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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 1 Mortality prior to discharge.
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Analysis 1.1

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 1 Mortality prior to discharge.

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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 2 Pulmonary hypertensive crises.
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Analysis 1.2

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 2 Pulmonary hypertensive crises.

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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 3 Difference in MPAP change score (SE).
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Analysis 1.3

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 3 Difference in MPAP change score (SE).

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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 4 Difference in MAP change score (SE).
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Analysis 1.4

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 4 Difference in MAP change score (SE).

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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 5 Difference in HR change score (SE).
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Analysis 1.5

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 5 Difference in HR change score (SE).

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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 6 Difference in PaO2:FiO2 change score.
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Analysis 1.6

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 6 Difference in PaO2:FiO2 change score.

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Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 7 Maximum methaemoglobin level.
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Analysis 1.7

Comparison 1 Inhaled nitric oxide versus placebo or conventional management, Outcome 7 Maximum methaemoglobin level.

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Table 1. Individual number of entries for outcome, "Difference in MPAP change score (SE)"

Trial

iNO (N)

Control (N)

Russell 1998

5

8

Day 2000

17

20

Morris 2000

11

11
Figuras y tablas -
Table 1. Individual number of entries for outcome, "Difference in MPAP change score (SE)"
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Table 2. Individual number of entries for outcome,"Difference in MAP change score (SE)"

Trial

iNO (N)

Control (N)

Russell 1998

5

8

Day 2000

18

20

Morris 2000

11

11
Figuras y tablas -
Table 2. Individual number of entries for outcome,"Difference in MAP change score (SE)"
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Table 3. Individual number of entries for outcome, "Difference in HR change score (SE)"

Trial

iNO (N)

Control (N)

Russell 1998

5

8

Day 2000

12

17

Morris 2000

11

11
Figuras y tablas -
Table 3. Individual number of entries for outcome, "Difference in HR change score (SE)"
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Comparison 1. Inhaled nitric oxide versus placebo or conventional management

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality prior to discharge Show forest plot

2

162

Odds Ratio (M‐H, Fixed, 95% CI)

1.67 [0.38, 7.30]

2 Pulmonary hypertensive crises Show forest plot

1

38

Odds Ratio (M‐H, Fixed, 95% CI)

0.8 [0.15, 4.18]

3 Difference in MPAP change score (SE) Show forest plot

3

Change in MPAP (Random, 95% CI)

‐2.94 [‐9.28, 3.40]

3.1 Conventional Management

2

Change in MPAP (Random, 95% CI)

‐1.14 [‐8.87, 6.59]

3.2 Placebo

1

Change in MPAP (Random, 95% CI)

‐9.15 [‐20.70, 2.40]

4 Difference in MAP change score (SE) Show forest plot

3

Change in MAP (Fixed, 95% CI)

‐3.55 [‐11.86, 4.76]

4.1 Conventional Mangement

2

Change in MAP (Fixed, 95% CI)

‐1.94 [‐11.23, 7.35]

4.2 Placebo

1

Change in MAP (Fixed, 95% CI)

‐10.0 [‐28.60, 8.60]

5 Difference in HR change score (SE) Show forest plot

3

Change in HR (Fixed, 95% CI)

0.02 [‐8.13, 8.18]

5.1 Conventional Management

2

Change in HR (Fixed, 95% CI)

‐0.37 [‐8.85, 8.10]

5.2 Placebo

1

Change in HR (Fixed, 95% CI)

5.0 [‐24.99, 34.99]

6 Difference in PaO2:FiO2 change score Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

17.18 [‐28.21, 62.57]

7 Maximum methaemoglobin level Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

0.30 [0.24, 0.36]
Figuras y tablas -
Comparison 1. Inhaled nitric oxide versus placebo or conventional management
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