B

B

B

B

C

Fang 2004

A

B

C

B

A

A

B

B

C

STOP‐NIDDM

A

A

A

B

A

A

A

B

A

Wang 2000

B

B

C

B

A

A

B

B

C
Figuras y tablas -
Table 1. Risk of bias
Ir a la tabla de la revisión
Comparison 1. Acarbose versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of type 2 diabetes mellitus Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

1.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Occurrence of death (total) Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

2.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

3 Occurrence of cardiovascular death Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

3.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

4 Occurrence of cardiovascular disease (any) Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

4.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5 Occurrence of myocardial infarctions Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

5.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6 Occurrence of angina pectoris Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

6.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

7 Occurrence of revascularisation procedures Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

7.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

8 Occurrence of congestive heart failure Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

8.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9 Occurrence of cerebrovascular events Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

9.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10 Occurrence of peripheral vascular events Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

10.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11 Change in glycated haemoglobin (%) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

11.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

12 Change in fasting blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

12.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

13 Change in post‐load blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

13.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

14 Change in total cholesterol (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

14.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

15 Change in HDL‐cholesterol (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

15.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

16 Change in LDL‐cholesterol (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

16.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

17 Change in triglycerides (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

17.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

18 Change in fasting insulin levels (pmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

18.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

19 Change in post‐load insulin levels (pmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

19.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

20 Change in body weight (Kg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

20.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

21 Change in body mass index (Kg/m2) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

21.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

22 Change in diastolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

22.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

23 Change in systolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

23.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

24 Occurrence of side effects (total) Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

24.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

25 Occurrence of gastro‐intestinal side‐effects Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

25.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Acarbose versus placebo
Ir a la tabla de la revisión
Comparison 2. Acarbose versus metformin

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of type 2 diabetes mellitus Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

1.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Change in fasting blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

2.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 Change in post‐load blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

3.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4 Change in total cholesterol (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

4.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Change in triglycerides (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

5.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6 Change in body mass index (Kg/m2) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

6.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Change in diastolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

7.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8 Change in systolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

8.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 2. Acarbose versus metformin
Ir a la tabla de la revisión
Comparison 3. Acarbose versus diet and exercise

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of type 2 diabetes mellitus Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

1.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Change in fasting blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

2.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 Change in post‐load blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

3.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4 Change in total cholesterol (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

4.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Change in triglycerides (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

5.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6 Change in body mass index (Kg/m2) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

6.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Change in diastolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

7.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8 Change in systolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

8.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 3. Acarbose versus diet and exercise
Ir a la tabla de la revisión
Comparison 4. Acarbose versus no treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Incidence of type 2 diabetes mellitus Show forest plot

2

140

Odds Ratio (M‐H, Random, 95% CI)

0.22 [0.08, 0.59]

1.1 Acarbose 100 mg TID

2

140

Odds Ratio (M‐H, Random, 95% CI)

0.22 [0.08, 0.59]

2 Change in fasting blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

2.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 Change in post‐load blood glucose (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

3.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4 Change in total cholesterol (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

4.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Change in triglycerides (mmol/l) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

5.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6 Change in body mass index (Kg/m2) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

6.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Change in diastolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

7.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8 Change in systolic blood pressure (mmHg) Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

8.1 Acarbose 100 mg TID

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

9 Occurrence of side effects (total) Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

9.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10 Occurrence of gastro‐intestinal side‐effects Show forest plot

1

Odds Ratio (M‐H, Random, 95% CI)

Totals not selected

10.1 Acarbose 100 mg TID

1

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 4. Acarbose versus no treatment
Ir a la tabla de la revisión