1 Head and neck cancer Show forest plot

9

710

Risk Ratio (M‐H, Random, 95% CI)

0.83 [0.70, 0.98]

1.1 12 or fewer fractions each group

5

412

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.74, 1.17]

1.2 12 or fewer fractions with HBOT, more than 12 with control

4

281

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.41, 1.08]

1.3 More than 12 fractions each group

1

17

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.13, 2.70]

2 Head and neck ‐ best case scenario Show forest plot

9

743

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.62, 0.85]

2.1 12 or fewer fractions each group

5

439

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.64, 1.02]

2.2 12 or fewer fractions with HBOT, more than 12 with control

4

287

Risk Ratio (M‐H, Random, 95% CI)

0.63 [0.43, 0.91]

2.3 More than 12 fractions each group

1

17

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.13, 2.70]

3 Head and neck ‐ worst case scenario Show forest plot

9

743

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.76, 1.15]

3.1 12 or fewer fractions each group

5

439

Risk Ratio (M‐H, Random, 95% CI)

1.10 [0.90, 1.36]

3.2 12 or fewer fractions with HBOT, more than 12 with control

4

287

Risk Ratio (M‐H, Random, 95% CI)

0.71 [0.45, 1.13]

3.3 More than 12 fractions each group

1

17

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.13, 2.70]

4 Uterine cervix cancer Show forest plot

4

728

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.69, 1.11]

4.1 12 or fewer fractions each groups

3

329

Risk Ratio (M‐H, Fixed, 95% CI)

0.98 [0.70, 1.38]

4.2 More than 12 fractions each group

3

399

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.57, 1.10]

5 Uterine cervix ‐ best case scenario Show forest plot

4

732

Risk Ratio (M‐H, Fixed, 95% CI)

0.87 [0.69, 1.10]

6 Uterine cervix ‐ worst case scenario Show forest plot

4

732

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.72, 1.15]

7 Urinary bladder cancer Show forest plot

4

330

Risk Ratio (M‐H, Fixed, 95% CI)

0.97 [0.74, 1.27]

7.1 12 or fewer fractions each group

1

16

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.03, 1.35]

7.2 12 or fewer fractions with HBOT, more than 12 with control

1

38

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.44, 1.51]

7.3 More than 12 fractions each group

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

1.43 [0.68, 3.00]

7.4 Mixed fractionation scheme

1

236

Risk Ratio (M‐H, Fixed, 95% CI)

1.02 [0.73, 1.44]

8 Urinary bladder ‐ best case scenario Show forest plot

4

337

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.71, 1.21]

9 Urinary bladder ‐ worst case scenario Show forest plot

4

337

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.78, 1.34]

10 Bronchial cancer Show forest plot

1

49

Risk Ratio (M‐H, Fixed, 95% CI)

1.09 [0.72, 1.64]

11 Rectal cancer Show forest plot

1

4

Risk Ratio (M‐H, Fixed, 95% CI)

1.67 [0.48, 5.76]

12 Oesphageal cancer Show forest plot

1

4

Risk Ratio (M‐H, Fixed, 95% CI)

0.6 [0.17, 2.07]

13 Gliobastoma Show forest plot

1

4

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1 Head and neck cancer Show forest plot

3

189

Risk Ratio (M‐H, Fixed, 95% CI)

0.97 [0.83, 1.12]

1.1 12 or fewer fractions in each group

1

48

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.76, 1.40]

1.2 12 or fewer fractions with HBOT, more than 12 with control

1

124

Risk Ratio (M‐H, Fixed, 95% CI)

0.93 [0.79, 1.09]

1.3 More than 12 fractions in both HBOT and control

1

17

Risk Ratio (M‐H, Fixed, 95% CI)

1.19 [0.37, 3.76]

2 Head and neck ‐ best case scenario Show forest plot

3

195

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.79, 1.07]

2.1 12 or fewer fractions in each group

1

48

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.76, 1.40]

2.2 12 or fewer fractions with HBOT, more than 12 with control

1

130

Risk Ratio (M‐H, Fixed, 95% CI)

0.87 [0.73, 1.03]

2.3 More than 12 fractions in both HBOT and control

1

17

Risk Ratio (M‐H, Fixed, 95% CI)

