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Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media

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Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

(1) To compare the effectiveness of amoxicillin with or without clavulanate between once or twice daily doses, with three or four times daily doses for the treatment of acute otitis media in children.
(2) To compare the complication rates between once or twice daily doses with three or four times daily doses.
(3) To compare the adverse reactions between the dosing intervals.