1.19 [0.37, 3.76]

3 Head and neck ‐ worst case scenario Show forest plot

3

195

Risk Ratio (M‐H, Fixed, 95% CI)

1.00 [0.86, 1.15]

3.1 12 or fewer fractions in each group

1

48

Risk Ratio (M‐H, Fixed, 95% CI)

1.03 [0.76, 1.40]

3.2 12 or fewer fractions with HBOT, more than 12 with control

1

130

Risk Ratio (M‐H, Fixed, 95% CI)

0.98 [0.83, 1.14]

3.3 More than 12 fractions in both HBOT and control

1

17

Risk Ratio (M‐H, Fixed, 95% CI)

1.19 [0.37, 3.76]

4 Uterine cervix cancer Show forest plot

4

607

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.76, 1.15]

4.1 12 or fewer fractions in HBOT and control

1

71

Risk Ratio (M‐H, Random, 95% CI)

0.72 [0.47, 1.09]

4.2 More than 12 fractions in HBOT and control

4

536

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.81, 1.21]

5 Urinary bladder carcinoma Show forest plot

2

24

Risk Ratio (M‐H, Fixed, 95% CI)

1.57 [0.63, 3.92]

6 Urinary bladder ‐ best case Show forest plot

2

58

Risk Ratio (M‐H, Random, 95% CI)

0.47 [0.04, 5.24]

7 Urinary bladder ‐ worst case Show forest plot

2

58

Risk Ratio (M‐H, Fixed, 95% CI)

5.18 [2.18, 12.31]

1 Head and neck cancer Show forest plot

6

550

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.69, 0.98]

1.1 12 or fewer fractions each group

3

349

Risk Ratio (M‐H, Fixed, 95% CI)

0.96 [0.75, 1.22]

1.2 12 or fewer fractions in HBOT, more than 12 in control

4

201

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.53, 0.89]

2 Head and neck ‐ best case scenario Show forest plot

6

575

Risk Ratio (M‐H, Fixed, 95% CI)

0.77 [0.64, 0.92]

2.1 12 or fewer fractions in each group

3

368

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.69, 1.12]

2.2 12 or fewer fractions in HBOT, more than 12 in control

4

207

Risk Ratio (M‐H, Fixed, 95% CI)

0.66 [0.51, 0.85]

3 Head and neck ‐ worst case scenario Show forest plot

6

575

Risk Ratio (M‐H, Fixed, 95% CI)

0.96 [0.81, 1.13]

3.1 12 or fewer fractions each group

3

368

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.92, 1.45]

3.2 12 or fewer fractions in HBOT, more than 12 in control

4

207

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.59, 0.96]

4 Uterine cervix cancer Show forest plot

4

772

Risk Ratio (M‐H, Random, 95% CI)

0.95 [0.80, 1.14]

4.1 12 or fewer fractions each group

3

329

Risk Ratio (M‐H, Random, 95% CI)

0.91 [0.62, 1.34]

4.2 More than 12 fractions in each group

2

385

Risk Ratio (M‐H, Random, 95% CI)

0.96 [0.81, 1.15]

4.3 12 or fewer fractions in HBOT versus more than 12 in control

1

58

Risk Ratio (M‐H, Random, 95% CI)

1.06 [0.70, 1.61]

5 Uterine cancer ‐ best case scenario Show forest plot

4

783

Risk Ratio (M‐H, Random, 95% CI)

0.92 [0.77, 1.09]

5.1 12 or fewer fractions in each group

3

333

Risk Ratio (M‐H, Random, 95% CI)

0.88 [0.61, 1.28]

5.2 More than 12 fractions in each group

2

385

Risk Ratio (M‐H, Random, 95% CI)

0.96 [0.81, 1.15]

5.3 12 or fewer fractions in HBOT versus more than 12 in control

1

65

Risk Ratio (M‐H, Random, 95% CI)

0.86 [0.57, 1.32]

6 Uterine cancer ‐ worst case scenario Show forest plot

4

783

Risk Ratio (M‐H, Random, 95% CI)

0.98 [0.81, 1.18]

6.1 12 or fewer fractions in each group

3

333

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.63, 1.38]

6.2 More than 12 fractions in each group

2

385

Risk Ratio (M‐H, Random, 95% CI)

0.96 [0.81, 1.15]

6.3 12 or fewer fractions in HBOT versus more than 12 in control

1

65

Risk Ratio (M‐H, Random, 95% CI)

1.18 [0.79, 1.77]

7 Urinary bladder cancer Show forest plot

1

236

Risk Ratio (M‐H, Fixed, 95% CI)

1.04 [0.88, 1.22]

1 Head and neck cancer Show forest plot

5

446

Risk Ratio (M‐H, Random, 95% CI)

0.58 [0.39, 0.85]

1.1 12 or fewer fractions each group

5

420

Risk Ratio (M‐H, Random, 95% CI)

0.54 [0.34, 0.88]

1.2 Less than 12 fractions in HBOT group versus more than 12 in control

1

26

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.24, 1.82]

2 Head and neck cancer ‐ best case scenario Show forest plot

5

465

Risk Ratio (M‐H, Random, 95% CI)

0.57 [0.41, 0.78]

2.1 12 or fewer fractions in each group

5

439

Risk Ratio (M‐H, Random, 95% CI)

0.53 [0.36, 0.80]

2.2 Less than 12 fractions in HBOT versus more than 12 in control

1

26

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.24, 1.82]

3 Head and neck ‐ worst case scenario Show forest plot

5

465

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.35, 1.00]

3.1 12 or fewer fractions in each group

5

439

Risk Ratio (M‐H, Random, 95% CI)

0.56 [0.30, 1.05]

3.2 Less than 12 fractions in HBOT versus more than 12 in control

1

26

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.24, 1.82]

1 Head and neck cancer Show forest plot

5

582

Risk Ratio (M‐H, Fixed, 95% CI)

0.66 [0.56, 0.78]

1.1 12 or fewer fractions each group

3

355

Risk Ratio (M‐H, Fixed, 95% CI)

0.62 [0.50, 0.77]

1.2 12 or fewer fractions with HBOT, more than 12 with control

2

227

Risk Ratio (M‐H, Fixed, 95% CI)

0.73 [0.57, 0.94]

2 Head and neck cancer ‐ best case scenario Show forest plot

5

611

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.51, 0.71]

2.1 12 or fewer fractions in each group

3

374

Risk Ratio (M‐H, Fixed, 95% CI)

0.56 [0.45, 0.70]

2.2 12 or fewer fractions with HBOT, more than 12 with control

2

237

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.53, 0.87]

3 Head and neck cancer ‐ worst case scenario Show forest plot

5

611

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.65, 0.87]

3.1 12 or fewer fractions in each group

3

374

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.60, 0.87]

3.2 12 or fewer fractions with HBOT, more than 12 with control

2

237

Risk Ratio (M‐H, Fixed, 95% CI)

0.81 [0.64, 1.03]

4 Uterine cervix cancer Show forest plot

3

714

Risk Ratio (M‐H, Random, 95% CI)

0.82 [0.63, 1.06]

4.1 12 or fewer fractions each group

3

329

Risk Ratio (M‐H, Random, 95% CI)

0.85 [0.57, 1.27]

4.2 more than 12 fractions in each group

2

385

Risk Ratio (M‐H, Random, 95% CI)

0.79 [0.49, 1.28]

5 Uterine cervix cancer ‐ best case scenario Show forest plot

3

718

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.63, 1.02]

5.1 12 or fewer fractions in each group

3

333

Risk Ratio (M‐H, Random, 95% CI)

0.82 [0.58, 1.17]

5.2 More than 12 fractions in each group

2

385

Risk Ratio (M‐H, Random, 95% CI)

0.79 [0.49, 1.28]

6 Uterine cervix cancer ‐ worst case scenario Show forest plot

3

718

Risk Ratio (M‐H, Random, 95% CI)

0.87 [0.63, 1.19]

6.1 12 or fewer fractions in each group

3

333

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.56, 1.58]

6.2 More than 12 fractions in each group

2

385

Risk Ratio (M‐H, Random, 95% CI)

0.79 [0.49, 1.28]

1 Head and neck cancer Show forest plot

1

48

Risk Ratio (M‐H, Fixed, 95% CI)

0.83 [0.60, 1.14]

2 Uterine cervix cancer Show forest plot

2

360

Risk Ratio (M‐H, Random, 95% CI)

0.60 [0.38, 0.97]

2.1 12 or fewer fractions in each group

1

71

Risk Ratio (M‐H, Random, 95% CI)

0.53 [0.37, 0.77]

2.2 More than 12 fractions in each group

2

289

Risk Ratio (M‐H, Random, 95% CI)

0.68 [0.26, 1.73]

1 Head and neck cancer Show forest plot

5

495

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.62, 0.95]

1.1 12 or fewer fractions in each group

2

324

Risk Ratio (M‐H, Random, 95% CI)

0.74 [0.62, 0.88]

1.2 12 or fewer fractions in HBOT, more than 12 in control

3

171

Risk Ratio (M‐H, Random, 95% CI)

0.75 [0.39, 1.43]

2 Head and neck cancer ‐ best case scenario Show forest plot

5

521

Risk Ratio (M‐H, Random, 95% CI)

0.70 [0.57, 0.86]

2.1 12 or fewer fractions in each group

2

343

Risk Ratio (M‐H, Random, 95% CI)

0.70 [0.52, 0.94]

2.2 12 or fewer fractions in HBOT, more than 12 in control

3

178

Risk Ratio (M‐H, Random, 95% CI)

0.70 [0.43, 1.12]

3 Head and neck cancer ‐ worst case scenario Show forest plot

5

521

Risk Ratio (M‐H, Random, 95% CI)

0.84 [0.66, 1.06]

3.1 12 or fewer fractions in each group

2

343

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.69, 0.95]

3.2 12 or fewer fractions in HBOT, more than 12 in control

3

178

Risk Ratio (M‐H, Random, 95% CI)

0.80 [0.38, 1.71]

4 Uterine cervix cancer Show forest plot

4

772

Risk Ratio (M‐H, Random, 95% CI)

0.85 [0.65, 1.13]

4.1 12 or fewer fractions each group

3

329

Risk Ratio (M‐H, Random, 95% CI)

0.83 [0.49, 1.41]

4.2 12 or fewer fractions in HBOT group versus more than 12 fractions in control

1

58

Risk Ratio (M‐H, Random, 95% CI)

1.25 [0.58, 2.71]

4.3 12 or more fractions in each group

2

385

Risk Ratio (M‐H, Random, 95% CI)

0.83 [0.52, 1.32]

5 Uterine cervix cancer ‐ best case scenario Show forest plot

4

783

Risk Ratio (M‐H, Fixed, 95% CI)

0.83 [0.72, 0.97]

5.1 12 or fewer fractions in each group

3

333

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.70, 1.05]

5.2 12 or fewer fractions in HBOT, more than 12 in controls

2

385

Risk Ratio (M‐H, Fixed, 95% CI)

0.80 [0.64, 1.01]

5.3 More than 12 fractions in each group

1

65

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.44, 1.89]

6 Uterine cervix cancer ‐ worst case scenario Show forest plot

4

783

Risk Ratio (M‐H, Fixed, 95% CI)

0.89 [0.76, 1.03]

6.1 12 or fewer fractions in each group

3

333

Risk Ratio (M‐H, Fixed, 95% CI)

0.90 [0.74, 1.10]

6.2 12 or fewer fracxtions in HBOT, more than 12 in controls

2

385

Risk Ratio (M‐H, Fixed, 95% CI)

0.80 [0.64, 1.01]

6.3 More than 12 fractions in each group

1

65

Risk Ratio (M‐H, Fixed, 95% CI)

1.60 [0.78, 3.28]

1 Uterine cervix cancer Show forest plot

1

320

Risk Ratio (M‐H, Fixed, 95% CI)

0.79 [0.52, 1.19]

1.1 10 or fewer fractions

1

71

Risk Ratio (M‐H, Fixed, 95% CI)

0.97 [0.35, 2.73]

1.2 11 or more fractions

1

249

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.48, 1.19]

1 Uterine cervix cancer Show forest plot

3

522

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.84, 1.31]

1.1 More than 12 fractions in each group

3

522

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.84, 1.31]

2 Urinary bladder carcinoma Show forest plot

2

80

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [0.58, 6.91]

3 Carcinoma of the bronchus Show forest plot

1

49

Risk Ratio (M‐H, Fixed, 95% CI)

1.04 [0.60, 1.80]

1 Head and neck carcinoma Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.46 [0.09, 2.30]

2 Uterine cervix cancer Show forest plot

3

456

Risk Ratio (M‐H, Random, 95% CI)

0.79 [0.50, 1.26]

2.1 12 or fewer fractions each group

2

149

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.45, 0.99]

2.2 12 or fewer fractions in HBOT group versus more than 12 fractions in control

1

58

Risk Ratio (M‐H, Random, 95% CI)

0.07 [0.00, 1.12]

2.3 More than 12 fractions in each group

1

249

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.78, 1.26]

3 Uterine cervix cancer ‐ best case scenario Show forest plot

3

467

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.46, 1.26]

3.1 12 or fewer fractions in each group

2

153

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.45, 0.98]

3.2 12 or fewer fractions in HBOT versus more than 12 in control

1

65

Risk Ratio (M‐H, Random, 95% CI)

0.05 [0.00, 0.79]

3.3 More than 12 fractions in each group

1

249

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.78, 1.26]

4 Uterine cervix cancer ‐ worst case scenario Show forest plot

3

467

Risk Ratio (M‐H, Random, 95% CI)

0.85 [0.56, 1.31]

4.1 12 or fewer fractions in each group

2

153

Risk Ratio (M‐H, Random, 95% CI)

0.96 [0.35, 2.68]

4.2 12 or fewer fractions in HBOT versus more than 12 in control

1

65

Risk Ratio (M‐H, Random, 95% CI)

0.39 [0.11, 1.38]

4.3 More than 12 fractions in each group

1

249

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.78, 1.26]

1 Death through radiation tissue injury Show forest plot

2

633

Risk Ratio (M‐H, Fixed, 95% CI)

1.64 [0.89, 3.03]

2 Severe radiation tissue injury Show forest plot

7

779

Risk Ratio (M‐H, Fixed, 95% CI)

2.35 [1.66, 3.33]

3 Severe radiation tissue injury ‐ best case scenario Show forest plot

7

803

Risk Ratio (M‐H, Fixed, 95% CI)

1.94 [1.39, 2.69]

4 Severe radiation tissue injury ‐ worst case scenario Show forest plot

7

803

Risk Ratio (M‐H, Fixed, 95% CI)

2.69 [1.92, 3.77]

5 Acute central nervous system oxygen toxicity Show forest plot

4

331

Risk Ratio (M‐H, Fixed, 95% CI)

6.76 [1.16, 39.31]

5.1 12 or fewer oxygen fractions

3

242

Risk Ratio (M‐H, Fixed, 95% CI)

4.30 [0.47, 39.60]

5.2 More than 12 oxygen fractions

1

89

Risk Ratio (M‐H, Fixed, 95% CI)

10.76 [0.61, 188.98]

6 Acute central nervous system toxicity ‐ best case scenario Show forest plot

4

337

Risk Ratio (M‐H, Fixed, 95% CI)

3.00 [0.81, 11.10]

6.1 12 or fewer oxygen fractions

3

248

Risk Ratio (M‐H, Fixed, 95% CI)

1.30 [0.26, 6.53]

6.2 More than 12 oxygen fractions

1

89

Risk Ratio (M‐H, Fixed, 95% CI)

10.76 [0.61, 188.98]

7 Acute central nervous system toxicity ‐ worst case scenario Show forest plot

4

337

Risk Ratio (M‐H, Fixed, 95% CI)

9.74 [1.73, 54.98]

7.1 12 or fewer oxygen fractions

3

248

Risk Ratio (M‐H, Fixed, 95% CI)

9.12 [1.05, 79.50]

7.2 More than 12 oxygen fractions

1

89

Risk Ratio (M‐H, Fixed, 95% CI)

10.76 [0.61, 188.98]

8 Middle ear barotrauma Show forest plot

1

89

Risk Ratio (M‐H, Fixed, 95% CI)

6.85 [0.36, 128.83]